4D Molecular Therapeutics Inc jobs

Principal Medical Writer Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: The Principal Medical Writer will support 4D‑150, a gene therapy in late-stage development for retinal vascular diseases, including nAMD and DME, and associated BLA‑enabling activities as well as clinical stage work within the lung program. This role is responsible for the planning, development, and delivery of high‑quality clinical and regulatory documents across late‑stage

Clinical Research Associate (Contract) Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY 4DMT seeks a motivated and detail-oriented In-House Unmasked Clinical Research Associate (uIHCRA) to support the Company's clinical trial activities. This position reports to the Unmasked Clinical Trial Manager, Clinical Operations, and will support the day-to-day execution of a Phase 3 clinical trial, including study start-up, conduct, and close-out activities. Role requires extensive

Director, Clinical Quality Assurance (CQA) Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY The Director of Clinical Quality Assurance (CQA) will be responsible for Quality Assurance oversight of multiple, global, 4DMT sponsored clinical trials, ensuring trials are executed in compliance with all applicable international regulatory requirements for Good Clinical Practice (GCP). This position reports to the Senior Director, GCP Compliance and Quality Systems and

R&D Informatics Analyst (Contract) Emeryville, California Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY In this role, you will work both collaboratively within cross-functional teams - including colleagues, consultants, vendors, and MSPs - and independently to support day-to-day operations and project-based initiatives. The primary focus of the role is managing daily operational activities, including Tier 1 and Tier 2 IT Helpdesk support for end users and customers.

Executive Director, Preclinical and Translational Sciences Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY This Executive Director position will report to the Senior Vice President, Research & Early-Stage Product Development and lead a team of translational scientists and drug development experts tasked with bringing innovative gene therapies to patients. The incumbent will have a high level of passion for 4DMT's mission and the ability

Clinical Trial Manager Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: The Clinical Trial Manager will support the Company's clinical trial activities. This position reports to the Director of Clinical Operations. This will be responsible for management of the day to day operations of one or more phase 1-3 clinical trials including trial start up, conduct and close out activities. MAJOR DUTIES & RESPONSIBILITIES:

Clinical Supply Specialist (Contract) Emeryville, California; Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: Reporting to the Director, Supply Chain, this role is expected to work closely within the Supply Chain team, as well as cross-functional groups such as Clinical Operations and Quality. This is a remote or hybrid position. RESPONSIBILITIES: - Supports the development and execution of Clinical Supply strategies for all 4DMT's

Director, Clinical Operations (Lung Program) Remote, United States Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: Provide strategic and operational leadership for global clinical trial execution across the 4DMT lung portfolio. This role is responsible for delivering clinical programs aligned with corporate timelines, budget, quality, and regulatory expectations while building scalable operational infrastructure appropriate for a fast-paced biotechnology environment. The Director, Clinical Operations will lead internal Clinical

Senior Quality Specialist (Contract) Emeryville, California Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY 4DMT is hiring a Sr. Quality Specialist, Document & Records Management. Reporting to the Senior Manager, Quality Document & Records Management, the Sr. Quality Specialist will be responsible for ensuring 4DMT's Quality Document & Records Management is designed and executed in an efficient, compliant, and inspection ready manner. This individual will support the

Director, Financial Planning and Analysis Emeryville, California Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company's lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company's lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company's second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY The Director, FP&A - TechOps serves as the primary finance business partner to the TechOps organization, providing end‑to‑end financial leadership across Manufacturing, Supply Chain, CMC Quality, and External Manufacturing as 4DMT transitions from late‑stage clinical development to commercial readiness and launch. This role is responsible for driving financial planning, forecasting, and decision

Registered Nurse- Medical Oncology (Unit 4D) Richmond, Virginia Summary This Registered Nurse- Medical Oncology (Unit 4D) position is located at the Richmond Veterans Affairs Medical Center in Richmond, Virginia. Please learn more about the position below, along with the duties. Duties The Registered Nurse (RN) for Unit 4D provides comprehensive, patient-centered nursing care to adult and geriatric Veterans with complex medical, surgical, oncologic, and rehabilitative needs. The RN delivers evidence-based care, including the safe administration and monitoring of chemotherapeutic agents, in alignment with oncology protocols and patient safety standards. This role requires strong assessment skills, sound clinical judgment, and the ability to respond effectively to rapidly changing patient conditions. The RN collaborates within an interdisciplinary team to coordinate care, support patient and family education, and promote a therapeutic healing environment. This includes monitoring for treatment-related side effects, implementing supportive oncology care, and contributing to quality and safety initiatives that enhance outcomes for Veterans. Duties include, but are not limited to: -Performs comprehensive assessments including physical, psychosocial, and oncology-specific needs. -Administers medications and treatments, including chemotherapeutic agents, in accordance with policy and safety protocols. -Monitors for adverse reactions or complications related to chemotherapy and initiates appropriate interventions. -Coordinates patient care with interdisciplinary team members for timely and effective treatment planning. -Provides patient and family education related to diagnoses, chemotherapy precautions, symptom management, and discharge needs. -Accurately documents all care, assessments, and interventions in the electronic health record. -Participates in unit-based quality improvement and evidence-based practice initiatives. -Maintains a safe, therapeutic environment

