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Personalis INC

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  • Sr. Staff Scientist, Assay R&D

    Fremont, CA

    unspecified $170K-$200K

    Sr. Staff Scientist, Assay R&D Fremont, CA Based in Fremont, California, Personalis is a genome-oriented diagnostics company pioneering new paradigms in cancer management. We transform patient care through genomic characterization of tumors and ultrasensitive detection of disease recurrence or progression. To achieve this, we leverage whole-genome, exome, and bespoke targeted sequencing with proprietary algorithms to provide unmatched genetic accuracy. Join a world-class, multidisciplinary team to drive impactful R&D projects to improve our cutting-edge clinical offerings. Your work will advance a new generation of precision medicine products used by global biopharma and clinicians to transform cancer diagnostics and therapeutics. Responsibilities: Organize and help perform internal proof of principle projects, development projects, and verification and validation exercises for liquid biopsy products in the Personalis portfolio. Work with the broader R&D organization to scope, track and troubleshoot liquid biopsy projects with internal and external collaborators and customers. Collaborate with process development, tech transfer, and operations teams to shepherd early stage products, product revisions, and early projects through to operations. Work with bioinformatics teams to plan experiments and analyze results. Identify problems in current processes and come up with troubleshooting approaches and Participate in meetings and present results. Use effective two-way communication to create and maintain a collaborative working environment. Support and ensure compliance with all department and company policies and procedures. Education and Experience: Ph.D or MS with a minimum of 8 or 12 years of experience. Minimum of 2 years of laboratory experience in NGS and/or liquid biopsy focused molecular biology. Solid

  • Sr. Director, Advanced Technologies

    Fremont, CA

    unspecified $240K-$285K

    Sr. Director, Advanced Technologies Fremont, CA Personalis is a genome-scale diagnostics company with a mission to pioneer genome guided medicine. Our priority is to obtain the most accurate genetic data from each sample, and then to draw the most reliable medically-focused conclusions from these. Our tests are based on whole human genome and exome sequencing, conducted in our state-of-the art laboratory. We analyze results utilizing proprietary databases, advanced human reference sequences, and sophisticated algorithms. Personalis is based in Fremont, California. Summary: We are looking for a dynamic and experienced Senior Director of Advanced Technologies to lead a team in scoping, evaluating, and implementing cutting-edge advancements in sequencing, sample preparation and new assay creation. This role will drive innovation in our proprietary technologies, enhancing performance and expanding capabilities. Your contributions will play a key role in shaping the next generation of genomics-based precision medicine products, supporting immuno-oncology, cancer clinical trials, diagnostics, and therapeutics used by pharma, biotech, hospitals, and clinicians. Responsibilities: Develop and execute the advanced technology strategy, ensuring alignment with company objectives and long-term vision. Lead efforts to evaluate and integrate new technologies that expand and improve Personalis products. Participate in forward-looking strategic planning and influence company-wide technology adoption. Identify new initiatives and build consensus across various stakeholder groups with clear success measures. Work closely with bioinformatics teams to design experiments and validate new procedures and analytics. Partner with the operations teams to ensure the smooth adoption of new technologies. Collaborate across functions to troubleshoot issues and implement solutions that

  • Software Engineer 2

    Fremont, CA

    unspecified $130K-$155K

    Software Engineer 2 Fremont, CA Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California. Summary: We are seeking a Software Engineer II to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment. Onsite: Monday, Tuesday, and Thursday Responsibilities: Design, develop, test, and maintain software systems and features supporting laboratory operations. Develop and optimize backend services and APIs using Python and/or Java. Implement solutions using a variety of database technologies, including relational and graph databases. Take ownership of

