Iovance Biotherapeutics Inc jobs

Clinical Trial Manager Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Clinical Trial Manager has operations experience within the biotech/biopharma arena. This individual has a high level of core competencies and technical skills to be applied within the management of clinical programs leading to registrational submissions of Biologic License Applications (BLAs). The Clinical Trial Manager position is an opportunity for an individual to join a cross-functional clinical team having high-visible and dynamic input in a therapeutic indication of unmet medical need and orphan disease status. Essential Functions and Responsibilities - Support the overall operational execution of clinical studies on one or more clinical programs from initial study synopsis through final project deliverables (ie, database hard-lock, final TLFs, CSR, etc.) - Manage the implementation, on-time execution and conduct of clinical studies; including the development of budget items, milestones and timelines, in addition to scope and management of resources (including vendor selection). All leading to overall quality, safety, and compliance throughout the duration of the clinical studies and program. - Oversight

AI Strategy Associate Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview Iovance Biotherapeutics is a commercial-stage cell therapy company focused on developing life-saving cancer immunotherapies. We are building an internal AI Strategy & Operations function to drive measurable cost savings and operational efficiency across the entire organization. We are looking for an AI Strategy Associate to drive process discovery and optimization across Iovance. This role is the analytical engine of our AI program. You will run a comprehensive diagnostic across 15 business functions, build the financial models that translate use cases into P&L savings commitments, and manage stakeholder relationships across the company. Think of this as the operating-side equivalent of a top-tier consulting engagement. You will interview stakeholders, map pain points to savings levers, build controlled comparisons to prove AI impact, and deliver a financial model the CFO can underwrite. In this role, you will own the outcomes, not just the recommendation. Unlike traditional analyst roles, the successful applicant is required to be adept at using AI tools, be able

AI Product Engineer Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview Iovance Biotherapeutics is a commercial-stage cell therapy company focused on developing life-saving cancer immunotherapies. We are building an internal AI Strategy & Operations function to drive measurable cost savings and operational efficiency across every department in the company. We are hiring an AI Full-Stack Product Engineer to build the first generation of internal AI-enabled tools at Iovance. This is a hands-on full-stack JavaScript engineering role for someone who uses AI-assisted development to ship faster without compromising code quality, security, or maintainability. You will design, build, and deploy micro-applications and workflow automations that solve real business problems. You will work directly with stakeholders across Commercial, Regulatory, Quality, Manufacturing, and R&D to turn validated use cases into tools people use every day. The foundation of this role is engineering. The multiplier is AI fluency. You should be using tools like Claude, Cursor, Copilot to dramatically accelerate your workflow. We want a skilled engineer who produces significantly more output because of how

Associate Medical Director Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Associate Medical Director is primarily responsible for physician-supported clinical trial support and overseeing the direction, planning, execution, and interpretation of IOVANCE clinical trials. Essential Functions and Responsibilities - Primary point of clinical contact for IOVANCE clinical trials. Directs protocol implementation including site identification and communication with Clinical Operations, attendance at investigators' meetings (virtual and live), correspondence with sites regarding patient eligibility and safety considerations, and interaction with US- and Global Medical Affairs teams - Co-manages program development and reports directly to Executive Medical Director. Responsible for cross-functional collaboration with all of the disciplines necessary for successful drug/therapy development (Study Management Team level): clinical, manufacturing, quality assurance, regulatory, medical affairs, legal, biostatistics, global patient safety, data management, pharmacovigilance, and clinical operations - Monitors clinical trials including the oversight of all aspects of trial conduct and safety, contact with investigators and site study staff, and CRO medical monitors - Supports data analysis and assembly, including IDMC meetings, interim analyses, IB

Senior Accountant Philadelphia, PA Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Senior Accountant, reporting to the Senior Director, Finance Plant Controller, is responsible for the maintenance, execution of day-to-day general accounting activities, and oversight of Iovance manufacturing site's (iCTC) monthly, quarterly and annual financial reporting and close process, including analysis and reconciliation of certain General Ledger accounts; these accounts will include Accrued Expenses and Capital Assets, as well as possibly supporting activities in certain Inventory accounts. These roles and responsibilities include frequent engagement with other Business Partners, external vendors and parties to understand the business and operations. The Senior Accountant will also be responsible for SOX controls execution and documentation, performing various financial analysis, assist with the external audit, special projects and process improvement initiatives, and prepare and review certain schedules and information. Specific Responsibilities - Ensure that iCTC GL transactions are accounted for in accordance with U.S. GAAP - Prepare and book journal entries for month-end close, including sub-ledger/ schedule to ledger reconciliations and analysis of reconciling items

