Alumis jobs

Senior Scientist, Drug Product Development South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. We are seeking an experienced and highly motivated Senior Scientist for the Drug Product Development group who can work in a collaborative and dynamic environment. The scientist in this role is responsible for activities critical to the development of Alumis' molecules including generation of pre-formulation packages, formulation selection, and manufacturing process development. This primary focus of this role will currently be on solid oral dosage form development but may involve the development of other dosage forms in the future. Responsibilities Hands-on pre-clinical formulation development includes identifying vehicles, excipients, and/or new technologies for poorly water-soluble compounds in support of preclinical PKPD, efficacy, and tox studies. Execute and/or oversee pre-formulation activities including characterization of physicochemical and solid-state properties for investigational small molecules with hands-on instrumental analysis (HPLC/UPLC, DSC, XRPD) and method development. Work effectively with external CDMOs to develop early-stage drug products and oversee production of clinical trial material in support of clinical timelines. Experience in formulation development, process optimization for small molecule solid oral dosage forms including modified-release products includes execute/oversee formulation and manufacturing process development activities. Excellent oral and writing communication skills and flexibility to work in a fast-paced team environment by providing updates

Vice President Corporate Communications & Investor Relations South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Position Purpose The VP of Corporate Communications and Investor Relations will lead the development and implementation of Alumis' strategic communications initiatives to build identity, reputation and visibility across multiple stakeholders, including media, patient advocacy, potential customers and employees. Reporting to the Chief Finance Officer, the position will work closely with Alumis' executive and senior leadership, investor relations and other key stakeholders. Job Description and Key Responsibilities The Communications position will play a key role generating the internal and external communications strategy for our portfolio of assets and corporate messages to ensure the company's evolving story is communicated effectively. This position will work across functional areas including corporate communications/ PR, commercial, investor relations, clinical, medical affairs, research and HR. They will be the point person for generating, reviewing and deploying communication initiative across various mediums (with subject matter expertise assistance) and responsible for consistently communicating across multiple channels and platforms, including media and scientific conferences. Specific responsibilities include but are not limited to: Develop communications strategies and plans that effectively communicate corporate and product stories to external audiences; generate awareness and a positive external response to the company's vision and corporate objectives Provide

Senior Scientist I Analytical Development South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. The small molecule CMC team is seeking highly motivated Sr. Scientist I of Analytical Dev e lopment to help build our dynamic small molecule CMC group at Alumis . The successful candidate will help to support the analytical development and quality control activities from the preclinical phase through late-stage clinical development. Having analytical development expertise and experience in working with CMOs/CTLs, coupled with thorough understanding of the associated quality and regulatory awareness are key assets. RESPONSIBILITIES Support development, validation , and transfer of analytical methods to support starting material, intermediate, drug substance and drug product testing at CMOs/CTLs Execute and/or support the in-house method development activities using UPLC/HPLC, LC-MS, KF, and dissolution instrumentation and technique s for Phase 1 to late-stage drug development Review CMO/CTL analytical data (in-process, release, and stability data), protocols and reports Trend stability and release data using statistical methods Assist in investigation for various non-conformance events at CMOs/CTLs Collaborate with CMC team, QA and CMOs /CTLs towards timely generation and approval of documents Communicate scientific results (oral and written) in a clear and concise manner within cross-functional teams Author technical reports and documents in support of regulatory filing Assist in

Senior Director, Medical Strategy and Operations United States Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. This role will serve as a strategic and operational partner to the Vice President of Medical Affairs and Medical leadership team, and is responsible for ensuring that medical capabilities, processes, systems, and execution models are efficient, compliant, scalable, and aligned with Alumis' growth strategy. The Senior Director, Medical Strategy and Operations, will be responsible for advancing key initiatives aimed at optimizing and showcasing the impact of the Medical Affairs team. This is a hands-on position that includes driving medical strategic initiatives, enhancing the Medical Affairs systems, supporting critical medical insights processes, and developing innovative solutions to measure and report on medical affairs performance and impact. The role demands an individual who combines scientific knowledge with strong operational leadership to thrive in a fast-paced, agile environment to elevate our medical affairs capabilities. Key Responsibilities: · Strategic Leadership: Lead and drive the development and execution of initiatives that elevate the strategic and operational effectiveness of the Medical Affairs team in a consistent and scalable manner. · Medical Affairs Systems Optimization: o Oversee the design, implementation, and optimization of our Medical Affairs systems to improve internal efficiencies, engagement and communications with key opinion leaders (KOLs), healthcare providers,