  • Sr. Manager/Associate Director, Market Access

    Remote

    remote $160K-$220K

    Sr. Manager/Associate Director, Market Access Remote At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Location: Remote Summary: The Sr. Manager / Associate Director, Market Access will play a critical role in shaping and executing Personalis' commercial payer strategy. This individual will lead strategic engagement with national and regional commercial health plans to expand coverage, influence policy, and improve patient access to Personalis' innovative diagnostic solutions. This role requires a highly strategic, externally facing leader with deep expertise in payer engagement, reimbursement policy, and market access within oncology diagnostics or related healthcare sectors. Key Responsibilities: Strategic Payer Engagement Build and sustain relationships with key decision-makers across national and regional commercial health plans. Educate stakeholders on Personalis' technologies and clinical value to influence favorable medical policy development and coverage decisions. Cross-Functional Collaboration Partner closely with Medical Affairs, Commercial, Legal/Compliance, and Finance teams to align on access strategies and messaging. Contribute to enterprise-wide initiatives that support market access and reimbursement success. External Stakeholder Advocacy Represent Personalis in interactions

  • Supervisor, Lab Operations (PM Shift, Tues - Sat)

    Fremont, CA

    unspecified $72.1-$81.7/hr

    Supervisor, Lab Operations (PM Shift, Tues - Sat) Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: A CLS Supervisor performs and reports on clinical laboratory testing that aids physicians in diagnosing and treating patients. A key part of the role is supervising team members and ensuring that all laboratory procedures are followed for specimen handling, next-generation sequencing (NGS) processes, test analyses, and the accurate maintenance of patient records. In our lab, we foster a positive, friendly, and team-based environment. We all pitch in to achieve our common goals and support each other. You'll work in a dynamic atmosphere, gaining hands-on experience at multiple benches, including extractions, library preparation, and sequencing. You'll also partner with our lab assistants to coordinate pre-analytical and post-analytical tasks. Available Shifts: Sun - Thu, 10:00pm - 6:30am Responsibilities: Perform and report clinical laboratory testing on patient samples to aid physicians diagnose and treat patients. This includes the following areas: Extractions Library Preparation Enrichments Sequencing Handle and process all

  • Sr. IT Support Specialist (Temp)

    Fremont, CA

    unspecified $36-$44/hr

    Sr. IT Support Specialist (Temp) Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: The Sr. IT Support Specialist will provide all levels of support for our corporate IT operations including executive (C-level) staff. We are seeking candidates who pride themselves on excellent customer service techniques, troubleshooting skills and who possess a desire to learn and implement new technologies in a rapidly growing environment. Onsite: Tue-Sat from 1:30 pm - 10:00 pm Responsibilities: Image and support Windows and MacOS laptops. Respond to service desk requests and support tickets, emails and calls. Troubleshoot tier one, two and three IT Support issues and assist junior IT personnel. User and group management in Active Directory and in OKTA IdP. Respond to and troubleshoot any infrastructure outages. Support and maintain email and teleconferencing systems and clients. Respond to and maintain anti-virus and patch management systems. Maintain inventory for hardware and software. Maintain accurate and comprehensive documentation and standard operating procedures. New hire onboarding and termination offboarding of

  • Director, Commercial Marketing

    Remote

    remote $220K-$250K

    Director, Commercial Marketing Remote At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: Personalis is building its position as a leader in precision oncology and is seeking a Director of Commercial Marketing to assume a key commercial leadership role. This team leader will own the strategic direction and tactical implementation of commercial marketing activities across the full portfolio, including tumor profiling and MRD. The Director will be responsible for a multitude of global marketing activities aimed at building awareness and driving demand across several customer segments. This position will own a broad spectrum of upstream and downstream marketing activities including brand planning, commercial market research, branding, lead generation, website management, creative development, asset development, campaign activation, and multi-channel marketing. This position will also co-own strategic marketing deliverables including go-to-market strategy, customer segmentation, product positioning, and messaging in collaboration with key partners. This leader will oversee a team of marketers to support commercial growth objectives, with the potential to grow and scale a best-in-class team as

  • Clinical Lab Scientist 1 (3rd Shift)

