Principal Scientist, Medicinal Chemistry

Benefits

Parental leave

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Non-birth-parent leave

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Family-building benefits

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• Adoption assistance: Not verified
• Surrogacy assistance: Not verified

Mental health support

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Relocation assistance

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Childcare support

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Learning budget

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Verification

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Salary

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401(k) match

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Market context

U.S. role benchmark (BLS OEWS)

$55,390 U.S. median for this role

Projected growth (BLS Employment Projections)

-0.1% - Decline

Matched to SOC 25-2021 - Teaching and Education aggregate by role bucket.

Source: U.S. Bureau of Labor Statistics, OEWS, May 2024 and Employment Projections, 2024-2034.

Role

Role function

Teaching Education From the posting source checked Jun 20, 2026

Seniority

Principal From the posting source checked Jun 20, 2026

Schedule

Shift type

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Weekend work

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Company

Company stage

Growth-stage From the posting source checked Jun 20, 2026

Application

Cover letter

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Assessment

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Deadline

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Where they hire

State eligibility is not yet verified.

About this role

Principal Scientist, Medicinal Chemistry San Diego HQ, San Diego, California, United States JOB SUMMARY We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation. This position is on-site at our San Diego Headquarters. KEY RESPONSIBILITIES - Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles. - Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques. - Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions - Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities - Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules - Communicate project updates clearly and effectively to the broader team and key stakeholders - Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork QUALIFICATIONS - BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry - Experience in small molecule drug discovery in

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