Senior Director, Trade Operations South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is seeking a highly strategic and execution-oriented Senior Director, Trade Operations to lead the vision, design, and implementation of U.S. trade and distribution models across its dermatology and immunology portfolio. This individual will play a critical leadership role in shaping how products reach patients and providers through agile, efficient, and scalable access pathways. Reporting to the SVP, Market Access, this role will operate as a core member of a lean, high-impact commercialization team. The ideal candidate thrives in a nimble environment, brings a pragmatic and innovative mindset, and is comfortable building strategy from the ground up while remaining deeply involved in execution. Key Responsibilities: Trade & Distribution Strategy Development Lead the design and execution of U.S. trade and distribution strategies, with a focus on specialty pharmacy and specialty distribution channels. Develop nimble, fit-for-purpose distribution models tailored to dermatology and immunology markets, enabling rapid adaptation to evolving payer and patient dynamics. Define channel strategy, including specialty pharmacy network design, limited distribution approaches, and wholesaler partnerships where appropriate. Partner with the SVP of Market Access and other commercialization leaders at Alumis to assess and implement new concepts for channel strategy. Strategic Execution & Launch Readiness Translate

Vice President, Medical Affairs South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. We have recently completed our pivotal trials of envudeucitinib, our second-generation tyk2 inhibitor in moderate to severe plaque psoriasis and expect results from a potentially pivotal Phase 2b trial in SLE in the third quarter of 2026. As a key member of the Alumis team, you will provide overall leadership for the Medical Affairs function, overseeing Medical Affairs, Field Medical Liaisons, and publications. The position will liaise closely with the clinicians responsible for carrying out Alumis' clinical studies as well as our commercial group. Applicants should be a “leader/doer” capable of generating strategies and leading cross functionally. This VP, Medical Affairs will report directly to the Chief Medical Officer. Responsibilities Lead the Medical Affairs function at Alumis Develop and implement key Medical Affairs strategies and activities to support the development of our lead assets Continue to build and scale the Medical Affairs organization Develop and present Medical Affairs operational plans to Development and Executive management Represent company externally Direct and oversee all aspects of Medical Affairs and pre-launch needs Lead medical launch preparations for our lead Psoriasis candidate, ensuring the scientific narrative is robust and well-vetted. As a member of the Development Leadership Team, run

Senior Manager Regulatory Affairs (contract) South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. We are seeking an exceptionally motivated individual to provide leadership and support to global regulatory activities to achieve Alumis' strategic vision in obtaining worldwide approvals to market our products. The individual will represent Regulatory Affairs and work closely with cross-functional study teams and technical regulatory service providers in accordance with health authority and ICH requirements. In addition to being a key member of our project teams, she/he will provide organizational support as the company and its product development pipeline grow. This role will be reporting to the Director of Regulatory Strategy. ESSENTIAL DUTIES & RESPONSIBILITIES · Serve as the Regulatory Affairs representative for Phase 1 to Phase3 trials, ensuring regulatory activities are evaluated, prioritized and executed to meet global regulatory requirements. · Serve as the Regulatory Affairs representative on assigned study teams and assure the progress of studies by addressing regulatory related queries in support of regulatory approvals. · Lead preparation, review and submission of INDs/CTAs, amendments, review and approval of investigator document packages and manage other regulatory activities of the assigned studies as needed. · Establish and meet timelines for regulatory submissions related to INDs/CTAs, including nonclinical, clinical, and CMC activities, while planning