Associate Director, Analytical Sciences and Attribute Characterization US- Remote Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23. Role Summary: The Associate Director, Analytical Sciences and Attribute Characterization, oversees structural and functional characterization and comparability studies across Spyre's clinical and late-stage mAb and mAb-mAb combination programs. This role is a key leader within the Analytical Development and Quality Control (ADQC) organization and reports directly to the Vice President. The position provides both strategic and operational leadership for analytical characterization and comparability, in close collaboration with internal process, analytical, and regulatory teams, as well as global CDMO partners. The Associate Director defines phase-appropriate characterization and comparability strategies that support formulation, process, and analytical development, quality control, and regulatory submissions, aligned with regulatory expectations and industry best practices. This role drives proactive planning to ensure efficient advancement of drug candidates through clinical development stages. Key Responsibilities: - Provide strategic and technical leadership for multidimensional biologics characterization to support product understanding and comparability in a phase-appropriate manner, enabling regulatory submissions for clinical development through BLA & MAA, primarily executed through global CDMO partners. - Serve as subject matter expert (SME) in mAb and mAb-mAb combination product molecular characterization and comparability, applying a fit-for-purpose suite of biochemical, biophysical, physicochemical, and functional assays (e.g., advanced mass spectrometry, capillary and

Senior Scientist, Oligonucleotide Therapeutics South San Francisco, CA The Opportunity At the heart of insitro's strategy is to generate multi-modal phenotypic cellular data in our automated laboratories for our cell machine learning platform and utilize high content human clinical, imaging and genetic data in our clinical machine learning platform to unlock and de-risk novel therapeutic targets for drug discovery. Our drug discovery efforts span from small molecules to oligonucleotides. We are seeking a highly motivated scientist to support our growing efforts in the oligonucleotide drug discovery space. This role will report to the head of our oligonucleotide drug discovery. In this role the candidate will get an opportunity to work across targets and therapeutic areas and will be supporting oligonucleotide drug discovery and tech dev encompassing several modalities such as siRNAs, ASOs and mRNA. The ideal candidate will be working in a highly collaborative environment with our therapeutic area scientists, AI/ML scientists, and chemists, to bring transformative medicines to patients faster. You will be joining a vibrant biotech startup that has long-term stability, with significant funding, and in a high-growth phase, and you will have many opportunities to make a significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro's culture, strategic direction, and outcomes. Join us, and help make a difference to patients! This is an onsite role based in insitro's South San Francisco headquarters, coming onsite 3-4 days a week. Responsibilities - Design and optimize siRNA, antisense

Scientist, 3 Antibody Engineering South San Francisco, California, United States of America Join our team as a Senior Scientist, Antibody Engineering and lead the design and characterization of next-generation antibody therapeutics. Collaborate with multidisciplinary teams, drive innovation, and advance your expertise in molecular biology and protein engineering. Shape the future of healthcare with Genentech's cutting-edge research and development environment.

Associate Director, Oligonucleotide Development Waltham, MA Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Associate Director, Oligonucleotide Development will lead the chemical synthesis strategy for PMO and ASO payload molecules, managing execution both internally and across global CDMOs. This role spans the full development lifecycle - from preclinical process and analytical development through GMP manufacture for IND-enabling studies. The role will ensure the delivery of robust, scalable, and cost-effective manufacturing processes, serve as the primary technical lead for external CDMOs, driving aggressive timelines while delivering well-characterized products optimized for our proprietary bioconjugation platform. As a core member of multiple CMC teams, the Associate Director of Oligonucleotide Development will steer the development of preclinical assets and define CMC strategies within a matrixed environment. The role will play a critical role in global regulatory filings (IND, IMPD, etc.) by authoring and reviewing key Module 3 sections. This role is based in Waltham, MA without the possibility of

