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Iambic Therapeutics

17 open roles indexed with location, benefit, and apply-link signals where available.

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  • Senior Clinical Trial Manager, Clinical Operations

    Remote - US, San Diego, California, United States

    remote Salary not disclosed

    Senior Clinical Trial Manager, Clinical Operations Remote - US, San Diego, California, United States JOB SUMMARY The Senior Clinical Trial Manager, Clinical Operations, serves as the operational lead for assigned early-phase oncology studies, providing end-to-end trial leadership from start-up through close-out. In close partnership with Clinical Development, Regulatory, Biometrics, and external CROs, this role drives high-quality, inspection-ready trial execution within a collaborative, growth-stage biotech environment. The Senior CTM is accountable for vendor oversight, risk management, timeline and budget performance, and cross-functional alignment to ensure studies are delivered efficiently and in compliance with global regulatory requirements, ICH-GCP, and company SOPs. This position reports to the Director of Clinical Operations and can be remote or onsite in San Diego. KEY RESPONSIBILITIES - Provide end-to-end operational leadership for complex clinical trials from start-up through close-out, ensuring delivery on time, within budget, and in compliance with global regulations and company SOPs - Lead cross-functional study teams and drive alignment across Clinical Development, Regulatory, Biometrics, and external partners - Develop and execute enrollment, site management, and monitoring strategies to ensure high-quality trial conduct and performance - Oversee CRO and vendor performance, including KPI management, monitoring quality oversight, document review and approval, and vendor selection support - Partner with Data Management and Medical to conduct ongoing data review and ensure timely query resolution - Develop and manage key study documents and operational tools, including protocols, informed consent forms, project plans, budgets, and study materials. - Lead study-related training for investigators, site personnel, and internal teams. -

  • Software Engineer I/II, Machine Learning

    Boston Office, Boston, MA, US

    unspecified $130K-$162K

    Software Engineer I/II, Machine Learning Boston Office, Boston, MA, US JOB SUMMARY We are seeking a talented and motivated ML Software Engineer (I/II) to join the software platform group at Iambic Therapeutics. You will build, deploy, and operate ML systems that power our drug discovery efforts. You will work with our multi-disciplinary team to make production ML lifecycle workflows (training/finetuning, evaluation, inference), streamline deployment of GPU-accelerated applications, and collaborate with ML scientists to translate models into reliable, scalable software. This position will be Hybrid and located in our Boston, MA office. (Back Bay) KEY RESPONSIBILITIES - Design, implement, and maintain production-grade ML workflows (fine-tuning, batch/online inference, evaluation) with strong observability and CI/CD. - Deploy GPU-accelerated ML services and jobs using modern tooling and cloud-based orchestration. - Collaborate with ML scientists and cross-functional teams to capture requirements, scope milestones, and deliver features into user workflows and services. - Conduct code reviews and mentor peers on software engineering and MLOps best practices. QUALIFICATIONS - Engineer I: Minimum of 5 years of related experience with a Bachelor's degree in a scientific field; or 3 years and a Master's degree; PhD with 0-3 years of experience or equivalent work experience. - Engineer II: 8+ years relevant experience with a bachelor's degree in a scientific field; or PhD with 3+ years; or equivalent experience. - Strong modern Python development (packaging, type hints, testing, performance), with experience in building production services and libraries. - Hands-on with ML model lifecycle and tooling (e.g. PyTorch, Hugging Face, vLLM/Triton/ONNX