Senior Director, Market Access South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is seeking a high-impact Senior Director to help shape and deliver U.S. market access strategy for a late-stage immunology asset in dermatology. Reporting to the SVP of Market Access, this role is designed for someone who thrives in a lean environment, takes ownership beyond their title, and drives strategy through execution. You will operate as a critical member of a small, senior team, expected to deliver outsized impact without the infrastructure of a large organization. This role is best suited for individuals who have succeeded in complex dermatology markets and are motivated to assess issues, identify feasible solutions, make decisions, and operate with efficiency. Key Responsibilities: Strategic Leadership in a Lean Environment Partner directly with the SVP of Market Access to shape and refine U.S. access strategy. Own and drive high-priority components of pricing, payer positioning, and access execution-personally and with limited support. Challenge conventional approaches and bring forward differentiated strategies grounded in real-world payer behavior. Payer Strategy & Market Impact Lead core elements of U.S. payer strategy, including positioning, coverage objectives, and contracting approach in highly managed, rebate-driven markets. Anticipate aggressive payer tactics (step edits, exclusions, reauthorization criteria) and design pragmatic, executable solutions

Senior/Executive Medical Director, Clinical Development (New Indications) South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Position Summary Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies evaluating envudeucitinib and A-005 across new indications identified for expansion of the Alumis pipeline. This high-impact role will be instrumental in shaping the company's clinical development portfolio, from indication selection through proof-of-concept studies, and will serve as a key scientific leader interfacing with internal teams, regulatory authorities, and the external medical community. --- Key Responsibilities Clinical Development Strategy & Leadership · Lead the design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 and additional pipeline molecules in new therapeutic indications · Develop and refine clinical development plans, including study synopses, protocols, and integrated development strategies for new indications · Provide clinical and scientific leadership to cross-functional study teams, ensuring alignment on

Director, Clinical Quality Assurance - Contractor South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is hiring a Clinical Quality Assurance Director, (CONTRACTOR) reporting to the Executive Director, GCPQA. The role works closely with the Quality leadership and Study Execution Team members to provide ICH-GCP/GVP support for all ongoing clinical studies. This involves working closely with Clinical Operations, Clinical Development, Clinical Supply Chain, Data Management, Pharmacovigilance, Medical Affairs, Regulatory, Legal, and other teams across Alumis. The Clinical QA Director is responsible to ensure quality is embedded throughout the lifecycle of all the ongoing clinical programs through oversight, assessment and monitoring, risk assessment tools, auditing and risk mitigations. The Director will assist with establishing Key Performance Indicators and Metrics to trend and track on the health of the clinical trials. The role is responsible for providing the operational quality guidance for the development teams and supporting the Executive Director of GCP Quality in building the Alumis Quality organization strategy and vision. This position requires expertise in Good Clinical and Pharmacovigilance Practices (ICH-GCP & GVP) and relevant US and EU regulations. The successful candidate will drive, promote, and embed a culture of ethics, integrity, and proactive quality management. The candidate will provide guidance and leadership to ensure that the

Senior Medical Director, Rheumatology South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. We are seeking an experienced Senior Medical Director in Clinical Development who will be involved across the full scope of rheumatology and autoimmune clinical drug development activities from discovery research through first in human, POC, and Phase 3 studies. The role will include leadership of one or more studies within the portfolio and will work closely with all members of the cross-functional asset team, to apply full clinical knowledge to successfully advance clinical programs as well as the overall asset strategy. Principal Responsibilities Serve as the physician lead for LUMUS, a 388-patient Phase 2b clinical trial designed to evaluate the efficacy, safety, and pharmacokinetics of multiple doses of ESK-001 in adult patients with moderately to severely active, autoantibody-positive SLE. Provide leadership of in-stream data reviews and reconciliation efforts. Hold authorship of clinical portions of key study documents, such as Protocol Amendments and Regulatory Submissions. Provide oversight of the LUMUS medical monitor. • Participates in external scientific engagement, including peer-to-peer interactions with MDs. Broadly represent the interests of Alumis as a leader, supporting corporate initiatives across rheumatology. Coach, manage, inspire, and support team members to achieve goals by leveraging a focused and collaborative mindset. Maintain the

