4D Molecular Therapeutics Inc jobs

Clinical Research Associate (Contract) Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY 4DMT seeks a motivated and detail-oriented In-House Unmasked Clinical Research Associate (uIHCRA) to support the Company's clinical trial activities. This position reports to the Unmasked Clinical Trial Manager, Clinical Operations, and will support the day-to-day execution of a Phase 3 clinical trial, including study start-up, conduct, and close-out activities. Role requires extensive

Executive Director, Preclinical and Translational Sciences Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY This Executive Director position will report to the Senior Vice President, Research & Early-Stage Product Development and lead a team of translational scientists and drug development experts tasked with bringing innovative gene therapies to patients. The incumbent will have a high level of passion for 4DMT's mission and the ability

Principal Medical Writer Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: The Principal Medical Writer will support 4D‑150, a gene therapy in late-stage development for retinal vascular diseases, including nAMD and DME, and associated BLA‑enabling activities as well as clinical stage work within the lung program. This role is responsible for the planning, development, and delivery of high‑quality clinical and regulatory documents across late‑stage

R&D Informatics Analyst (Contract) Emeryville, California Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY In this role, you will work both collaboratively within cross-functional teams - including colleagues, consultants, vendors, and MSPs - and independently to support day-to-day operations and project-based initiatives. The primary focus of the role is managing daily operational activities, including Tier 1 and Tier 2 IT Helpdesk support for end users and customers.

Director, Clinical Quality Assurance (CQA) Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY The Director of Clinical Quality Assurance (CQA) will be responsible for Quality Assurance oversight of multiple, global, 4DMT sponsored clinical trials, ensuring trials are executed in compliance with all applicable international regulatory requirements for Good Clinical Practice (GCP). This position reports to the Senior Director, GCP Compliance and Quality Systems and

Clinical Supply Specialist (Contract) Emeryville, California; Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: Reporting to the Director, Supply Chain, this role is expected to work closely within the Supply Chain team, as well as cross-functional groups such as Clinical Operations and Quality. This is a remote or hybrid position. RESPONSIBILITIES: - Supports the development and execution of Clinical Supply strategies for all 4DMT's

Clinical Trial Manager Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: The Clinical Trial Manager will support the Company's clinical trial activities. This position reports to the Director of Clinical Operations. This will be responsible for management of the day to day operations of one or more phase 1-3 clinical trials including trial start up, conduct and close out activities. MAJOR DUTIES & RESPONSIBILITIES:

Senior Quality Specialist (Contract) Emeryville, California Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY 4DMT is hiring a Sr. Quality Specialist, Document & Records Management. Reporting to the Senior Manager, Quality Document & Records Management, the Sr. Quality Specialist will be responsible for ensuring 4DMT's Quality Document & Records Management is designed and executed in an efficient, compliant, and inspection ready manner. This individual will support the

Director, Clinical Operations (Lung Program) Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: Provide strategic and operational leadership for global clinical trial execution across the 4DMT lung portfolio. This role is responsible for delivering clinical programs aligned with corporate timelines, budget, quality, and regulatory expectations while building scalable operational infrastructure appropriate for a fast-paced biotechnology environment. The Director, Clinical Operations will lead internal Clinical

Director, Financial Planning and Analysis Emeryville, California Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY The Director, FP&A - TechOps serves as the primary finance business partner to the TechOps organization, providing end‑to‑end financial leadership across Manufacturing, Supply Chain, CMC Quality, and External Manufacturing as 4DMT transitions from late‑stage clinical development to commercial readiness and launch. This role is responsible for driving financial planning, forecasting, and decision

