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NewLimit

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  • Scientific Talent Partner

    South San Francisco

    unspecified $95K-$105K

    Scientific Talent Partner South San Francisco Company info NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Description NewLimit is seeking a Scientific Talent Partner to work directly with our senior scientific leaders and Head of People to identify and engage top talent across our technical domains. This role offers an ideal transition opportunity for academics exploring industry careers. You'll gain exposure to diverse biotech functions while building industry connections and learning about career paths in an innovative and scientifically rigorous environment. As our Scientific Talent Partner, you will: - Lead campaigns to identify Top Talent for internal opportunities, leveraging your deep understanding of our technical domains to identify and attract candidates - Map talent landscapes based on publications, associations with leading labs and academic institutions, and relevant industry experience across epigenetic reprogramming, functional genomics, single cell sequencing, and computational biology - Partner closely with hiring managers to help them understand available talent pools and define optimal candidate profiles for their specific roles - Build and maintain relationships with top scientists, lab leaders, and academic institutions to create a robust talent pipeline - Represent NewLimit at scientific conferences and networking events to build our presence in the scientific community

  • Senior/Research Associate, Functional Genomics

    South San Francisco, CA

    unspecified $75K-$100K

    Senior/Research Associate, Functional Genomics South San Francisco, CA About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking a Senior/Research Associate with experience in molecular biology to join our Epigenetic Editing group. Pooled screening technologies are at the heart of our discovery engine, allowing us to rapidly search for epigenetic reprogramming therapies that restore cell function and reduce the burden of disease. As a member of our team, you will: - Collaborate with our Single Cell Technology team to implement large-scale, single cell perturbation experiments with custom chemistries - Build recombinant DNA vectors by synthesis and cloning to enable large-scale single cell perturbation experiments - Prepare, titer, and apply viral vectors (lentiviral, AAV) to transduce mammalian cell lines and primary cells - Contribute to scaling and improving pooled single cell perturbation screens Requirements - Bachelor's degree in cell biology, molecular biology, or a related natural science or industry experience - 2+ years of work experience in a cell or molecular biology laboratory (academic or industry) - Experience with molecular cloning, nucleic acid analysis (RT-qPCR, gel electrophoresis), and related molecular biology methods - Experience with mammalian cell culture Nice to have - Experience with next-generation

  • Head of Manufacturing

    South San Francisco

    unspecified Salary not disclosed

    Head of Manufacturing South San Francisco Company info NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat aging and age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and artificial intelligence systems to unravel the biology of aging and disease using experiments of unprecedented scale. Description NewLimit is recruiting a Head of Manufacturing to lead drug substance and product chemistry, manufacturing, and controls (CMC). We are creating a new class of epigenetic reprogramming medicines for aging that build upon LNP and mRNA technology. Our initial assets are progressing through the complex manufacturing cascade that these modalities entail. In this role, you will orchestrate manufacturing for some of the first reprogramming medicines to enter human trials. You will serve as the company's resident expert in manufacturing & controls, and manage a team of talented scientists & engineers to achieve your goals. As part of the role you will: - Lead manufacturing campaigns for epigenetic reprogramming medicines spanning DNA, mRNA, and lipid nanoparticle manufacturing - Own manufacturing timelines and deliverables for the world's first reprogramming medicines - Orchestrate contract manufacturing organizations, debug logistical issues, and keep timelines on track - Manage and recruit talented scientists and engineers in drug substance and drug product teams - Get in the lab and help teach, troubleshoot, and unblock projects Requirements - Ph.D. in a natural science or engineering discipline (biology, chemistry;

  • Scientist, Drug Product Analytical

    South San Francisco

    unspecified $130K-$170K

    Scientist, Drug Product Analytical South San Francisco About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position We are seeking a skilled and motivated Scientist to join our Delivery Sciences team. In this role, you will focus on building the analytical methods to characterize Lipid Nanoparticles (LNPs) to enable our nucleic acid delivery technologies and support the drug product development. Expertise in developing and implementing analytical methods to characterize RNA drug substances and LNP drug products, with experience managing method qualification, validation, and tech-transfer processes. What you'll do In your role as a Scientist, you will: - Design and execute analytical methods to assess the identity, integrity and purity of RNA drug substances and LNP drug products and LNP-conjugates - Perform deep-dive analysis into mRNA integrity, identity, lipid content and identity analysis to support drug product stability studies - Work closely with the cross-functional teams to support RNA and LNP analysis for drug development from early discovery to GLP/GMP stages. Act as a technical expert for our CRO/CDMO partners on drug substance and drug product analytical method development, validation phases and PK/PD assay developments - Interpret data from various analytical assays, reports and prepare data packages -