Senior Scientist, Computational Chemistry San Diego HQ, San Diego, California, United States JOB SUMMARY We are seeking a skilled and highly motivated Computational Chemist to join our Computational Sciences group at the Iambic Therapeutics headquarters in San Diego. You will be a key player in the application of advanced ligand and structure-based techniques to drive our drug discovery efforts. You will play an active role in the research teams pursuing important therapeutics across multiple indications. You will work in a cross-functional team, collaborating closely with machine learning scientists, medicinal chemists and biologists to apply cutting edge SBDD methods across hit identification, lead optimization, and candidate selection phases. This is a hands-on role, requiring technical expertise in computational chemistry, a strong interest in the application of co-folding, familiarity with the drug discovery process and a proactive drug-hunter mindset. This role is based in our San Diego Headquarters. KEY RESPONSIBILITIES - Apply a range of ligand and structure-based approaches across hit identification, hit to lead and lead optimization phases (e.g. cheminformatics, pharmacophore modeling, docking and shape-based based virtual screening, de novo molecular design, MD simulation) - Guide design cycles through the identification of structure-activity relationships and the integration of computational predictions with bioactivity data - Partner with medicinal chemists to design, evaluate and prioritize virtual libraries, and propose actionable molecular designs - Partner with ML scientists to integrate SBDD methods with our proprietary transformer-based property prediction technology (Enchant) - Leverage and evolve our proprietary protein-ligand co-folding technology (NeuralPLexer) to yield novel and

Associate Director/Director, Technical Operations - Drug Substance (Small Molecules) New York, NY Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, and multiple late-stage development programs addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain's biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X . About This Role: Axsome Therapeutics is seeking an Associate Director/Director, Technical Operations - Drug Substance (Small Molecules) to provide technical leadership across the development and commercial lifecycle of small‑molecule drug substance programs. This role is responsible for supporting and overseeing drug substance manufacturing activities, including technology transfer, process validation, continued process verification (CPV), and post‑approval process changes at internal and external manufacturing sites. The successful candidate will serve as a key technical leader within CMC, partnering closely with external CDMOs and internal cross‑functional teams (QA, QC, Regulatory, R&D, and Supply Chain) to ensure robust, compliant, and efficient manufacturing operations. This position reports into senior

Scientist I, Genotox (Contract) Somerville, Massachusetts, United States Your experience includes… - PhD with 0-2 years of experience in academic or industry setting, MS with 6+ years of experience or BS with 8+ years of experience - Broad knowledge of genome editing technologies and associated off-target discovery assays - Genomic assay development or deployment experience for off-target discovery, verification and structural variation assessment - Familiarity with NGS workflows and library preparation - Deploying PCR-based off-target verification assays such as rhAmpSeq and Hybrid Capture Sequencing - Developing and deploying unidirectional/ligation-mediated PCR assays - Assay related molecular biology techniques including DNA extraction, nucleic acid quality assessment and primer design - Basic cell biology skills including cell line culture and manipulation techniques (electroporation and transfection) - Strong written and verbal communication skills You are interested in… - Developing and deploying assays for genomic safety assessment for the development of Gene Writer candidates - Developing, deploying and analyzing NGS-based assays for off-target discovery and verification - Examining genome structural variants using optical and molecular methods - Working collaboratively with genomic safety, molecular assay, computational biology and regulatory sciences teams to advance Tessera's therapeutic programs - Contributing to scientific report writing, translating complex experimental findings to support regulatory and research goals About you: You are a rigorous, detail-oriented scientist with expertise in genome editing and genomic safety assessment. As a Scientist I on our Genomic Safety team, you will design, develop, and deploy cutting-edge assays to characterize the off-target landscape of our Gene Writer therapeutics

Associate Director, Formulation and Drug Product Development Waltham, MA Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Associate Director, Formulation and Drug Product Development will be accountable for all internal and external activities related to successful formulation development for Dyne's bioconjugate drug products to ensure favorable manufacturability, product quality, and long-term stability. This role will partner closely with colleagues in Research, Pharmaceutical Quality, and Manufacturing to define Dyne's strategy for bringing best-in-class medicines to patients in need, including high-concentration formulations for subcutaneous administration and lyophilized drug products to ensure seamless supply of all drug products for clinical trials. This role is based in Waltham, MA without the possibility of being a remote role. Physical presence onsite is expected on 4-5 days/week. Primary Responsibilities Include: Act as the subject matter expert for drug product development within the Technical Development group, including formulation development, selection of container closure systems, and sterile fill finish clinical manufacturing. Act as

Research Associate II , Molecular Engineering Culver City CA 9522 posted: Posted 4 Days Ago