Senior Clinical Trial Manager, Research Alliances Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Senior Clinical Trial Manager (CTM) in the Research Alliances team will independently lead and is accountable for the planning, execution, management, and reporting of clinical projects supporting Iovance commercial activities, including Expanded Access Programs (intermediate EAP, single-patient and Ex-US Access Programs) and Phase 4 post marketing studies. In addition, the Sr. CTM/CTM will provide operational leadership for studies within a growing portfolio of Investigator Sponsored collaborations and other non-clinical collaborative research initiatives involving lifileucel and Proleukin. This position works very closely with external vendors, HCPs, as well as multiple Iovance teams: Commercial, Medical Affairs, Regulatory, Safety, Clinical, Biometrics, Quality, Legal, Quality, Supply Chain & Logistics and Manufacturing. The ideal candidate will have clinical operations experience within the pharma/biotech arena, be self-motivated, and able demonstrate the ability to manage complex programs independently while collaborating effectively in a dynamic, agile, and evolving organization. Essential Functions and Responsibilities - Oversee the timely activation, execution, and management of Expanded

Manager, Regulatory Affairs CMC Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Manager, Regulatory Affairs CMC, represents Regulatory Affairs on cross-functional teams, working closely with other team members to support corporate and departmental objectives. An important aspect of this role is the planning and management of submissions. Attention to detail in written correspondence, in the maintenance of regulatory files, and ability to work with diverse internal and external stakeholders are also important factors for success in this role. Essential Functions and Responsibilities - Manages the planning, compilation, QC, and submission of Investigational Drug Applications (INDs), Biologics License Applications (BLAs), and their amendments. - Prepares routine IND and CTA amendments. - Work with submission authors and reviewers to ensure that source document planning is complete and that high-quality documents are approved on-schedule. - Represents Regulatory Affairs and provides regulatory expertise to cross-functional teams on specified projects and topics. - Interface with Quality Assurance, clinical manufacturing, commercial manufacturing and other stakeholders to further develop and maintain a robust change control program.

General Ledger Accountant I [Contract to Hire] San Carlos, CA Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The General Ledger Accountant I is responsible for the maintenance and reconciliation of assigned General Ledger accounts, including prepaids, accruals, and other short- and long-term assets. This role supports the monthly close process, prepares balance sheet reconciliations, and maintains strong internal controls in accordance with U.S. GAAP. The General Ledger Accountant I also serves as the system administrator for the Concur Employee Expense Reporting application and manages the corporate credit card program, including user administration, system modifications, and coordination with Concur auditors. Specific Responsibilities - Ensure all General Ledger (GL) transactions are recorded in accordance with U.S. GAAP. - Process journal entries for month-end close, including subledger-to-ledger reconciliations. - Create accounting schedules and analyses to review additions and deletions, depreciation/amortization, and department expenditures. - Perform monthly bank reconciliations and resolve discrepancies in a timely manner. - Perform balance sheet reconciliations for assigned accounts, including prepaids, accruals, and other short- and long-term assets. -

Senior Clinical Scientist [Contract] San Carlos, CA Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Senior Clinical Scientist participates in support of the Clinical Development plans (CDPs) and supports the assigned Medical Director/Clinical Science Physician(s) with various deliverables necessary for effective and efficient CS plan execution for the assigned assets/indication(s). The Senior Clinical Scientist has primary responsibilities for supporting Medical Directors/Clinical Science Physicians with clinical documentation, representing Clinical Science on various teams/sub-teams or other appropriate forums, and supporting training of study site and/or CRO personnel. The Senior Clinical Scientist is expected to perform their responsibilities with independence and are likely to have external interactions with cooperative groups, key opinion leaders (KOLs), and external vendors supporting the work of Clinical Science. Specific Responsibilities - Supports the design and writing of clinical protocols and associated clinical study documents (e.g., ICFs, charters, operational manuals, etc.) - Serves as an expert on the clinical study design (including trial procedures and requirements) and develops training materials to ensure quality execution by the investigational sites. -