  • Senior Scientist, mRNA engineering

    South San Francisco

    unspecified $160K-$185K

    Senior Scientist, mRNA engineering South San Francisco About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking a Senior Scientist to drive our mRNA production and engineering efforts. This is a hands-on, lab based role focused on the synthesis, purification, and characterization of mRNA at large scales and high purities. You will serve as the technical lead for our production workflow, bridging the gap between molecular design and high quality material generation for in vivo and in vitro studies. What you'll do As a member of our team, you will: - Execute and scale end-to-end mRNA production, including template preparation, in vitro transcription (IVT), and purification (TFF, chromatography). - Implement rigorous quality control assays, including direct RNA sequencing, fragment analysis, dsRNA quantitation, and residual contaminant analysis. - Author and maintain detailed SOPs and batch records, ensuring all production runs meet GLP standards. - Independently design and execute experiments to improve mRNA sequence potency, specificity, and manufacturing performance. - Train, manage, and mentor other team members on mRNA optimization and production workflows. Requirements - PhD in molecular biology, biochemistry, cell biology, or a related field or equivalent industry experience (5+ years). - Deep hands-on experience

  • Scientist/Senior Scientist, PK/PD Assays

    South San Francisco

    unspecified $130K-$160K

    Scientist/Senior Scientist, PK/PD Assays South San Francisco About NewLimit NewLimit is seeking a Scientist or Senior Scientist with deep expertise in molecular biology, pharmacokinetics and translational biomarker assay development. In this role, you will lead the design, development, and qualification of pharmacokinetic (PK) and pharmacodynamic (PD) assays that characterize the biodistribution and biological activity of our mRNA-LNP medicines in preclinical and IND enabling studies. You will serve as a technical leader within our bioanalytical function, shaping biomarker assay strategy and partnering cross-functionally to advance our therapeutic programs toward IND-enabling milestones. What you'll do - Own the end-to-end design, development, and qualification of PK and PD biomarker assays across various platforms to support preclinical and IND-enabling studies - Discover and validate pharmacodynamic biomarkers to support the clinical development of drugs across multiple programs - Drive data analysis, interpretation, and reporting for bioanalytical studies to support program decision-making with audit-ready data packages - Contribute to sample processing workflows including tissue harvesting, primary cell culture, and complex matrix handling - Mentor research associates, establish SOPs, and build institutional knowledge within the bioanalytical function Requirements - PhD in molecular biology, biochemistry, cell biology, or a related field or equivalent industry experience (5+ years) - 3+ years of hands-on experience in various quantitative bioanalytical assay platforms (e.g., RT-qPCR, ddPCR, ELISA, MSD, Olink, SOMAscan, NGS-based methods) in complex biological matrices (serum, plasma, tissue homogenates) - Strong working knowledge of bioanalytical method qualification/validation principles for PK/PD biomarker measurements, including familiarity with ICH M10 guidelines and fit-for-purpose frameworks

  • VP, Clinical Development

    South San Francisco, CA

    unspecified Salary not disclosed

    VP, Clinical Development South San Francisco, CA Company info NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and artificial intelligence systems to unravel the biology of aging and disease using experiments of unprecedented scale. Description NewLimit is recruiting a VP of Clinical Development to plan and execute our first clinical trials. Our most advanced assets restore youthful hepatic metabolism and hold the potential to benefit diverse populations with liver disease and metabolic dysfunction. Our early stage programs have similar potential for impact in renal and inflammatory disease indications. In this role, you will design and orchestrate clinical trials for some of the world's first reprogramming medicines. You will serve as the company's senior clinical scientist and as a member of our executive team. As part of your role, you will: - Lead and orchestrate clinical development activities in collaboration with external partners. - Create clinical trial protocols, author and own regulatory submissions, and contribute to regulatory interactions. - Solve the inevitable logistical bottlenecks that block progress of our clinical studies. - Serve as a member of NewLimit's Executive Team and contribute to budgeting, goal setting, and technical review decisions. - Build and run a clinical development team as we approach first-in-human dosing. Requirements - M.D. or equivalent clinical training - Experience planning and orchestrating first-in-human trials