  • Head of Medical Writing

    Remote - US, San Diego, California, United States, San Diego HQ, Boston Office

    remote Salary not disclosed

    Head of Medical Writing Remote - US, San Diego, California, United States, San Diego HQ, Boston Office JOB SUMMARY The Head of Medical Writing (Senior Director) will lead and build the medical writing function, reporting to the VP of Regulatory. This role will be responsible for delivering high-quality submission-ready development documents to support ongoing clinical-stage programs and upcoming IND submissions, while establishing fit-for-purpose, scalable processes and standards. The ideal candidate is both strategic and hands-on, with the ability to drive document development and address global program objectives while also building infrastructure for future growth, including the thoughtful integration of AI-enabled tools. KEY RESPONSIBILITIES - Lead the planning, authoring, and delivery of key development documents (INDs, protocols, IBs, CSRs, Health Authority responses, briefing documents, etc) - Provide strategic input on document content, messaging, and regulatory expectations - Partner cross-functionally with Clinical, Nonclinical, Medical, Biostats, CMC, and Regulatory teams - Establish and refine medical writing processes, templates, and standards - Implement and manage efficient document workflows and timelines - Support development of abstracts, posters, and presentations for scientific conferences - Evaluate and integrate AI tools to enhance writing quality and efficiency - Manage external vendors and contribute to building internal capabilities over time - Ensure consistency, quality, and accuracy across all deliverables - Advise cross-functional leadership on regulatory communication strategy and global document planning QUALIFICATIONS - Bachelor's degree required; advanced degree (PhD, PharmD, MD) preferred - 15+ years of experience in biotech/pharma, with 10+ years in medical writing, prior experience in smaller

  • Principal Engineer, Cloud Ops

    Boston Office, Boston, MA, US

    unspecified Salary not disclosed

    Principal Engineer, Cloud Ops Boston Office, Boston, MA, US JOB SUMMARY We are seeking a talented and motivated Cloud Ops Engineer to join the tightly integrated technology and drug discovery operation at Iambic Therapeutics. You will work in the Software organization and work closely with the ML organization to help drive the Cloud Ops Roadmap, leading and supporting delivery of the roadmap goals for projects across the organization. You will work with teams developing and deploying Iambic's drug discovery platform, Computational Science applications and Machine Learning models. You will also help deliver and support ISO 27001 compliant Cloud Ops processes. This role is preferably Hybrid in Boston, then East Coast, San Diego, or Remote (with workspace support). KEY RESPONSIBILITIES - Support and contribute to the Cloud Ops roadmap, aligning infrastructure initiatives with business priorities. - Provide technical leadership and drive architecture decisions across platform and infrastructure teams. - Lead the design and evolution of scalable, highly available AWS cloud infrastructure. - Build and operate production systems with a strong focus on reliability, performance, and cost efficiency. - Design and manage cloud networking (VPN, VPC, routing, DNS, load balancing, secure connectivity). - Implement Infrastructure as Code (Terraform) and automate provisioning and operations. - Troubleshoot complex issues across distributed systems, including networking and performance bottlenecks. - Apply security best practices and support the ISO 27001 compliance frameworks. - Improve observability, CI/CD pipelines, and overall operational maturity. - Mentor engineers in Cloud Services and influence Cloud Ops best practices across the org. QUALIFICATIONS

  • Senior Software Backend Engineer, Platform Computing

    San Diego HQ, San Diego, California, United States, Boston Office

    unspecified Salary not disclosed

    Senior Software Backend Engineer, Platform Computing San Diego HQ, San Diego, California, United States, Boston Office JOB SUMMARY We are seeking a Senior Software Backend Engineer, Platform Computing to integrate and operate the compute layer that powers data processing and model inference across Iambic's drug discovery platform. You will work within the Software Platform team, partnering with ML engineers and scientists to ensure production workloads are reliable, performant, and scalable. Your focus will be on integrating and operating compute infrastructure and orchestration systems that enable scientific workflows across the platform. This position will be based at our San Diego Headquarters. KEY RESPONSIBILITIES - Integrate and maintain the compute layer supporting data processing and model inference workflows in production - Ensure reliable and performant execution of workloads through monitoring, troubleshooting, and failure resolution - Operate and extend workflow orchestration systems (e.g., Prefect, Coiled, Modal or similar frameworks) - Support deployment and execution of ML model outputs in production environments - Enable scientific workflows by integrating external data sources and supporting analysis and inference workloads within and outside of Insight (e.g., large-scale assay refits) - Collaborate with ML engineers and cross-functional teams to translate model capabilities into production-ready systems - Integrate new compute capabilities into the platform as they are developed, ensuring scalability and flexibility - Establish and maintain best practices for reliability, observability, and operational support QUALIFICATIONS - 10+ years of relevant experience with a Bachelor's degree; or 8 years and a Master's degree; or equivalent experience - Strong software engineering

