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Senior Manufacturing Engineer

Nautilus Biotechnology - San Carlos, 1561 Industrial Road, San Carlos, California, USA

Posted Mar 16, 2026

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About this role

Senior Manufacturing Engineer San Carlos, 1561 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. We are seeking a highly motivated Senior Manufacturing Engineer with expertise in biotechnology hardware to join our manufacturing team. The ideal candidate will play a key role in scaling and optimizing the production of our proteomics platform. The candidate will collaborate with R&D, supply chain and contract manufacturing to ensure the highest product quality and most efficient production. This role involves developing and refining manufacturing processes, troubleshooting hardware issues, and driving continuous improvements in production efficiency and reliability. Responsibilities - Create and maintain accurate documentation of work instructions, processes, and procedures. - Assist in preparing reports on system performance and status. - Experience with process validation and scaling up from pilot to production. - Proficiency in design for manufacturability and reliability. - Drive continuous improvement initiatives in product design and manufacturing processes to enhance product quality, reliability,

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