    Fremont, CA

    unspecified $56.25-$66/hr

    Clinical Lab Scientist 1 (3rd Shift) Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: In our lab, we foster a positive, friendly and team-based environment where we all pitch in to help achieve our common goals and support each other. We offer a dynamic atmosphere where you will have the opportunity to work on multiple benches such as extractions, Library prep, and sequencing. You will also partner with our lab assistants and coordinate with them on pre-analytical & post analytical tasks. Our Clinical Lab Scientists perform and report clinical lab testing on samples used by physicians in the diagnostic and treatment of patients. This will entail following the laboratory's procedures for specimen handling and next generation sequencing processes, test analyses, reporting and maintaining records of patient test results. Onsite: 5 days a week Available Shifts: Tuesday - Saturday, 10:00pm - 6:30 am Sunday - Thursday, 10:00pm - 6:30 am Thursday - Monday, 10:00pm - 6:30 am Training hours may be at different

  • Sample Accessioner 1 (Temp)

    Fremont, CA

    unspecified $24-$25/hr

    Sample Accessioner 1 (Temp) Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: This role offers the opportunity to gain experience in a fast paced cutting edge clinical lab environment. The Sample Accessioner will work in a team environment which includes project managers and clinical lab ops specialists. As an Accessioner, daily tasks will involve patient specimen intake, accessioning and fulfilling client requests for returns or destructions. This will entail following SOPs and working with Laboratory Information Management System (LIMS) and other software. This role will also perform shipping / receiving, recording and inventorying of samples sent for laboratory testing. Available Shifts: Mon-Fri, 10:30 am - 7:00 pm OR Tues - Sat, 10:30am - 7:00pm Responsibilities: Confirming daily incoming specimens such as blood, plasma, and tissue meet acceptability standards for testing Labeling specimens with associated unique lab identifiers & maintaining sample inventory logs. Promptly fulfill client requests to return or destroy specimens. Prepare and ship specimens to various client testing sites. Logging test

  • Sr. Payroll Analyst

    Fremont, CA

    unspecified $98K-$115K

    Sr. Payroll Analyst Fremont, CA Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform ® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Days Onsite: Monday & Tuesday (Hybrid) Summary: The Sr. Payroll Analyst is responsible for processing the Company's payroll using the ADP platform on a regular basis in accordance with the Company's policy and ensuring accurate reflection of payroll data in the financial statements. This position will work closely with Accounting and Human Resources team members to perform the scope of work, and provide exceptional service to the entire employee base. The position will also flex to support other areas in accounting, as needed. Responsibilities: Responsible for full cycle processing of all payroll functions including, time & attendance, time-off, security master, reporting, and workflow administration for all U.S. employees. Prepare accounting transactions, including journal entries for semi-monthly

  • Director, Lab Operations

    Fremont, CA

    unspecified $210K-$245K

    Director, Lab Operations Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: We are seeking an accomplished and strategic Director of Laboratory Operations to lead and scale our NeXT Personal laboratory. In this high-visibility role, you will drive operational maturity, ensuring our high-complexity liquid biopsy laboratory functions at the gold-standard. Beyond overseeing daily operations, you will have the autonomy to shape the future of the lab, reporting directly to the VP of Operations with full accountability for departmental AOPs and OKRs. As a Director of Laboratory Operations, you will lead a multidisciplinary team of supervisors and associates to meet increasing demand, directly influencing patient outcomes in oncology. By joining us, you become a catalyst for growth, driving continuous improvement across our RUO, GLP, and CLIA/CAP operations. We are looking for a leader who thrives in a "Team Above Self" environment - someone who will act as a dedicated mentor to develop the next generation of laboratory leaders while ensuring that every sample processed

  • Molecular Account Executive

    Remote

    remote Salary not disclosed

    Molecular Account Executive Remote At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Locations: Florida, Upstate New York, or New York City Summary: At Personalis, we are committed to providing clinicians with testing insights that take personalized medicine to the next level. The Molecular Testing Account Executive will be responsible for territory development by promoting Personalis' novel suite of molecular testing into surgery and oncology clinics. We are seeking passionate sales professionals with a track record of launching products and creating deep client relationships. Responsibilities: Drive strategic business expansion/collaboration opportunities via: Community and academic Breast, Thoracic, and Colorectal Surgeons Major U.S. cancer centers and clinics / Top 20 largest oncology practices in the territory Collaboration with commercial alliance partners Develop and implement a comprehensive business plan for the territory that will be inclusive of priorities, territory management, goal setting, etc. Continually analyze competitive landscape and environment within assigned accounts to determine trends and provide customer feedback to Personalis leadership Monitor performance of sales to ensure objectives

