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Senior Research Associate

Nautilus Biotechnology - San Carlos, 835 Industrial Road, San Carlos, California, USA

Posted Apr 14, 2026

Benefits

Parental leave
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Non-birth-parent leave
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Family-building benefits
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Mental health support
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401(k) match
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Market context

U.S. role benchmark (BLS OEWS)
$111,944 U.S. median for this role
Projected growth (BLS Employment Projections)
+13.7% - Much faster than average

Matched to SOC 15-1252 - Data and ML aggregate by role bucket.

Source: U.S. Bureau of Labor Statistics, OEWS, May 2024 and Employment Projections, 2024-2034.

Schedule

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Weekend work
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Application

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Deadline
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Where they hire

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About this role

Senior Research Associate San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are looking for a skilled and motivated Senior Research Associate to join our affinity reagent discovery team. In this role, you will be a hands-on contributor to discovery campaigns including affinity reagent selection and characterization - from library panning through functional validation. You will provide both technical depth and the flexibility in a fast-moving, multi-project environment. Responsibilities - Execute and optimize phage display panning campaigns to identify and enrich antigen-specific affinity reagent clones - Perform high-throughput screening and characterization using a variety of techniques, including ELISA, western blot, biolayer interferometry (BLI) and the Nautilus proteomics platform - Carry out molecular cloning workflows supporting antibody reformatting, expression construct design, and recombinant protein production - Culture mammalian cells (e.g., HEK293) for transient and stable protein expression - Contribute to data recording, experiment tracking, and reagent management within a

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