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Insitro

11 open roles indexed with location, benefit, and apply-link signals where available.

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  • Senior Manager, Imaging Machine Learning

    South San Francisco, CA

    unspecified Salary not disclosed

    Senior Manager, Imaging Machine Learning South San Francisco, CA The Opportunity insitro's mission is to bring better drugs faster to patients who can benefit most, through machine learning and data at scale. Our discovery strategy integrates insights from multiple phenotypic readouts across diverse high-content data modalities, including data from public and proprietary human cohorts and in vitro cellular systems generated by our proprietary, automated wet-lab platforms. In this role, you will lead and grow a team of exceptional machine learning researchers responsible for co-developing methods for extracting information from in-vitro biology using computer vision and machine learning. You will lead an established team of 5 machine learning scientists, several at the Staff level, and be expected to grow it over time. Your team will partner closely with laboratory scientists to develop biological assays in a tight loop, iterating sample preparation protocols and feature extraction methods in tandem. As the manager of this team, you will be responsible for structuring these collaborations in ways that ensure the success of all teams, and your individual team members, as measured by our ability to drive insitro's therapeutic programs forward through understanding of causal human biology. In addition to working closely with the lab, you and your team will partner closely with our imaging software team, responsible for co-developing and scaling methods your team develops, and computational biologists who will subsequently leverage these tools to extract program-level insights in conjunction with omics (perturb-seq) and clinical insights. As the leader of a team of researchers

  • Chief Medical Officer

    South San Francisco, CA

    unspecified Salary not disclosed

    Chief Medical Officer South San Francisco, CA The Opportunity insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics-whether small molecules, biologics, or oligos. With programs in key therapeutic areas like MASH, ALS, obesity, and dry AMD advancing toward the clinic, and our first IND submission for MASH slated for the second half of this year, we are at a pivotal inflection point. Since its founding in 2018, insitro has raised approximately $800M from capital raises and discovery partnerships with pharmaceutical companies, including Bristol Myers Squibb and Eli Lilly. We are seeking an innovative, highly quantitative, and data-driven Chief Medical Officer (CMO) to architect and lead our end-to-end clinical development strategy. This role is paramount to ensuring we fully leverage our AI/ML capabilities to maximize the probability of clinical success and accelerate timelines. A key success factor in this role will be a proven track record of designing and leading the execution of Phase 1 trials bridging the gap between translational medicine and the clinic and successfully designing and delivering Phase 2 trials, establishing human POC. You will achieve this by leveraging our AI/ML capabilities to architect innovative trial designs that optimize patient selection and dosing from the outset. By imbuing translational thinking into our discovery efforts and working with our discovery teams, you will ensure that the clinical foundations for

  • Scientist II, Arrayed Screening

    South San Francisco, CA

    unspecified Salary not disclosed

    Scientist II, Arrayed Screening South San Francisco, CA The Opportunity The unprecedented convergence of multi-modal data and AI has the potential to revolutionize drug discovery. insitro is harnessing this moment to redefine how medicines are developed for complex diseases. Our success depends on our ability to attract, develop, inspire, and retain amazing, diverse talent and build a collaborative, high-performing, inclusive, and equitable culture. insitro is seeking a highly motivated Scientist II, Arrayed Screening to join our experimental biology and screening organization. In this role, you will help build, optimize, and execute high-throughput arrayed screening workflows that generate high-quality, decision-grade biological datasets for drug discovery. This is a highly collaborative role at the interface of cell biology, assay development, automated screening, disease modeling, and machine learning. You will work closely with biologists, bioengineers, automation scientists, data scientists, machine learning scientists, and drug discovery teams to design and run scalable cell-based and biochemical assays across therapeutic programs. The ideal candidate brings deep hands-on experience in cell-based assay development, high-throughput screening, mammalian cell culture, and quantitative data analysis, and is excited to generate robust biological data that can power ML-driven drug discovery. This role reports to the Director, High Throughput Biology and requires you to be onsite at our South San Francisco office 5 days per week . Responsibilities - Develop, optimize, and execute arrayed screening assays in 96- and 384-well plate formats, including endpoint, kinetic, imaging-based, and/or biochemical readouts. - Design and implement cell-based screening workflows using immortalized, primary, iPSC-derived, or engineered

