Scientist I, Immune Evasion

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About this role

Scientist I, Immune Evasion Watertown, Massachusetts, United States The Role Scientist I, Immune Evasion. Advancing Dyno's immune evasion capabilities by developing and executing innovative assay strategies that enable the discovery and clinical readiness of next-generation capsids. Job Type: Full Time, onsite Location: Watertown, MA How You Will Contribute As a Scientist I, you will independently lead and evolve Dyno's high-throughput immune evasion assay platform, driving antibody evasion studies that support CNS and Muscle capsid discovery programs and partnering cross-functionally to shape experimental strategy and address technical gaps. You will also help expand the team's immune evasion capabilities beyond pre-existing antibodies to emerging clinical readiness challenges, including re-dosing, T-cell responses, complement activation, and innate immunity. At Dyno, every role is mission-driven. Whether in science, engineering, operations, or business, each AAViator contributes to solving some of the most complex challenges in genetic medicine. Responsibilities: - Independently execute and support high-throughput immune evasion (IE) assays, including antibody neutralization and total antibody immunoprecipitation (tAb IP) workflows, to ensure uninterrupted support for CNS and Muscle capsid discovery programs. - Own the day-to-day operation, optimization, and troubleshooting of immune evasion assay platforms, iteratively refining workflows and developing new assay formats in response to evolving program needs and emerging data. - Analyze, interpret, and communicate immune evasion screening data to cross-functional stakeholders, helping inform capsid selection and discovery strategy. - Contribute to the expansion of Dyno's immune evasion capabilities beyond antibody neutralization by reviewing literature, proposing experimental approaches, and conducting feasibility studies related to re-dosing, T-cell responses,

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