  • Senior Director/Executive Director, DMPK

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Senior Director/Executive Director, DMPK San Diego HQ, San Diego, California, United States JOB SUMMARY Iambic Therapeutics is seeking an experienced DMPK leader to lead our Drug Metabolism & Pharmacokinetics function. Reporting to senior leadership, you will define the scientific strategy for DMPK from early discovery through IND-enabling studies. You will collaborate with internal and external partners to plan and execute DMPK studies. This is a high-impact, hands-on leadership role for someone who thrives at the intersection of rigorous science and strategic drug development. KEY RESPONSIBILITIES - Lead and manage all DMPK strategy and execution across Iambic's discovery programs, setting clear goals and ensuring alignment with cross-functional program teams. - Design and oversee non-clinical ADME/PK studies and PK/PD modeling to enable candidate selection and accelerate IND filings. - Serve as the internal DMPK subject matter expert, partnering with medicinal chemistry, biology, toxicology, and clinical teams to interpret data and guide program decisions. - Build and manage a high-performing network of CRO partners and academic collaborators to supplement internal capabilities. - Lead preparation and review of DMPK sections for regulatory submissions including INDs and NDAs; interact with health authorities as needed. - Champion compliance with ICH guidelines, FDA regulations, and industry best practices across all DMPK activities. - Contribute scientific expertise to business development, due diligence, and partnership evaluations. - Stay at the forefront of emerging DMPK science, technologies, and regulatory trends to continuously strengthen the function. QUALIFICATIONS - PhD in Pharmacokinetics, Pharmaceutical Sciences, or closely related discipline or PharmD - 12+

  • Associate Director, Information Security

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Associate Director, Information Security San Diego HQ, San Diego, California, United States JOB SUMMARY We have an established information security program and are looking for a hands-on Associate Director to grow it and take it to the next level. This is a practitioner role as much as a leadership role - you will be directly involved in the work across governance, IT, cloud security, software, and DevOps. The immediate strategic priority is expanding our security posture into the software development lifecycle, embedding cloud security practices across our internally developed SaaS environment, while maintaining and maturing our governance, risk, and compliance foundation. You will work to obtain and maintain our ISO certification, partnering closely with IT leadership, R&D, and the broader organization to continuously raise the security bar across the company. This role reports to the VP of IT and carries significant visibility to the CTO and senior leadership. This role is Hybrid based in San Diego HQ or Boston, MA preferred KEY RESPONSIBILITIES - Drive and mature the company-wide information security program and strategy including managing policies, standards, risk assessments, and the enterprise risk register - Act as the primary internal authority on information security operations, advising leadership and department heads on risk and priorities - Develop security metrics and reporting for technical and executive stakeholders - Serve as a working technical mentor to security analysts, providing hands-on guidance, knowledge sharing, and day-to-day direction across IT and cloud security domains - Own ISO 27001 certification and maintenance, including audits, evidence

  • Machine Learning Scientist — Large multimodal models

    Boston Office, Boston, MA, US

    unspecified Salary not disclosed

    Machine Learning Scientist — Large multimodal models Boston Office, Boston, MA, US Job Summary We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. Our mission is to deliver better medicines through innovation in AI-based discovery technologies. In this role, you will research, develop, and scale Enchant - our multimodal transformer model trained on a wide variety of biomedical data - pushing the boundaries of what large-scale foundation models can achieve in drug discovery. This role spans architecture research through to production deployment. You will design and evaluate new model architectures, develop hybrid modeling approaches, optimize training and inference at scale, and work with colleagues across ML and drug discovery to put these models into the hands of scientists making real therapeutic decisions. We are hiring flexibly across levels, from Associate Scientist through Research Scientist II, depending on experience. Key Responsibilities - Research and implement architectural improvements to large-scale multimodal transformer models for biomedical applications - Investigate hybrid modeling approaches that combine learned representations with domain-informed structure or inductive biases - Optimize training pipelines for efficiency, stability, and scalability across many-GPU clusters - Develop and apply inference optimization techniques to support deployment in interactive discovery workflows - Design and maintain benchmarking and evaluation frameworks that track model quality across modalities and downstream tasks - Collaborate with ML and software engineering colleagues to deploy and operationalize models - Partner with computational chemists, medicinal chemists, and biologists to ensure model development is grounded in drug discovery needs