  • Quality Associate 2

    Fremont, CA

    unspecified $85K-$95K

    Quality Associate 2 Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Days Onsite: Tuesday - Saturday from 9:30am - 6pm Summary: The QA Specialist is an integral member of the Quality team. The primary responsibilities are to assist in the implementation and management of the Quality Management System. This individual helps drive the Quality Management System implementation in accordance with CLIA, CAP, ISO 15189, ISO 13485, 21 CFR 820 and other regulations and guidance as applicable. The Sr. QA Specialist has knowledge and experience working in ISO 15189 and/or ISO 13485 or 21 CFR 820 regulated environments and sufficient knowledge and experience working in Quality to operate with minimal supervision. This role will be required to work an offset schedule (e.g. Tueday through - Saturday) to ensure support for the Reagent Manufacturing and Clinical Laboratory Operations over the weekend.This position reports to the Director of Quality Assurance. Responsibilities: Timely performance of Quality review and audits of Clinical Study data in compliance with GCP

  • Sr. Lab Process Automation Engineer

    Fremont, CA

    unspecified $135K-$165K

    Sr. Lab Process Automation Engineer Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: The Senior Process Automation Engineer within the Research, Product Development and Technology Transfer Group contributes to the development and implementation of automation systems and workflows to support the processing of samples in a clinical diagnostics and research laboratory environments. This individual collaborates within a team of scientists and engineers upon projects to conceptualize, design, develop, and implement solutions designed to optimize the performance and increase the efficiencies of the laboratory processes. Responsibilities: Principal responsibilities of this position include automation projects leadership. Lead the development and integration of the automation systems and related software tools, preparing the documentation for equipment validation and operating procedures. Develop scripts for liquid handling robots and other lab automation instruments. Building rapport with end-users, lab supervisors and process owners, and coordinate with cross functional teams to ensure the successful implementation in the labs. Define and lead the automation systems development, testing and qualification requirements. Support

  • Client Experience Specialist

    Fremont, CA

    unspecified $63K-$76K

    Client Experience Specialist Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Hybrid - Onsite on Monday & Tuesday Summary: As a Client Experience Specialist, you will be at the forefront of our commitment to providing excellent service as we grow our diagnostic business. You will play a key role in supporting the company's clinical testing operations by ensuring a seamless experience for both patients and oncology offices. Our client experience specialists are instrumental in managing the intake, coordination and follow up of test orders. You will be responsible for communicating with patients, physician's offices and pathology labs, as well as collaborating closely with key stakeholders including laboratory operations, clinical staff, patient billing and commercial functions. The ideal candidate will demonstrate strong communication and organizational skills, as well as a commitment to delivering high quality service in a fast paced, patient centered environment. If you are passionate about improving the customer experience and thrive in a dynamic environment, we invite you to apply for

  • Clinical Lab Associate 1

    Fremont, CA

    unspecified $27.5-$34.6/hr

    Clinical Lab Associate 1 Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Shifts Available: Friday - Tuesday: 10pm - 6:30am (3rd Shift) Tuesday - Saturday: 10pm - 6:30am (3rd Shift) Training hours may be different from your shift schedule. Responsibilities: Perform nucleic acid extraction from various sample types in a Biosafety Level 2 laboratory (e.g., FFPE, blood, plasma, and more) Quantify extracted materials by following QC protocols Prepare extracted materials for library prep using automated and manual procedures. Record sample processing workflows in real-time through a Laboratory Information Management System (LIMS) Maintain robotic liquid handlers and other instruments for optimal performance Assists in data transfer and basic QC evaluation of data Perform troubleshooting and system evaluations when necessary, in communication with the automation support team, laboratory supervisor, and/or third-party technical support teams Escalates issues to a supervisor when problems arise with sample processing Maintain appropriate supplies and equipment to maximize department efficiency and meet established budgetary and quality goals Support and ensure compliance

