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Director Clinical Pharmacology & DMPK

Alumis - South San Francisco

Posted Jun 4, 2026

Benefits

Parental leave
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Non-birth-parent leave
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Family-building benefits
  • Fertility benefits: Not verified
  • Adoption assistance: Not verified
  • Surrogacy assistance: Not verified
Mental health support
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Relocation assistance
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Childcare support
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Learning budget
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Verification
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Salary
$200K-$240K From the posting source
401(k) match
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Market context

U.S. role benchmark (BLS OEWS)
$81,444 U.S. median for this role
Projected growth (BLS Employment Projections)
+6.9% - Faster than average

170% above the BLS role benchmark for healthcare aggregate.

Matched to SOC 29-1141 - Healthcare aggregate by role bucket.

Source: U.S. Bureau of Labor Statistics, OEWS, May 2024 and Employment Projections, 2024-2034.

Role

Role function
Healthcare From the posting source
Seniority
Staff Plus From the posting source

Schedule

Shift type
Not verified
Weekend work
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Company

Equity
Offered Verified - SEC 10-K source

Application

Cover letter
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Assessment
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Deadline
Not stated

Where they hire

State eligibility is not yet verified.

About this role

Director Clinical Pharmacology & DMPK South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is seeking a Director of Clinical Pharmacology & DMPK to drive clinical pharmacology strategy and PK/PD modeling for our small-molecule programs in immune-mediated diseases. This role partners closely with cross-functional teams and reports to the Head of Clinical Pharmacology & DMPK. Specific responsibilities include but are not limited to: Lead clinical pharmacology strategy, dose selection, and PK/PD and biomarker planning across early and late-stage programs. Conduct and interpret PK, PK/PD, exposure-response, and simulation analyses using tools such as NONMEM, WinNonlin, R, Python, and Simcyp. Integrate translational and nonclinical PK/PD data to support FIH dose projections and DDI assessments. Oversee bioanalytical CROs, ensuring high-quality PK/PD/biomarker data and GLP/GCP compliance. Partner with Clinical Operations on sample management and protocol design. Communicate quantitative findings clearly and contribute to regulatory documents (protocols, IBs, INDs, NDAs, IMPDs). Collaborate across Clinical Development, Biostats/Data Science, Nonclinical, and Program Management. Key Requirements and Qualifications PhD, PharmD, or equivalent in Pharmacokinetics, Pharmacology, or related field. 6 to 8+ years of industry experience in Clinical Pharmacology, DMPK, or Quantitative Pharmacology. Strong expertise in PK, PK/PD, DMPK, and translational sciences. Proficiency with modeling/simulation platforms (NONMEM, WinNonlin, Simcyp, R, Python). Excellent communication, organization, and ability

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