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Software Engineer - Core Infrastructure

Genesis Molecular AI - San Mateo, CA

Posted Jan 27, 2026

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About this role

Software Engineer - Core Infrastructure San Mateo, CA Genesis Therapeutics is building a world-class computational team to solve problems in drug discovery through machine learning, biophysical simulation, and computational chemistry. We are looking for an Infrastructure Engineer that is excited to help develop new medicines and play a critical role in building out our AI platform. You Will - Work on our infrastructure team to maintain and grow our multi-cloud compute infrastructure that supports our ML model training, computational chemistry research, and ongoing drug discovery efforts - Build out our configuration and procedures for monitoring, resource allocation, and deployment automation, as we continue to grow our autoscaling compute clusters to handle larger workloads - Work on orchestration scheduling framework to increase our execution throughput, reliability, and compute utilization across heterogeneous pipelines You Are - 5+ years of experience building and maintaining cloud infrastructure at scale, e.g. within AWS or GCP - Proficient with Python, Bash, Terraform, Ray and Kubernetes - Ideally, experience building and maintaining compute clusters running distributed ML training jobs with 1,000+ GPUs - Nice to have: hands-on experience with physical hardware + datacenter management What We Offer - The opportunity to work on high impact infrastructure that is used to accelerate the discovery of new medicines - A world-class, tight-knit team of good-hearted people across software, machine learning, computational chemistry, medicinal chemistry, and biology - Competitive salary and equity. Medical, dental, and vision insurance, and a 401(k) program About Genesis Molecular AI Genesis Molecular AI is pioneering

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