  • Clinical Research Associate 2

    Fremont, CA

    unspecified $120K-$145K

    Clinical Research Associate 2 Fremont, CA Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California. Days Onsite: Monday & Tuesday (Hybrid) Summary: The Clinical Research Associate is responsible for managing clinical operations projects, which includes biospecimen management, GCP documentation, and compliance requirements related to Personalis clinical research studies and CRO partnerships. This individual will require an understanding of oncology molecular testing using Next Generation Sequencing (NGS) platforms, medical devices, and will interact with external partners to execute clinical operations, monitoring, regulatory, and clinical quality documentation. Responsibilities: Lead clinical operations activities. Manage Clinical study operations (internal and external) in coordination with CRO, IRB, regulatory, and quality teams. Support the program sponsor in preparation of clinical study operations. Collaborate in the execution of clinical validation studies to

  • Sr. Network and Infrastructure Engineer

    Fremont, CA

    unspecified $150K-$170K

    Sr. Network and Infrastructure Engineer Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Onsite: Monday, Tuesday & Thursday Summary: We are seeking a highly skilled and versatile Senior Network & Infrastructure Engineer to join our growing team. This role is designed for a technical "bridge" builder-someone who possesses deep expertise in high-performance networking (HPC) and Cisco security, but who is also comfortable managing a modern, hyperconverged infrastructure stack. The successful candidate will lead the architecture and maintenance of our Cisco Nexus fabric, secure our perimeter with NextGen firewalls, and support a robust environment consisting of VxRail, VMware, and petabyte-scale HPC storage. You will be equally at home in a CLI environment as you are performing hands-on hardware management within our colocation data centers. Responsibilities: Network & Security Architecture (60%) HPC Networking: Architect, deploy, and optimize Cisco Nexus switches within a High-Performance Computing (HPC) environment, ensuring low latency and high throughput. Security & Firewalls: Full lifecycle management of Cisco NextGen Firewalls (NGFW) . You

  • Scientist, Reagent Process Development

    Fremont, CA

    unspecified $120K-$150K

    Scientist, Reagent Process Development Fremont, CA At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: We are seeking a results-driven, hands-on Process Development Scientist to join our exciting team. In this role, you will be responsible for translating R&D breakthroughs into reagent production processes, specifically focusing on formulations, packaging, and QC assays/specifications. This position bridges R&D and Manufacturing, ensuring that new products are robust, scalable, cost-effective, and compliant with ISO 13485/GMP standards. Responsibilities: Formulation Process Development: Develop and optimize manufacturing methods for reagent formulations to ensure consistency, functionality, and stability. Reagent Packaging Process Development: Design and implement accurate and reproducible filling, dispensing, labeling, and sealing processes for liquid reagents into tubes and multi-well plates. Scale-Up: Transition laboratory-scale formulations and manual filling processes into robust, automated, or semi-automated production-scale processes. Evaluate outsourcing to contract manufacturers, as needed. Design scaled up and practical manufacturing processes, while identifying Critical Process Parameters and Critical Quality Attributes. QC Assay Development & Specs: Develop relevant in-process and finished product test methods

  • Sr. Bioinformatics Scientist – Novel Cell Free DNA Applications

    Fremont, CA

    unspecified $155K-$190K

    Sr. Bioinformatics Scientist – Novel Cell Free DNA Applications Fremont, CA Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency. Days Onsite: Monday & Tuesday Summary: The Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Senior Bioinformatics Scientist will work closely with our clinical evidence generation teams, applying our cell-free technology solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection. Responsibilities: Design and develop novel cell-free technologies and products Collaborate closely with laboratory scientists to design experiments to develop and evaluate novel applications for cell-free DNA assays Draw on deep experience with genomics