Quality Control Specialist I, Sample Management [Contract to Hire] Phildelphia Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Quality Control Specialist I, Sample Management will ensure time-sensitive distribution of quality control samples in support of QC-related activities. They will be responsible for sample inventory management as well as internal and external sample distribution, including storage and shipping under appropriate conditions, for all the iCTC cell therapy asset. Essential Functions and Responsibilities: - Maintain raw material, in-process, and final product samples, including inventory tracking and reconciliation. - Ensures timely sample distribution in support of Quality Control activities, including internal distribution and external shipping. - Ensures proper storage of sample inventory and proper shipping conditions - Support sample receipt and documentation. - Maintain current knowledge base of regulations, corporate policies, and industry best practices, trends, and standards to ensure that the function remains in compliance with applicable requirements. - Packaging of samples using temperature controlled dewars, cold packs, and dry ice. - Perform Quality Control activities - Performs peer review of logbooks

Director, HTA, Evidence, and Global Access Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview As Iovance prepares to bring AMTAGVI® to patients globally outside the United States, we are seeking an individual who is experienced with HTA, Evidence, and Global Access. This role will be a critical contributor to Iovance's HTA, evidence, and global access strategies and will report to the Senior Director, Global Market Access. The position is responsible for supporting international markets where Iovance is pursuing reimbursement, planning for new indication and products, and support of commercial activities generally. Core responsibilities include end-to-end management of health technology assessment (HTA) submissions, developing Iovance's evidence generation activities, engagement with HTA bodies and payers, development of global value and access materials, and project management across global market access and HEOR activities. The role will also support HEOR-related activities -including research, economic modeling, and publications - and may from time to time engage in activities supporting projects from regulatory, commercial, or other teams. The Director will serve as the internal subject matter

Senior Regulatory Affairs CMC Associate Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview Iovance seeks a highly motivated Senior Regulatory Affairs Specialist. The successful candidate has experience planning and managing regulatory authority submissions. He / She will coordinate CMC submissions across multiple products, supporting management of the planning, compilation, QC, and submission of CMC dossier content to clinical and commercial applications, and their amendments. This role will be responsible for the preparation and adaptation of submission documents for use in global clinical and commercial submissions following eCTD specifications and market specific requirements and may be responsible for independently planning and preparing routine clinical trial application related amendments and commercial submissions (e.g. Annual reports, DSUR, health authority queries). An important aspect of this role is the planning and management of submissions. Attention to detail in written correspondence, in the maintenance of regulatory files, and ability to work with diverse internal and external stakeholders are also important factors for success in this role. Another important aspect of this role is the capacity

Cell Therapy Account Management - Michigan Michigan Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview Amtagvi™ is the best-in-class cell therapy treatment for advanced melanoma. The Cell Therapy Account Management (CTAM) will be responsible for driving Amtagvi demand by building a robust referral network between community practices and academic centers; enable early patient identification and streamline referral pathways; and collaborate with internal teams to enhance scientific and operational excellence in cell therapy account management. To succeed in this role, you will use prior experience to optimize territory strategy in the oncology rare disease space and have demonstrated experience influencing others and building relationships. Additional competencies include experience with immunotherapy and solid tumor cancer, as well as prior launch experience, demonstrated ability to drive demand, pull through, and sustain the growth of Amtagvi™. Essential Functions and Responsibilities: - Drive Amtagvi TM demand and appropriate pull-through at targeted ATCs and serve as a liaison between community oncology practices and internal stakeholders to align initiatives with business and medical objectives. - Serve as the

Accounts Payable Specialist [Contract to Hire] Hybrid Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Accounts Payable 'AP' Specialist is a frontline accounting position, reporting directly to the Accounts Payable Manager. The AP Specialist is responsible for processing invoices and payments received from vendors and suppliers. This involves reviewing invoices for accuracy and completeness, ensuring they are correctly coded and approved, and entering data into the accounting system. Essential Functions and Responsibilities - Perform day-to-day administration of all payment cycle activities and provide efficient client service. - Manage full AP cycle for assigned vendors, including the related coordination with business process owners. - Ensures correct sorting, general ledger coding, and matching invoices/receipts, where applicable. - Verify that transactions comply with financial policies and procedures established by the Company. - Ensure the Company's authorization matrix approves invoices before payment. - Collaborate with the Procurement team and assist with vendor purchase order inquiries. - Research and resolve invoice discrepancies and issues. - Correspond with vendors and respond to inquiries. - Must adhere