Associate Director/Director, Biology (Oncology Drug Discovery) San Diego HQ, San Diego, California, United States JOB SUMMARY Iambic Therapeutics is seeking a highly motivated and experienced Associate Director or Director to lead oncology drug discovery efforts and advance our core mission of accelerating small molecule drug discovery through the integration of experimental and AI/ML-driven approaches. The successful candidate will have a proven track record of driving oncology drug discovery programs and will lead project teams with a deep understanding of the progression of drug candidates from hit identification to IND submission. This role will set scientific direction and drive cross-functional collaboration with Chemistry, DMPK, Safety, and Computational teams. This position is based at our San Diego headquarters. IMPACT & SCOPE - Partner with Iambic's computational and ML scientists to incorporate AI/ML-based tools and models that accelerate data interpretation, hypothesis generation, and decision-making across biology workflows. - This is a high-impact role that influences portfolio strategy and progression. KEY RESPONSIBILITIES - Program leadership: Initiate, direct, and execute biology plans that support medicinal chemistry and translational goals across discovery stages (hit-to-lead, LO, candidate selection, IND-enabling). - Cross-functional integration: Chair or co-lead cross-functional workstreams; align assay strategy with SAR hypotheses, DMPK/PD needs, and safety/translational biomarkers. - Collaboration leadership: Lead or co-lead key scientific collaborations with internal and external partners, driving integration of data and strategy toward shared objectives. - Assay strategy & data integrity: Conceptualize and oversee the design and validation of in vitro and ex vivo assays (signaling, binding, trafficking, imaging, and mechanism

Director, Imaging Biomarkers Waltham, MA Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Director of Imaging Biomarkers lead s the development and execution of innovative imaging strategies across Dyne's therapeutic programs. This pivotal role will ensur e that imaging biomarker strategies are scientifically rigorous, clinically relevant, and condu cive to robust therapeutic development. The person in this role focuses on enhancing the understanding of disease mechanisms , patient populations, evaluating therapeutic efficacy, and supporting clinical trial designs through innovative imaging approaches. This role is cri tical to linking early phase research to clinical development, providing essential insights that drive decision making. The person in this role leverages their expertise in various imaging modalities to develop novel biomarker applications that assess therapeutic efficacy, drive patient-centric trial designs, and facilitate regulatory approval processes. This role combines scientific depth with strategic vision, driving the discovery, validation, and application of advanced imaging modalities to enable precision medicine and accelerate

Senior Scientist, Molecular Biology Cambridge, MA Company Summary: Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. The role We are seeking a highly innovative and driven Senior Scientist, Molecular Biology to lead the design and generation of next-generation DNA constructs enabling programmable medicines. This role is ideal for a scientist who thrives at the intersection of synthetic biology, high-throughput cloning, and computational sequence engineering . You will play a critical role in building scalable platforms for plasmid DNA design, construction, and optimization , leveraging automation, algorithm-driven sequence design, and data-centric workflows . The ideal candidate brings deep technical expertise, creative problem-solving, and a passion for pushing the boundaries of nucleic acid engineering in a fast-paced, entrepreneurial environment. The Senior Scientist will report to the Director of Molecular Biology and is expected to manage a direct report. The role involves close collaboration with other Scientists and group leads across the company as part of a highly collaborative and growing R&D

Associate Director R&D AI Solutions & Analytics Princeton, New Jersey, United States; San Diego, California, United States; South San Francisco, California, United States About Acadia Pharmaceuticals Acadia is committed to turning scientific promise into meaningful innovation that makes the difference for underserved neurological and rare disease communities around the world. Our commercial portfolio includes the first and only FDA-approved treatments for Parkinson's disease psychosis and Rett syndrome. We are developing the next wave of therapeutic advancements with a robust and diverse pipeline that includes mid- to late-stage programs in Alzheimer's disease psychosis and Lewy body dementia psychosis, along with earlier-stage programs that address other underserved patient needs. At Acadia, we're here to be their difference. Please note that this position can be based in San Diego, CA, San Francisco, CA, or Princeton, NJ. Acadia's hybrid model requires this role to work in our office three days per week on average. Position Summary The Associate Director, R&D AI Solutions & Analytics will serve as a strategic and technical leader responsible for advancing AI-enabled analytics and digital innovation capabilities across Research & Development (R&D). This role will focus on leading the design, implementation, scaling, and adoption of analytics and AI-driven solutions that improve decision-making, optimize clinical development operations, and enhance portfolio insights across the organization. The individual will partner closely with R&D stakeholders, Digital/IT teams, and external vendors to deliver scalable analytics products, intelligent workflows, AI-enabled solutions, and operational insights capabilities. This role requires a highly collaborative and execution-oriented leader who thrives