  • Director, Quality Assurance

    South San Francisco, CA

    unspecified Salary not disclosed

    Director, Quality Assurance South San Francisco, CA The Opportunity At our company, quality isn't a hurdle to innovation-it's the foundation that makes our data-driven insights trustworthy. You will not just be checking boxes; you will be defining the regulatory standards for the future of AI-driven drug discovery. As we transition into clinical-stage operations, we are looking for a Director of Quality Assurance to serve as a key architect of our quality culture. This is a "player-coach" role designed for a leader who can balance rigorous GXP compliance with the agility required in a data-driven, AI-forward company. You will stand up our clinical quality systems, manage global vendors, and partner with our Compute organization to define how the next generation of AI-driven medicine is validated and regulated. Based in South San Francisco, this position reports directly to the Chief Technology Operations Officer and offers an in person hybrid schedule of either three days per week or one full week per month . Responsibilities - Clinical Quality & QMS Leadership - Build the Foundation: Design and implement a robust, phase-appropriate Quality Management System (QMS), including Document Control, Deviations, CAPAs, and Change Control - SOPs & Training: Author core SOPs and develop a streamlined training program that ensures compliance without creating unnecessary friction for the research and operations teams - Phase-Appropriate Strategy: Provide expert guidance on maintaining compliance for early-phase clinical work while building a scalable bridge toward future commercialization - Vendor Oversight: Lead the quality lifecycle for CROs/CMO/CDMOs. Perform audits for partners

  • Senior Director / Vice President, Clinical Operations

    South San Francisco, CA

    unspecified Salary not disclosed

    Senior Director / Vice President, Clinical Operations South San Francisco, CA The Opportunity The unprecedented convergence of multi-modal data, advanced disease modeling, and computational power is revolutionizing drug discovery. insitro is harnessing this moment to redefine how medicines are developed for complex diseases. Our AI/ML-enabled platforms integrate and scale data to rapidly discover novel biological insights to redefine complex diseases and identify new targets and drugs. To enable this vision we are seeking a Senior Director / Vice President of Clinical Operations who will build an AI-forward operations capability. This role will partner with Discovery, Translational Medicine, Technical Operations, Clinical, Regulatory, External R&D, Biostatistics and Procurement teams to directly improve patients' lives by leading clinical trial operations across neurological, ophthalmological and metabolic indications, advancing innovative medicines and diagnostics in a patient-focused way. You will lead the Clinical Operations function at insitro; implementing clinical operations strategies to support the development of multiple therapeutics and diagnostics. Identification of the right patients, enrolling them efficiently, and acquiring robust clinical data to inform decision making remain key challenges for clinical trial operations. You will be at the forefront of designing and implementing innovative, accelerated operations approaches, and you will have the opportunity to utilize insitro's machine learning expertise to achieve operational excellence. You will report directly to the Chief Medical Officer. This role can be either onsite (3 days per week) in our South San Francisco office or hybrid (~1 week per month) in our office. Additional travel may be needed to relevant medical

