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Senior Director, IT

Nautilus Biotechnology - San Carlos, 835 Industrial Road, San Carlos, California, USA

Posted May 22, 2026

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About this role

Senior Director, IT San Carlos, 835 Industrial Road, San Carlos, California, USA At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. As the Senior Director of IT , you will drive the technological vision of our company, ensuring our systems are scalable, secure, and innovative. This role requires a forward-thinking leader who thrives in a fast-paced environment, can plan strategically, work tactically, and be hands-on in implementation. This position will report to the Senior Director of Software Engineering and IT, and will be located in San Carlos, CA. Responsibilities - Develop and implement IT strategies that align with organizational goals. - Combine strategic leadership with practical, day-to-day technical engagement to drive reliable operations across infrastructure, hardware, networking, systems management, ensuring reliability, scalability, and performance. - Ensure data security, compliance, incidence response and disaster recovery protocols are in place. - Oversee and own IT budgets, vendor relationships, and procurement processes to ensure cost-effective and value-driven technology investments. - Provide

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