  • Machine Learning Scientist — Agentic data pipelines

    Boston Office, Boston, MA, US

    unspecified Salary not disclosed

    Machine Learning Scientist — Agentic data pipelines Boston Office, Boston, MA, US Job Summary We are seeking a scientist to join our team at Iambic Therapeutics, working on data acquisition and curation for Enchant , our multimodal transformer model trained at scale on a wide variety of biomedical data. In this role, you will design and build agentic systems that acquire, clean, format, and quality-control the large-scale datasets that power Enchant training. You will work at the intersection of LLM-based automation and biomedical data engineering-developing AI agents that can navigate heterogeneous data sources, enforce quality standards, and operate reliably at scale. This role is ideal for candidates who combine strong software engineering instincts with scientific understanding of biomedical data, and who are excited about using LLMs as tools to solve practical data problems. Key Responsibilities - Design, build, and maintain agentic systems for automated data acquisition from public and proprietary biomedical data sources - Develop LLM-based pipelines for data cleaning, normalization, and formatting across diverse data modalities (e.g., molecular, genomic, clinical, literature) - Implement automated quality-control workflows that detect anomalies, flag inconsistencies, and enforce data standards - Evaluate and iterate on agent architectures, prompting strategies, and tool-use patterns to improve reliability and throughput - Collaborate with ML scientists on the Enchant team to understand data requirements and translate them into scalable acquisition and processing systems - Monitor and maintain data pipelines in production, diagnosing failures and improving robustness over time - Document data provenance, processing decisions, and quality metrics to

  • Senior Scientist, Computational Chemistry

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Senior Scientist, Computational Chemistry San Diego HQ, San Diego, California, United States JOB SUMMARY We are seeking a skilled and highly motivated Computational Chemist to join our Computational Sciences group at the Iambic Therapeutics headquarters in San Diego. You will be a key player in the application of advanced ligand and structure-based techniques to drive our drug discovery efforts. You will play an active role in the research teams pursuing important therapeutics across multiple indications. You will work in a cross-functional team, collaborating closely with machine learning scientists, medicinal chemists and biologists to apply cutting edge SBDD methods across hit identification, lead optimization, and candidate selection phases. This is a hands-on role, requiring technical expertise in computational chemistry, a strong interest in the application of co-folding, familiarity with the drug discovery process and a proactive drug-hunter mindset. This role is based in our San Diego Headquarters. KEY RESPONSIBILITIES - Apply a range of ligand and structure-based approaches across hit identification, hit to lead and lead optimization phases (e.g. cheminformatics, pharmacophore modeling, docking and shape-based based virtual screening, de novo molecular design, MD simulation) - Guide design cycles through the identification of structure-activity relationships and the integration of computational predictions with bioactivity data - Partner with medicinal chemists to design, evaluate and prioritize virtual libraries, and propose actionable molecular designs - Partner with ML scientists to integrate SBDD methods with our proprietary transformer-based property prediction technology (Enchant) - Leverage and evolve our proprietary protein-ligand co-folding technology (NeuralPLexer) to yield novel and

  • Software Engineer II, Machine Learning Systems & Productization

    Boston Office, Boston, MA, US

    unspecified Salary not disclosed

    Software Engineer II, Machine Learning Systems & Productization Boston Office, Boston, MA, US JOB SUMMARY Iambic Therapeutics is seeking a Software Engineer to join the NeuralPLexer team, focusing on the engineering systems that enable machine learning research to translate into robust, scalable workflows for drug discovery. This role sits directly alongside ML scientists and emphasizes co-development: helping design, implement, and harden the workflows used to train, evaluate, and apply models on structural (e.g., protein-ligand complexes), affinity, and synthetic data. You will play a key role in turning research code into reliable, reusable systems-without being responsible for core model development. This is a remote position based on the US East Coast. KEY RESPONSIBILITIES - Work embedded with ML scientists to co-develop and refine model training and evaluation workflows - Translate experimental research code into maintainable, well-structured, and reusable systems - Build and expand benchmarking systems for running models on structural and affinity datasets, computing metrics, and supporting reproducible evaluation - Enable rapid iteration by developing tooling and interfaces that expose new capabilities to researchers - Contribute to the ongoing development and productization of NeuralPLexer - Collaborate with platform and infrastructure engineers on scaling workflows where needed, without owning core infrastructure - Perform code reviews and actively mentor best practices in software engineering across the team - Improve reliability, clarity, and reproducibility of ML workflows and supporting systems - Communicate technical work effectively across a cross-functional research and engineering team QUALIFICATIONS Required - 8+ years of software engineering experience (or equivalent), ideally