  • Senior Scientist, Oligonucleotide Therapeutics

    South San Francisco, CA

    unspecified Salary not disclosed

    Senior Scientist, Oligonucleotide Therapeutics South San Francisco, CA The Opportunity At the heart of insitro's strategy is to generate multi-modal phenotypic cellular data in our automated laboratories for our cell machine learning platform and utilize high content human clinical, imaging and genetic data in our clinical machine learning platform to unlock and de-risk novel therapeutic targets for drug discovery. Our drug discovery efforts span from small molecules to oligonucleotides. We are seeking a highly motivated scientist to support our growing efforts in the oligonucleotide drug discovery space. This role will report to the head of our oligonucleotide drug discovery. In this role the candidate will get an opportunity to work across targets and therapeutic areas and will be supporting oligonucleotide drug discovery and tech dev encompassing several modalities such as siRNAs, ASOs and mRNA. The ideal candidate will be working in a highly collaborative environment with our therapeutic area scientists, AI/ML scientists, and chemists, to bring transformative medicines to patients faster. You will be joining a vibrant biotech startup that has long-term stability, with significant funding, and in a high-growth phase, and you will have many opportunities to make a significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro's culture, strategic direction, and outcomes. Join us, and help make a difference to patients! This is an onsite role based in insitro's South San Francisco headquarters, coming onsite 3-4 days a week. Responsibilities - Design and optimize siRNA, antisense

  • (Senior) ML Scientist

    South San Francisco, CA

    unspecified Salary not disclosed

    (Senior) ML Scientist South San Francisco, CA The Opportunity State-of-the-art technologies that measure multiple cellular aspects of in-vitro biology are at the heart of insitro's efforts to accelerate drug development. Computational biology is key to elucidating the relationship between these phenotypes and human disease and translating them into actionable outcomes. We are looking for an expert in ML method development for biological data analysis, in domains such as network analysis, systems biology, graph-based modeling, causal structure learning, single cell omics, or imaging modalities. Your expertise will help the team navigate the complexities of developing disease relevant cell models and analyzing high throughput phenotypic screens, and ensuring that the tools being developed are calibrated and effective, and that analyses are performed to the highest rigor and in line with best practices in the broader scientific community. In this role, you will collaborate closely with experimental biologists, computational biologists, and other machine learning scientists, support the identification of novel phenotypes, the development of new screening paradigms, and advance our understanding of disease. You will develop and utilize diverse machine learning and bioinformatic methods to perform diverse downstream analyses, including integrating with other data modalities, including human cohort data in order to extract insights about disease mechanisms. You will be part of a cross-functional team of life scientists, data scientists, bioengineers, software engineers, and machine learning scientists that strive to identify therapeutic targets and develop drugs of high efficacy and low toxicity. This role will be reporting to the Head of Computational Biology

  • Senior Machine Learning Scientist, Imaging

    South San Francisco, CA

    unspecified Salary not disclosed

    Senior Machine Learning Scientist, Imaging South San Francisco, CA The Opportunity Imaging based phenotyping of in-vitro biology is at the heart of insitro's efforts to accelerate drug development. At insitro, we use machine learning to derive clinically relevant insights from rich datasets generated in-house. As an Imaging ML Scientist, you will develop ML-empowered computer vision pipelines to extract insights about disease mechanisms from multiple microscopy modalities. You will be part of a cross-functional team of life scientists, software engineers, computational biologists, and machine learning scientists that strive to identify therapeutic targets and develop drugs of high efficacy and low toxicity. You will be joining a vibrant biotech startup that is in a high growth phase, with promising multiple pre-clinical drug targets in areas such as ALS and metabolic disease. A lot can change in this exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro's culture, strategic direction, and outcomes. This role will be reporting to the Director of Imaging, Cellular Machine Learning. This is a hybrid position that requires you to be in our South San Francisco headquarters at least three days per week . Join us, and help make a difference to patients! Responsibilities - Partner with experimental and computational biologists to design, troubleshoot, and optimize high-throughput imaging-based experiments and workflows - Identify, understand, develop, and deploy novel computer vision and machine learning methods such as segmentation, feature extraction, and representation

