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Associate Director, Affinity Reagent Development and Characterization

Nautilus Biotechnology - San Carlos, 835 Industrial Road, San Carlos, California, USA

Posted Mar 20, 2026

Benefits

Parental leave
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Non-birth-parent leave
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Family-building benefits
  • Fertility benefits: Not verified
  • Adoption assistance: Not verified
  • Surrogacy assistance: Not verified
Mental health support
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Relocation assistance
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Childcare support
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Learning budget
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Verification
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Salary
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401(k) match
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Market context

U.S. role benchmark (BLS OEWS)
$116,543 U.S. median for this role
Projected growth (BLS Employment Projections)
+9.8% - Much faster than average

Matched to SOC 15-1252 - Software Engineering aggregate by role bucket.

Source: U.S. Bureau of Labor Statistics, OEWS, May 2024 and Employment Projections, 2024-2034.

Role

Role function
Engineering From the posting source checked Jun 20, 2026
Seniority
Director Plus From the posting source checked Jun 20, 2026

Schedule

Shift type
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Weekend work
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Company

Company stage
Early From the posting source checked Jun 20, 2026
Equity
Offered Verified - SEC 10-K source checked Jun 20, 2026

Application

Cover letter
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Assessment
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Deadline
Not stated

Where they hire

State eligibility is not yet verified.

About this role

Associate Director, Affinity Reagent Development and Characterization San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are seeking a visionary and execution-oriented Associate Director, Affinity Reagent Development and Characterization , to serve as a leader and scientist driving the affinity reagent development pipeline from initial candidate discovery through molecular characterization of binding interactions. This role is critical for expansion of the binders used in the Nautilus platform assay. The ideal candidate combines hands-on scientific expertise with leadership skills and strategic drive. The Associate Director will oversee teams focused on library panning, antibody production, affinity maturation, and bioanalytical chemistry. In addition, the candidate will be expected to work closely with other leaders to ensure that affinity reagents binding characteristics are well understood and are performant within our single-molecule proteomics assay. Responsibilities - Lead a high performing team with a mandate that spans from affinity reagent discovery and optimization to

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