Registered Nurse- Medical Oncology (Unit 4D) Richmond, Virginia Summary This Registered Nurse- Medical Oncology (Unit 4D) position is located at the Richmond Veterans Affairs Medical Center in Richmond, Virginia. Please learn more about the position below, along with the duties. Duties The Registered Nurse (RN) for Unit 4D provides comprehensive, patient-centered nursing care to adult and geriatric Veterans with complex medical, surgical, oncologic, and rehabilitative needs. The RN delivers evidence-based care, including the safe administration and monitoring of chemotherapeutic agents, in alignment with oncology protocols and patient safety standards. This role requires strong assessment skills, sound clinical judgment, and the ability to respond effectively to rapidly changing patient conditions. The RN collaborates within an interdisciplinary team to coordinate care, support patient and family education, and promote a therapeutic healing environment. This includes monitoring for treatment-related side effects, implementing supportive oncology care, and contributing to quality and safety initiatives that enhance outcomes for Veterans. Duties include, but are not limited to: -Performs comprehensive assessments including physical, psychosocial, and oncology-specific needs. -Administers medications and treatments, including chemotherapeutic agents, in accordance with policy and safety protocols. -Monitors for adverse reactions or complications related to chemotherapy and initiates appropriate interventions. -Coordinates patient care with interdisciplinary team members for timely and effective treatment planning. -Provides patient and family education related to diagnoses, chemotherapy precautions, symptom management, and discharge needs. -Accurately documents all care, assessments, and interventions in the electronic health record. -Participates in unit-based quality improvement and evidence-based practice initiatives. -Maintains a safe, therapeutic environment

Associate Director, Formulation Development Viking Therapeutics, Inc. Associate Director, Formulation Development

Vice President, Clinical Development (Oncology & Molecular Diagnostics) US Remote Vice President, Clinical Development (Oncology & Molecular Diagnostics) Reports to: Chief Medical Officer, Corporate Location: United States (Remote, with up to 30% travel) Position Summary Natera is seeking a Vice President of Clinical Development to deliver absolute ownership over the strategy, design, and execution of Natera-sponsored clinical studies. This corporate leader will institutionalize clinical trial architecture across the enterprise, distinct from therapeutic area strategy, with an immediate focus on defending and expanding our oncology footprint (including Early Cancer Detection and Signatera MRD), alongside corporate-level support for Women's Health and Organ Health. Reporting directly to the Chief Medical Officer, you will be accountable for the operational health, scientific validity, and clinical utility data generated by Natera's multi-million dollar sponsored study portfolio. This is a high-autonomy role for a builder who can navigate rapid structural transitions-specifically our evolution from a Laboratory Developed Test (LDT) framework into highly regulated FDA In Vitro Diagnostic (IVD) and Companion Diagnostic (CDx) pharma partnerships. Key Responsibilities - Portfolio Architecture & Governance: Establish and enforce portfolio-level governance models to monitor study health, site enrollment, milestone delivery, sample flow, and data readiness. Make definitive, data-driven go/no-go decisions on trial modifications, accelerations, or terminations based on objective strategic value and execution feasibility. - Clinical Utility Design: Lead cross-functional teams to design high-impact prospective, observational, and decision-impact trials. Translate clinical questions into protocols that explicitly isolate and prove clinical validity, analytical validity, and decision-impact endpoints to secure broad commercial payer coverage

Clinical Trial Manager Viking Therapeutics, Inc. Clinical Trial Manager

Drug Safety Manager Viking Therapeutics, Inc. Drug Safety Manager

Director of Process Validation Viking Therapeutics, Inc. Director of Process Validation

Medical Science Liaison Director/Lead Viking Therapeutics, Inc. Medical Science Liaison Director/Lead

AI Scientist/Senior, Clinical & Molecular Genomics Modeling, BRAID South San Francisco, California, United States of America Join our team as a Senior AI Scientist, Clinical & Molecular Genomics Modeling and drive innovation in AI and genomics. Develop advanced models to impact clinical trials, integrate complex biological and molecular data, and collaborate with leading researchers. Shape the future of drug discovery with cutting-edge computational science at Roche.

Scientist, 3 Antibody Engineering South San Francisco, California, United States of America Join our team as a Senior Scientist, Antibody Engineering and lead the design and characterization of next-generation antibody therapeutics. Collaborate with multidisciplinary teams, drive innovation, and advance your expertise in molecular biology and protein engineering. Shape the future of healthcare with Genentech's cutting-edge research and development environment.