  • Principal Scientist, Medicinal Chemistry

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Principal Scientist, Medicinal Chemistry San Diego HQ, San Diego, California, United States JOB SUMMARY We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation. This position is on-site at our San Diego Headquarters. KEY RESPONSIBILITIES - Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles. - Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques. - Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions - Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities - Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules - Communicate project updates clearly and effectively to the broader team and key stakeholders - Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork QUALIFICATIONS - BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry - Experience in small molecule drug discovery in

  • Director/Senior Director, Medicinal Chemistry

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Director/Senior Director, Medicinal Chemistry San Diego HQ, San Diego, California, United States JOB SUMMARY We seek an accomplished and creative medicinal chemistry leader with a proven track record of success in advancing drug discovery programs, setting scientific strategy, and leading cross-functional teams to deliver impact. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail leading drug discovery projects, coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, ML-driven molecular generation, property predictions, and bioassay data generation. This position will be on-site at our San Diego Headquarters. KEY RESPONSIBILITIES - Lead a group of project scientists and drive molecular discovery efforts to deliver development and clinical candidates - Devise strategies to execute hit ID, identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles. - Act as a liaison between Iambic, CROs, and other external collaborators, including partnered research projects - Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities - Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules - Contribute to platform development by collaborating with AI/ML and chemistry automation teams to enhance processes and accelerate the design-make-test (DMT) cycle. - Communicate project updates clearly and effectively to the broader team and key stakeholders - Work as a senior

  • Associate Director/Director, Biology (Oncology Drug Discovery)

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Associate Director/Director, Biology (Oncology Drug Discovery) San Diego HQ, San Diego, California, United States JOB SUMMARY Iambic Therapeutics is seeking a highly motivated and experienced Associate Director or Director to lead oncology drug discovery efforts and advance our core mission of accelerating small molecule drug discovery through the integration of experimental and AI/ML-driven approaches. The successful candidate will have a proven track record of driving oncology drug discovery programs and will lead project teams with a deep understanding of the progression of drug candidates from hit identification to IND submission. This role will set scientific direction and drive cross-functional collaboration with Chemistry, DMPK, Safety, and Computational teams. This position is based at our San Diego headquarters. IMPACT & SCOPE - Partner with Iambic's computational and ML scientists to incorporate AI/ML-based tools and models that accelerate data interpretation, hypothesis generation, and decision-making across biology workflows. - This is a high-impact role that influences portfolio strategy and progression. KEY RESPONSIBILITIES - Program leadership: Initiate, direct, and execute biology plans that support medicinal chemistry and translational goals across discovery stages (hit-to-lead, LO, candidate selection, IND-enabling). - Cross-functional integration: Chair or co-lead cross-functional workstreams; align assay strategy with SAR hypotheses, DMPK/PD needs, and safety/translational biomarkers. - Collaboration leadership: Lead or co-lead key scientific collaborations with internal and external partners, driving integration of data and strategy toward shared objectives. - Assay strategy & data integrity: Conceptualize and oversee the design and validation of in vitro and ex vivo assays (signaling, binding, trafficking, imaging, and mechanism