  • Computational Biologist

    South San Francisco, CA

    unspecified $150K-$200K

    Computational Biologist South San Francisco, CA About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Description NewLimit is seeking a Computational Biologist to join our Predict team. In this role, you will develop, improve, and operate bioinformatics pipelines supporting large-scale single-cell perturbation screens. Success in this position requires a deep attention to methodological detail at every stage of the analysis, as well as careful measurement and evaluation of pipeline performance. You will work closely with experimentalists and computational scientists to maintain core infrastructure, assess emerging analysis tools, and build robust software solutions that improve efficiency, scalability, and reliability. As a member of our team, you will: - Collaborate with Write, Read, and Predict teams to support the design, execution, and interpretation of experiments using single-cell and multi-omics data - Contribute to the development and implementation of primary and secondary analysis software. - Improve and run production pipelines for large-scale single-cell perturbation screens to ensure timely and reliable data delivery - Contribute to the development of reproducible, well-documented computational workflows and internal best practices - Develop microservice web applications and integrations that reduce wet lab manual effort and improve data flow between teams Requirements - Bachelor's, Master's, or

  • Senior/Research Associate

    South San Francisco

    unspecified $75K-$100K

    Senior/Research Associate South San Francisco About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking an Senior/Research Associate with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases. Your role will focus on supporting the development of in vitro assays and pre-clinical models to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our scientists as well as our technology-focused teams to help create the first reprogramming medicines for the vascular tissue. What you'll do In your role as a Senior/Research Associate, you will: - Isolate cells from primary tissues to optimize in vitro functional assays - Develop pre‑clinical models of age-related dysfunction - Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions at scale - Support the development of in vivo nucleic acid delivery methods for endothelial cells - Analyze and interpret experimental data to drive pre-clinical decision making Requirements - Bachelor's degree in cell biology, molecular biology, biochemistry or

  • Scientist/Senior Scientist, Immunology

    South San Francisco

    unspecified $130K-$180K

    Scientist/Senior Scientist, Immunology South San Francisco About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking a highly motivated Scientist/Senior Scientist in Immunology to lead and execute key discovery-to-preclinical research efforts in inflammatory and autoimmune diseases, with a strong emphasis on T cell and regulatory T cell (Treg) biology. This role will design and implement in vitro screening assays to support lead selection and contribute to preclinical efficacy, safety, and mechanism-of-action studies. You will work closely with cross-functional partners to support program advancement toward IND-enabling studies. What you'll do In your role as a Scientist, you will: - Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and evaluate epigenetic reprogramming interventions for aged T cells, including integration and interpretation of complex, multi-modal datasets - Develop scalable functional assays in T cells and Tregs to predict therapeutic activity and inform lead selection - Design and lead in vivo and in vitro immunology studies to support target discovery, validation, and preclinical development - Contribute deep expertise in inflammatory and autoimmune disease biology to experimental design and data-driven program strategy - Drive research in Treg biology, including differentiation, stability, and suppressive

  • Senior Research Associate, Metabolism

    South San Francisco

    unspecified $90K-$105K

    Senior Research Associate, Metabolism South San Francisco About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking a Senior Research Associate with experience in liver biology or in vivo physiology to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will help develop epigenetic editing tools, functional assays, and model systems to measure the effectiveness of our therapeutic candidates. What you'll do - Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes - Perform experiments in preclinical animal models of liver disease - Conduct functional and phenotypic assays to evaluate the effects of reprogramming on hepatocyte biology in vivo - Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles) - Isolate murine and human hepatocytes by liver perfusion with downstream FACS analysis Requirements - BS in cell biology, molecular biology, or a related natural science and 2+ years of work experience in a cell biology or animal physiology laboratory (academic

  • Scientist/Senior Scientist

    South San Francisco, CA

    unspecified $130K-$180K

    Scientist/Senior Scientist South San Francisco, CA About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking an scientist with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases. Your role will focus on developing and deploying assays to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our technology teams to help create the first reprogramming medicines for the vascular tissue that supports all others. What you'll do In your role as a Scientist, you will: - Develop functional assays and pre-clinical models to measure endothelial cell function - Collaborate with our Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale - Measure the impact of mRNA reprogramming medicines on endothelial cell function - Engineer in vivo nucleic acid delivery methods for endothelial cells - Analyze and interpret experimental data to drive pre-clinical decision making Requirements - Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years) - Experience with primary cell