Senior Scientist, Computational Chemistry San Diego HQ, San Diego, California, United States JOB SUMMARY We are seeking a skilled and highly motivated Computational Chemist to join our Computational Sciences group at the Iambic Therapeutics headquarters in San Diego. You will be a key player in the application of advanced ligand and structure-based techniques to drive our drug discovery efforts. You will play an active role in the research teams pursuing important therapeutics across multiple indications. You will work in a cross-functional team, collaborating closely with machine learning scientists, medicinal chemists and biologists to apply cutting edge SBDD methods across hit identification, lead optimization, and candidate selection phases. This is a hands-on role, requiring technical expertise in computational chemistry, a strong interest in the application of co-folding, familiarity with the drug discovery process and a proactive drug-hunter mindset. This role is based in our San Diego Headquarters. KEY RESPONSIBILITIES - Apply a range of ligand and structure-based approaches across hit identification, hit to lead and lead optimization phases (e.g. cheminformatics, pharmacophore modeling, docking and shape-based based virtual screening, de novo molecular design, MD simulation) - Guide design cycles through the identification of structure-activity relationships and the integration of computational predictions with bioactivity data - Partner with medicinal chemists to design, evaluate and prioritize virtual libraries, and propose actionable molecular designs - Partner with ML scientists to integrate SBDD methods with our proprietary transformer-based property prediction technology (Enchant) - Leverage and evolve our proprietary protein-ligand co-folding technology (NeuralPLexer) to yield novel and

Scientist I, Genotox (Contract) Somerville, Massachusetts, United States Your experience includes… - PhD with 0-2 years of experience in academic or industry setting, MS with 6+ years of experience or BS with 8+ years of experience - Broad knowledge of genome editing technologies and associated off-target discovery assays - Genomic assay development or deployment experience for off-target discovery, verification and structural variation assessment - Familiarity with NGS workflows and library preparation - Deploying PCR-based off-target verification assays such as rhAmpSeq and Hybrid Capture Sequencing - Developing and deploying unidirectional/ligation-mediated PCR assays - Assay related molecular biology techniques including DNA extraction, nucleic acid quality assessment and primer design - Basic cell biology skills including cell line culture and manipulation techniques (electroporation and transfection) - Strong written and verbal communication skills You are interested in… - Developing and deploying assays for genomic safety assessment for the development of Gene Writer candidates - Developing, deploying and analyzing NGS-based assays for off-target discovery and verification - Examining genome structural variants using optical and molecular methods - Working collaboratively with genomic safety, molecular assay, computational biology and regulatory sciences teams to advance Tessera's therapeutic programs - Contributing to scientific report writing, translating complex experimental findings to support regulatory and research goals About you: You are a rigorous, detail-oriented scientist with expertise in genome editing and genomic safety assessment. As a Scientist I on our Genomic Safety team, you will design, develop, and deploy cutting-edge assays to characterize the off-target landscape of our Gene Writer therapeutics

Research Associate II , Molecular Engineering Culver City CA 9522 posted: Posted 4 Days Ago

Senior Scientist, Molecular Biology Cambridge, MA Company Summary: Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. The role We are seeking a highly innovative and driven Senior Scientist, Molecular Biology to lead the design and generation of next-generation DNA constructs enabling programmable medicines. This role is ideal for a scientist who thrives at the intersection of synthetic biology, high-throughput cloning, and computational sequence engineering . You will play a critical role in building scalable platforms for plasmid DNA design, construction, and optimization , leveraging automation, algorithm-driven sequence design, and data-centric workflows . The ideal candidate brings deep technical expertise, creative problem-solving, and a passion for pushing the boundaries of nucleic acid engineering in a fast-paced, entrepreneurial environment. The Senior Scientist will report to the Director of Molecular Biology and is expected to manage a direct report. The role involves close collaboration with other Scientists and group leads across the company as part of a highly collaborative and growing R&D

Senior/Research Associate, Functional Genomics South San Francisco, CA About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position NewLimit is seeking a Senior/Research Associate with experience in molecular biology to join our Epigenetic Editing group. Pooled screening technologies are at the heart of our discovery engine, allowing us to rapidly search for epigenetic reprogramming therapies that restore cell function and reduce the burden of disease. As a member of our team, you will: - Collaborate with our Single Cell Technology team to implement large-scale, single cell perturbation experiments with custom chemistries - Build recombinant DNA vectors by synthesis and cloning to enable large-scale single cell perturbation experiments - Prepare, titer, and apply viral vectors (lentiviral, AAV) to transduce mammalian cell lines and primary cells - Contribute to scaling and improving pooled single cell perturbation screens Requirements - Bachelor's degree in cell biology, molecular biology, or a related natural science or industry experience - 2+ years of work experience in a cell or molecular biology laboratory (academic or industry) - Experience with molecular cloning, nucleic acid analysis (RT-qPCR, gel electrophoresis), and related molecular biology methods - Experience with mammalian cell culture Nice to have - Experience with next-generation