Supervisor, Aseptic Manufacturing - Night Shift Philadelphia, PA Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Supervisor for Aseptic Manufacturing oversees the production process to ensure that all materials are produced safely and follow the company's standards. This position requires timely document review and ensuring all targets are met. In addition, the supervisor will be responsible for developing staff and implementing an effective "First-time right" program to meet Iovance's growing demands. The successful candidate will also help onboard new team members and manage deviations and CAPAs for the training and learning team. It is crucial that the supervisor has innovative technical knowledge and contributes significantly to the overall manufacturing operation. As a leadership team member for autologous cell therapy manufacturing operations, a background in cell culture and manufacturing in ISO class 5 cleanrooms is necessary. Essential Functions and Responsibilities • Supervision and Development direct reports (operators), mentoring/coaching to motivate and mentor peers/ staff to foster a culture of continuous improvement and operational excellence. • Schedule and coordinate day-to-day activities, ensuring

Principal AI Systems Engineer Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview This is a senior role responsible for the hands-on design, build, validation, and deployment of Artificial Intelligence (AI) systems at Iovance Biotherapeutics. This role is focused on execution - turning approved use cases into working, validated, production AI systems that deliver measurable business value. This role directly supports Iovance's strategy to improve overall operational productivity. The ideal candidate is a deeply technical, hands-on senior engineer with demonstrated production experience designing and shipping Large Language Model (LLM) applications, Retrieval-Augmented Generation (RAG) systems, and modern AI integrations. This position works closely with IT leads, business process owners across Manufacturing, Quality, Regulatory Affairs, Clinical, Commercial, G&A, IT Security, Privacy, and Quality Assurance to deliver AI capabilities that respect Iovance's regulated environment. This role executes against a roadmap and prioritized backlog, while contributing technical input to refinement, scoping, and sequencing. Primary Responsibilities - Design, build, and ship AI systems against the approved Iovance AI roadmap, including end-to-end ownership of architecture, retrieval pipelines,

Cell Therapy Account Management - Western PA/WV Pennsylvania Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview Amtagvi™ is the best-in-class cell therapy treatment for advanced melanoma. The Cell Therapy Account Management (CTAM) will be responsible for driving Amtagvi demand by building a robust referral network between community practices and academic centers; enable early patient identification and streamline referral pathways; and collaborate with internal teams to enhance scientific and operational excellence in cell therapy account management. To succeed in this role, you will use prior experience to optimize territory strategy in the oncology rare disease space and have demonstrated experience influencing others and building relationships. Additional competencies include experience with immunotherapy and solid tumor cancer, as well as prior launch experience, demonstrated ability to drive demand, pull through, and sustain the growth of Amtagvi™. Essential Functions and Responsibilities: - Drive Amtagvi TM demand and appropriate pull-through at targeted ATCs and serve as a liaison between community oncology practices and internal stakeholders to align initiatives with business and medical objectives. - Serve as

Aseptic Manufacturing Technician I - Day Shift B [Contract to Hire] Philadelphia, PA Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Rotation Schedule: Week 1: Shift B: Thursday to Saturday from 0700 to 1930 Week 2 Shift B: Wednesday to Saturday from 0700 to 1830 Overview Iovance Biotherapeutics is an immuno-oncology company focused on the development and commercialization of novel cancer immunotherapies based on tumor infiltrating lymphocytes (TIL). The Aseptic Manufacturing Technician I, role is crucial for the autologous cell therapy manufacturing program. This position requires a broad understanding of theories, techniques, and principles to support manufacturing processes. As an Aseptic Manufacturing Technician I, you will primarily be responsible for the following tasks: suite preparation for cell processing, material transfer, environmental monitoring, BSC runner duties, final product inspection, and final product cryopreservation in controlled rate freezers, for commercial and clinical use. This position works across different shifts. Depending on your assigned shift, you may be required to work overtime, weekends, and holidays to ensure the manufacturing process is completed. As this person

Regulatory Affairs CMC Associate II Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview Iovance seeks a highly motivated Regulatory Affairs CMC Associate II. The successful candidate has experience planning and managing regulatory authority submissions. This role will coordinate CMC submissions across multiple products, supporting management of the planning, compilation, QC, and submission of CMC dossier content to clinical and commercial applications, and their amendments. This role will be responsible for the preparation and adaptation of submission documents for use in global clinical and commercial submissions following eCTD specifications and market specific requirements and may be responsible for independently planning and preparing routine clinical trial application related amendments and commercial submissions (e.g. Annual reports, DSUR, health authority queries). An important aspect of this role is the planning and management of submissions. Attention to detail in written correspondence, in the maintenance of regulatory files, and ability to work with diverse internal and external stakeholders are also important factors for success in this role. Another important aspect of this role is the capacity