  • Sr Associate Scientist I or II, Medicinal Chemistry

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Sr Associate Scientist I or II, Medicinal Chemistry San Diego HQ, San Diego, California, United States JOB SUMMARY We are seeking a highly skilled and motivated Senior Associate Scientist to join the Chemistry team at Iambic Therapeutics headquarters in San Diego. This position offers the opportunity to work within a dynamic, cross-functional environment, collaborating closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning researchers, and software engineers throughout all stages of discovery, from hit identification and lead optimization through candidate selection. This is a laboratory-based Associate Scientist position that requires strong technical expertise in organic synthesis, catalysis, and medicinal chemistry, as well as hands-on experience in the drug discovery process and a demonstrated “drug hunter” mindset. KEY RESPONSIBILITIES - Design, synthesize, purify, and characterize chemical compounds (10 mg-5 g scale) using modern analytical techniques such as LCMS, HPLC, and NMR, employing both individual and automated parallel synthesis approaches. - Identify and optimize reaction conditions using screening kits and other streamlined methodologies. - Collaborate with the high-throughput experimentation team to ensure the successful execution of parallel chemistry experiments. - Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning. - Partner with computational chemists to leverage machine learning insights for efficient execution of the design-make-test cycle and platform development. - Present results to project teams and senior leadership, clearly communicating data, implications, and recommendations. QUALIFICATIONS - BS in Chemistry with 5+ years experience (pharma/biotech) or MS in Chemistry with 3+ years experience (pharma/biotech).

  • Director, Drug Product Development

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Director, Drug Product Development San Diego HQ, San Diego, California, United States JOB SUMMARY Iambic Therapeutics is seeking a Director , Drug Product Development to lead formulation and process development for small molecule programs from late discovery/IND-enabling through clinical phases, with a clear path to later-stage development, global registrations, and commercialization. This role will set drug product strategy within CMC and drive execution, oversee scale-up, technology transfer, and manufacturing readiness at CDMOs, and ensure high-quality CMC documentation to support global regulatory filings. The successful candidate brings deep subject matter expertise in formulation design and process development to deliver robust, scalable, patient-centric, and cost-effective drug products from early through late phases of clinical development. This role will partner closely with Discovery, Analytical Development, Process Chemistry, Project Management, Quality, Regulatory, Clinical Pharmacology, Clinical Operations, and Supply Chain teams to align development plans, manage risk, and deliver on program timelines. This position will be on-site at our San Diego Headquarters. KEY RESPONSIBILITIES - Serve as the drug product lead in a cross-functional matrix team, defining and driving execution of formulation and manufacturing process strategies in alignment with key stakeholders to meet program objectives. - Lead small-molecule formulation design and development from late discovery through clinical stages, translating biopharmaceutic requirements into patient-centric, clinically viable dosage forms that are manufacturable, stable, and compliant with global regulatory expectations. - Partner with Chemical Process R&D on the DS-DP interface to advance APIs with optimal physicochemical properties (such as solid form, PSD/morphology, pH-solubility, and stability) into clinical development.

  • Research Scientist II/Senior, Discovery ML

    San Diego HQ, San Diego, California, United States

    unspecified Salary not disclosed

    Research Scientist II/Senior, Discovery ML San Diego HQ, San Diego, California, United States JOB SUMMARY We are seeking skilled scientists to join our Discovery ML group at Iambic Therapeutics. In this role, you will be a key player in applying advanced ML techniques to support our drug discovery efforts and will be part of drug discovery teams pursuing important therapeutics across multiple indications. The work will include focus on our flagship machine learning models, including Enchant, our multimodal transformer model for predicting drug-target interactions and molecular properties. This role is based at our San Diego headquarters. KEY RESPONSIBILITIES - Train, fine-tune, and evaluate machine learning models, assessing how they can best be leveraged in a drug-discovery setting and optimizing their performance - Partner with computational chemists, medicinal chemists and biologists to leverage ML insights for decision-making in high-throughput design-make-test-analyze cycles - Generate value, internally and for partners, from our machine learning models, and collaborate with other discovery teams to shape their use - Communicate results with internal drug discovery teams and machine learning scientists and externally with partners - Support the evolution of our machine learning models by gathering analytical feedback and delivering domain-driven guidance to the machine learning team QUALIFICATIONS Required: - PhD or equivalent degree in chemistry or another physical science with 3+ years of experience or commensurate degree and job experience. More junior candidates are welcome to apply, title will reflect experience. - Familiarity with using statistical analysis techniques to evaluate, troubleshoot, and adapt models in scientific