  • Senior Director, Project & Portfolio Management

    South San Francisco, CA

    unspecified Salary not disclosed

    Senior Director, Project & Portfolio Management South San Francisco, CA The Opportunity The unprecedented convergence of multi-modal data, advanced disease modeling, and computational power is revolutionizing drug discovery. insitro is harnessing this moment to redefine how medicines are developed for complex diseases. Our AI/ML-enabled platforms integrate and scale data to rapidly discover novel biological insights to redefine complex diseases and identify new targets and drugs. To enable this vision we are seeking a Senior Director of Project & Portfolio Management (PPM) who will build an AI-forward PPM organization that will partner with Therapeutic Area, Operations, Clinical and Business Development teams to discover and advance a high-value portfolio of exciting drug candidates into the clinic for neurological, ophthalmological and metabolic indications. Reporting into the CSO, you and your staff will partner with project team leaders in developing rightsized project strategies and create successful team environments to foster high performance and rapid advancement. You will develop and execute high quality integrated project plans with clear timelines spanning research, discovery, clinical development, software engineering, and data science/machine learning. As the leader of PPM you will partner with Compute, Operations and Finance colleagues in establishing agentic AI project management, decision and resource allocation tools and methodologies across our portfolio to support critical initiatives. This role will be hybrid, coming onsite to our South San Francisco headquarters with three days per week in the office. About You - BS degree required in a life science field, MS or PhD preferred - Minimum of 15 years

  • (Associate) Director, People Partner

    South San Francisco, CA

    unspecified Salary not disclosed

    (Associate) Director, People Partner South San Francisco, CA The Opportunity The unprecedented convergence of multi-modal data and AI has the potential to revolutionize drug discovery. insitro is harnessing this moment to redefine how medicines are developed for complex diseases. Our success depends on our ability to attract, develop, inspire, and retain amazing, diverse talent and build a collaborative, high-performing, inclusive, and equitable culture. Our (Associate) Director, People Partner will be a key leader in bringing this people vision and strategy to life, aiming to set a new standard for the employee experience in our industry. You will serve as a hands-on business advisor and organizational "fixer," coaching our leaders through complex team dynamics, organizational design, and rapid scaling. In this role, you will report directly to insitro's Chief People Officer and be a key member of their leadership team. The role is based in South San Francisco and is required onsite most days, with flexibility to work remotely up to 2 days a week. Responsibilities Strategic Partnership & Organizational Effectiveness - Workforce Planning & Strategy: Own and execute end-to-end strategic workforce planning to ensure talent pipelines align with aggressive R&D and scaling milestones - Executive Advisory: Advise executives on aligning manager and employee capabilities to mid-to-long-term business needs - Business Integration: Partner with leaders to translate business strategy into people initiatives that accelerate progress - Organizational Design: Support senior management in translating company mission into sustainable organizational strategies, programs, and behaviors - Change Management and L&D: Work to individually lead

  • VP, Bioassays, Cell Models, and Genomic Screening

    South San Francisco, CA

    unspecified Salary not disclosed

    VP, Bioassays, Cell Models, and Genomic Screening South San Francisco, CA The Opportunity At insitro, we're revolutionizing drug development. We fuse cutting-edge machine learning with large-scale biology and modality-independent drug discovery to tackle major bottlenecks in the pipeline. We've built a leading platform and a team of incredibly talented scientists driven to make a real difference. We're looking for an experienced and dynamic leader to be our VP, Bioassays, Cell Models, and Genomic Screening. This is a pivotal role in shaping and executing insitro's CellML platform. You'll lead the charge in developing and integrating cell models that truly mimic human biology, crafting innovative bioassays, and overseeing our cell-based arrayed and pooled optical screening platforms to accelerate both target and drug discovery. You'll be a central figure, collaborating closely with senior management and teams across therapeutic areas, functional genomics, drug discovery, automation, and machine learning. Your mission: ensure our models, assays, and screening efforts precisely meet the demands of our discovery pipeline and platform execution. This is your chance to join a well-funded AI biotech that's already building a robust pipeline of therapeutic candidates. We're still laying the foundation, which means immense opportunities for you to make a significant impact. You'll work alongside brilliant minds in data science, machine learning, biology, automation, and drug development, applying your expertise to shape insitro's culture, strategic direction, and the success of our discovery platforms. You'll report to the Chief Technical Operations Officer at our South San Francisco office, with at least three days a