Cell Therapy Account Management - North Central North Central Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview Amtagvi™ is the best-in-class cell therapy treatment for advanced melanoma. The Cell Therapy Account Management (CTAM) will be responsible for driving Amtagvi demand by building a robust referral network between community practices and academic centers; enable early patient identification and streamline referral pathways; and collaborate with internal teams to enhance scientific and operational excellence in cell therapy account management. To succeed in this role, you will use prior experience to optimize territory strategy in the oncology rare disease space and have demonstrated experience influencing others and building relationships. Additional competencies include experience with immunotherapy and solid tumor cancer, as well as prior launch experience, demonstrated ability to drive demand, pull through, and sustain the growth of Amtagvi™. Essential Functions and Responsibilities: - Drive Amtagvi TM demand and appropriate pull-through at targeted ATCs and serve as a liaison between community oncology practices and internal stakeholders to align initiatives with business and medical objectives. - Serve

Senior Director, Total Rewards and Operations San Carlos, California Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview Iovance is seeking a Sr. Director, Total Rewards and Operations for leading the global total rewards and HR operations function. Reporting directly to the Executive Vice President of Human Resources (EVP HR), will be responsible for innovating, developing, directing and administering Iovance's total rewards programs encompassing all compensation and benefits programs Ensures our rewards philosophy is competitive, equitable, compliant, and aligned with the company's business strategy, mission, and values, supporting talent attraction and retention globally. Overseeing HRIS and HR Operations administration, driving all HRIS initiatives and with deep collaboration with HR business partners the focus of this position is to optimize and execute the delivery of total rewards programs and services to the business. Essential Functions and Responsibilities - As subject matter expert propose, design and implement industry best practices and lead effective, competitive, compliant and fair total rewards programs. - Ensure all compensation and benefits programs comply with global regulatory requirements (e.g., FLSA,

Associate Director, Clinical Business Operations Management Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Essential Functions and Responsibilities - Supports the identification and prioritization of deliverables across clinical departments (i.e., Medical Writing, Biostatistics, Drug Safety, Clinical Science)., organizes cross-functional teams and tracks progress against goals and timelines - Understands and advises on functional priorities within the context of enabling larger organizational success. - Supports business planning, such as budget review, resource forecasting, goals review, etc. - Supports business data collection and analysis, helps track delivery against corporate and department goals and collaborates with Department Heads on Quarterly Business Reviews - Problem solves by leveraging understanding of business and functional relationships to activate right people and solutions. - Spends time connecting individuals and teams within function, across functions and across the organization. - Serves as a thought partner for vision and goal setting and partner with teams to drive functional short-to-long-term business planning and execution. - Keeps Department meetings on track with focused agendas and objectives. Takes minutes and tracks deliverables as

Quality Assurance Specialist I, Document Control and Training [Contract to Hire] Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview This position is responsible for supporting the Quality Document Control and Training program and ensuring compliance to quality objectives and regulatory requirements. Essential Functions and Responsibilities - Independently manage and monitor the processing, review, approval, archival, and distribution of revision- controlled documents in the Electronic Document Management System (eDMS). - Provide user support and guidance on document workflows, processes, and system usage. - Ensure documents meet formatting, content, and compliance standards prior to approval. - Maintain document records to ensure accuracy, completeness, and traceability within the system. - Coordinate document periodic reviews of controlled documents to ensure ongoing accuracy and compliance. - Support internal and external inspections by retrieving documentation and ensuring inspection readiness. - Independently manage training assignments and task execution within the Electronic Document Management System (eDMS). - Generate and distribute training compliance reports for management and audit purposes. - Support onboarding training activities and assignment of required curriculum.

Director, Medical Affairs (Medical Science Liaison) - Mid-Atlantic Remote Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview The Director, Medical Affairs (Medical Science Liaison) is a field-based medical leader responsible for shaping and executing regional field medical strategy for Iovances developmental and marketed products through high-impact scientific exchange, generation and communication of actionable medical insights, and cross-functional partnership. This role develops and sustains relationships with regional and national external experts (e.g., key opinion leaders, investigators, and healthcare systems) and leads territory planning and prioritization to support medical objectives, including clinical trial site identification and execution, consistent with applicable laws, regulations, and company policies. The Director operates with a high degree of autonomy and accountability, provides strategic thought leadership within the field medical organization, and helps establish consistent standards, processes, and capability building across the team, including coaching and mentoring as assigned. Essential Functions and Responsibilities - Own and advance the regional field medical strategy within the assigned territory, ensuring impactful, fair-balanced, evidence-based scientific exchange and representing Iovance as a credible, trusted