Senior / Principal Scientist, AI for Protein Engineering
Lila Sciences - San Francisco, CA USA
Posted May 4, 2026
Benefits
- Parental leave
- Not verified
- Non-birth-parent leave
- Not verified
- Family-building benefits
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- Fertility benefits: Not verified
- Adoption assistance: Not verified
- Surrogacy assistance: Not verified
- Mental health support
- Not verified
- Relocation assistance
- Not verified
- Childcare support
- Not verified
- Learning budget
- Not verified
- Verification
- Not verified
- Salary
- $268K-$358K not verified - source not recorded; timestamp not recorded
- 401(k) match
- Not verified
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Market context
- U.S. role benchmark (BLS OEWS)
- $111,944 U.S. median for this role
- Projected growth (BLS Employment Projections)
- +13.7% - Much faster than average
180% above the BLS role benchmark for data and ml aggregate.
Matched to SOC 15-1252 - Data and ML aggregate by role bucket.
Source: U.S. Bureau of Labor Statistics, OEWS, May 2024 and Employment Projections, 2024-2034.
Schedule
- Shift type
- Not verified
- Weekend work
- Not verified
Application
- Cover letter
- Not verified
- Assessment
- Not verified
- Deadline
- Not stated
Where they hire
State eligibility is not yet verified.
About this role
Senior / Principal Scientist, AI for Protein Engineering San Francisco, CA USA Your Impact at LILA Lila is building a platform where AI and automation co-evolve to solve the hardest problems in medicine. Within Life Sciences AI (LSAI), the AI for Protein Engineering team develops and uses the generative and predictive models that drive Lila's biomolecule design programs from in silico hypothesis to wet-lab validated lead. We are seeking a Senior or Principal Scientist to join this team as a senior IC focused on antibody design and engineering. You will develop and execute the methods and workflows that ensure successful completion of antibody campaigns. Scope may expand to additional modalities such as enzymes and peptides as needs evolve. This role sits at the bilingual edge of ML and biology. You will own biological understanding of campaign needs and partner closely with the Life Science Research team to design and validate computational predictions in the lab. You will shape the technical agenda for AI protein engineering at Lila and represent that work both internally and to the broader research community. What You'll Be Building - Develop and own protein design and engineering workflows for antibody campaigns, including de novo design, affinity maturation, and developability optimization - Execute design workflows end-to-end for active campaigns and deliver wet-lab-validated leads against program milestones - Translate campaign requirements - epitope selection, affinity targets, biophysical constraints, and developability criteria - into well-defined ML problems and design specifications - Adapt and extend state-of-the-art AI methods (generative models,
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