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Nautilus Biotechnology

10 open roles indexed with location, benefit, and apply-link signals where available.

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  • Director, Services & Support

    San Carlos, 835 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Director, Services & Support San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are seeking a Director, Service & Support to join our team. This leader will oversee post-commercialization support for our instruments, assays, and software, ensuring customers receive exceptional technical, scientific, and service assistance. The successful candidate will help establish and continuously improve our product support program for the platform instrument, beginning with support for in-house users at the San Carlos office. You'll collaborate closely with Systems Integration, Engineering, and Software teams to gain comprehensive expertise in our Proteomic Analysis System. Prior experience with optics, fluidics, mechanics, or computing is highly desirable. This role reports to the Chief Financial Officer and is based in San Carlos, CA. Responsibilities Leadership & Strategy · Contribute to the development and implementation of service revenue models, such as contracts, extended warranties, and training programs. · Support the formulation and implementation of

  • Senior Director, IT

    San Carlos, 835 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Senior Director, IT San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. As the Senior Director of IT , you will drive the technological vision of our company, ensuring our systems are scalable, secure, and innovative. This role requires a forward-thinking leader who thrives in a fast-paced environment, can plan strategically, work tactically, and be hands-on in implementation. This position will report to the Senior Director of Software Engineering and IT, and will be located in San Carlos, CA. Responsibilities - Develop and implement IT strategies that align with organizational goals. - Combine strategic leadership with practical, day-to-day technical engagement to drive reliable operations across infrastructure, hardware, networking, systems management, ensuring reliability, scalability, and performance. - Ensure data security, compliance, incidence response and disaster recovery protocols are in place. - Oversee and own IT budgets, vendor relationships, and procurement processes to ensure cost-effective and value-driven technology investments. - Provide

  • Sr. Field Support Engineer

    San Carlos, 1561 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Sr. Field Support Engineer San Carlos, 1561 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are hiring for a Senior Field Support Engineer to join our growing team. The Field Support Engineer is responsible for installing, supporting, and improving complex biotech instrumentation onsite and in customer environments. This role sits at the intersection of customers, engineering, manufacturing, and quality, ensuring high system availability while driving rapid learning and product improvement during early commercialization. This position is hands-on, customer-facing, and requires strong technical troubleshooting skills combined with disciplined documentation and feedback into design, manufacturing, and quality systems. Responsibilities • Install, commission, and qualify instruments internally and at customer sites • Diagnose and resolve hardware, software, fluidic, optical, and electromechanical issues • Perform preventative and corrective maintenance to maintain target system uptime • Respond to internal and external customer escalations • Provide on-site and remote technical support • Represent the company professionally

  • Senior Research Associate

    San Carlos, 835 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Senior Research Associate San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are looking for a skilled and motivated Senior Research Associate to join our affinity reagent discovery team. In this role, you will be a hands-on contributor to discovery campaigns including affinity reagent selection and characterization - from library panning through functional validation. You will provide both technical depth and the flexibility in a fast-moving, multi-project environment. Responsibilities - Execute and optimize phage display panning campaigns to identify and enrich antigen-specific affinity reagent clones - Perform high-throughput screening and characterization using a variety of techniques, including ELISA, western blot, biolayer interferometry (BLI) and the Nautilus proteomics platform - Carry out molecular cloning workflows supporting antibody reformatting, expression construct design, and recombinant protein production - Culture mammalian cells (e.g., HEK293) for transient and stable protein expression - Contribute to data recording, experiment tracking, and reagent management within a

  • Associate Director, Affinity Reagent Development and Characterization

    San Carlos, 835 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Associate Director, Affinity Reagent Development and Characterization San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are seeking a visionary and execution-oriented Associate Director, Affinity Reagent Development and Characterization , to serve as a leader and scientist driving the affinity reagent development pipeline from initial candidate discovery through molecular characterization of binding interactions. This role is critical for expansion of the binders used in the Nautilus platform assay. The ideal candidate combines hands-on scientific expertise with leadership skills and strategic drive. The Associate Director will oversee teams focused on library panning, antibody production, affinity maturation, and bioanalytical chemistry. In addition, the candidate will be expected to work closely with other leaders to ensure that affinity reagents binding characteristics are well understood and are performant within our single-molecule proteomics assay. Responsibilities - Lead a high performing team with a mandate that spans from affinity reagent discovery and optimization to

