Senior Research Associate, Metabolism

Benefits

Parental leave

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Non-birth-parent leave

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Family-building benefits

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• Surrogacy assistance: Not verified

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Market context

Median wage (BLS OEWS)

$111,944 national median

Projected growth (BLS Employment Projections)

+13.7% - Much faster than average

13% below the BLS national median for data and ml aggregate.

Matched to SOC 15-1252 - Data and ML aggregate by role bucket.

Source: U.S. Bureau of Labor Statistics, OEWS, May 2024 and Employment Projections, 2024-2034.

Schedule

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Weekend work

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Application

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Deadline

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About this role

Senior Research Associate, Metabolism South San Francisco About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking a Senior Research Associate with experience in liver biology or in vivo physiology to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will help develop epigenetic editing tools, functional assays, and model systems to measure the effectiveness of our therapeutic candidates. What you'll do - Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes - Perform experiments in preclinical animal models of liver disease - Conduct functional and phenotypic assays to evaluate the effects of reprogramming on hepatocyte biology in vivo - Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles) - Isolate murine and human hepatocytes by liver perfusion with downstream FACS analysis Requirements - BS in cell biology, molecular biology, or a related natural science and 2+ years of work experience in a cell biology or animal physiology laboratory (academic

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