Director, Thought Leader Liaison, US Psoriasis Launch South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is seeking an experienced Director of Thought Leader Liaison (TLL) with deep expertise in Dermatology. This role is a field-based commercial leadership role responsible for leading a team of field based TLLs, to develop and execute Key Opinion Leader (KOL) engagement strategies for the US launch of envudeucitinib for Psoriasis. The successful candidate will be a key member of the brand marketing team, working across multiple stakeholders at the intersection of marketing, medical, and field execution, with accountability for team leadership, KOL strategy and execution, and strategic insight generation to shape brand strategy. This role will require a deep understanding of medical science, excellent leadership capabilities, and a strong ability to drive the success of cross-functional teams. Key Responsibilities: Leadership & Team Management Build, lead and manage a team of TLL reports with the responsibility for coaching, developing, assessing performance, delegation, prioritization and

Director Clinical Pharmacology & DMPK South San Francisco Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is seeking a Director of Clinical Pharmacology & DMPK to drive clinical pharmacology strategy and PK/PD modeling for our small-molecule programs in immune-mediated diseases. This role partners closely with cross-functional teams and reports to the Head of Clinical Pharmacology & DMPK. Specific responsibilities include but are not limited to: Lead clinical pharmacology strategy, dose selection, and PK/PD and biomarker planning across early and late-stage programs. Conduct and interpret PK, PK/PD, exposure-response, and simulation analyses using tools such as NONMEM, WinNonlin, R, Python, and Simcyp. Integrate translational and nonclinical PK/PD data to support FIH dose projections and DDI assessments. Oversee bioanalytical CROs, ensuring high-quality PK/PD/biomarker data and GLP/GCP compliance. Partner with Clinical Operations on sample management and protocol design. Communicate quantitative findings clearly and contribute to regulatory documents (protocols, IBs, INDs, NDAs, IMPDs). Collaborate across Clinical Development, Biostats/Data Science, Nonclinical, and Program Management. Key Requirements and Qualifications PhD, PharmD, or equivalent in Pharmacokinetics, Pharmacology, or related field. 6 to 8+ years of industry experience in Clinical Pharmacology, DMPK, or Quantitative Pharmacology. Strong expertise in PK, PK/PD, DMPK, and translational sciences. Proficiency with modeling/simulation platforms (NONMEM, WinNonlin, Simcyp, R, Python). Excellent communication, organization, and ability

Assistant Chemist, Alkoxylation Country / Location China We are a leading chemical company, with the best teams developing intelligent solutions for our customers, and for a sustainable future. We connect and develop people with diverse talents all over the world. For you, this means a variety of ways to progress. Not only your performance but also your personality matter to us, regardless of gender, age, ethnicity, orientation, and background. At BASF, careers develop from opportunities. About The Role Located in BCCS lab Jinshan. Afternoon to night shift to handle the alkoxylation 5L alkox reactor, including materials treatment, reactor DCS operation, reactor cleaning and maintenance Be responsible for execution and optimization of synthesis in local and regional innovation development projects Safety and lab cleaning for responsible lab / reactor / control room area How You Will Do It Pass the certification exam of authority for alkoxylation reactor operation. Pass the internal certification exam of EM research for alkoxylation reactor operation. Need to be expertise on reactor PID, setting, DCS system and reaction system. Project Support Execute local and regional innovation synthesis projects based on alkox surfactants Route cause analysis of chemical reactions Summary of results and supporting materials Key interfaces: AT/TS and development teams G-EMH/RA and G-EMI/AT Analysis e.g. OHV / CP / color and viscosity Safety coordination Comply with regulations concerning EHS according to BCCS rules and BASF standards according to

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