  • Senior Manufacturing Engineer

    San Carlos, 1561 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Senior Manufacturing Engineer San Carlos, 1561 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are seeking a highly motivated Senior Manufacturing Engineer with expertise in biotechnology hardware to join our manufacturing team. The ideal candidate will play a key role in scaling and optimizing the production of our proteomics platform. The candidate will collaborate with R&D, supply chain and contract manufacturing to ensure the highest product quality and most efficient production. This role involves developing and refining manufacturing processes, troubleshooting hardware issues, and driving continuous improvements in production efficiency and reliability. Responsibilities - Create and maintain accurate documentation of work instructions, processes, and procedures. - Assist in preparing reports on system performance and status. - Experience with process validation and scaling up from pilot to production. - Proficiency in design for manufacturability and reliability. - Drive continuous improvement initiatives in product design and manufacturing processes to enhance product quality, reliability,

  • Senior Director, Bioinformatics

    San Carlos, 835 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Senior Director, Bioinformatics San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are looking for a Sr. Director of Bioinformatics to join our growing company. Being successful in our goal of delivering novel proteomic insights to the world hinges on our ability to analyze and understand large, complex, and diverse data sets that result from our experimental efforts, surfacing any key insights that might be hidden within. A candidate stepping into this highly visible role will provide both technical and people leadership for diverse bioinformatics teams and work with R&D leaders to define strategic direction. Our novel proteomic technology is in its formative stages, which means that anyone in this role will have an outsized impact on our technology and customer success. This position will report to the SVP of Product Development and is located in San Carlos, CA. A minimum of three days per week in office

  • Senior Scientist, Chip and Surface Chemistry

    San Carlos, 1561 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Senior Scientist, Chip and Surface Chemistry San Carlos, 1561 Industrial Road, San Carlos, California, USA At Nautilus, our mission is to transform global health by harnessing the potential of the proteome to accelerate drug discovery and advance the era of precision and personalized medicine. We are pioneering the development of a single-molecule protein analysis platform distinguished by its exceptional sensitivity, scalability, and ease of use-aimed at democratizing access to the proteome, one of biology's most dynamic and valuable sources of insight. Achieving this vision requires rigorous scientific innovation paired with an entrepreneurial spirit, and we are assembling a world-class team of talented builders, innovators, and visionaries from diverse fields. We are seeking a highly qualified Senior Scientist to enhance the functionality and reliability of our platform's flow cell and surface chemistry components. The ideal candidate will possess a strong background in surface chemistry and process development, with the ability to apply their expertise across domains such as assay development, metrology, data analysis, and system integration. Responsibilities • Collaborate with lead scientists and engineers to develop and validate processes related to nanofabrication, surface chemistry, and flow cell assembly. • Design and implement analytical and functional methodologies to characterize and assess the effectiveness of chip patterning, surface chemistry, and flow cell assembly processes. • Test and implement assay, flow cell, and surface chemistry improvements on Nautilus' proteomics platform. • Apply statistical process control methods to establish and maintain control and specification limits. • Experience with DNA origami design, fabrication, and integration in

  • Senior Product Support Engineer

    San Carlos, 1561 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Senior Product Support Engineer San Carlos, 1561 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are hiring for a Senior Product Support Engineer to join our growing team. The Product Support Engineer is responsible for installing, supporting, and improving complex biotech instrumentation onsite and in customer environments. This role sits at the intersection of customers, engineering, manufacturing, and quality, ensuring high system availability while driving rapid learning and product improvement during early commercialization. This position is hands-on, customer-facing, and requires strong technical troubleshooting skills combined with disciplined documentation and feedback into design, manufacturing, and quality systems. Responsibilities • Install, commission, and qualify instruments internally and at customer sites • Diagnose and resolve hardware, software, fluidic, optical, and electromechanical issues • Perform preventative and corrective maintenance to maintain target system uptime • Respond to internal and external customer escalations • Provide on-site and remote technical support • Represent the company professionally

  • Sr. Cost Accountant

    San Carlos, 835 Industrial Road, San Carlos, California, USA

    unspecified Salary not disclosed

    Sr. Cost Accountant San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are seeking an exceptional individual to join our growing team in our dynamic, early-stage biotech company. The Sr. Cost Accountant is responsible for creating and maintaining accurate process cost information, comparing standard costs to actual costs, managing perpetual inventory system, and owning the month-end close and budgeting process for inventory/cost. Additionally, they will develop and maintain a cost accounting system to reduce costs and improve profitability. This role requires an experienced professional in manufacturing and cost accounting to collaborate with various departments such as procurement, production, inventory control, and IT to establish best-in-class manufacturing cost accounting, reporting, and operational practices. The role requires strong technical depth, independent judgment, and the ability to influence cross-functional partners through expertise This position will report to the Corporate Controller. Responsibilities - Oversee and assist with execution of the daily operations