Principal Scientist, Functional Genomics
Xaira - South San Francisco, California, United States
Posted May 29, 2026
Benefits
- Parental leave
- Not verified
- Non-birth-parent leave
- Not verified
- Family-building benefits
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- Fertility benefits: Not verified
- Adoption assistance: Not verified
- Surrogacy assistance: Not verified
- Mental health support
- Not verified
- Relocation assistance
- Not verified
- Childcare support
- Not verified
- Learning budget
- Not verified
- Verification
- Not verified
- Salary
- $175K-$205K not verified - source not recorded; timestamp not recorded
- 401(k) match
- Not verified
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Market context
- U.S. role benchmark (BLS OEWS)
- $111,944 U.S. median for this role
- Projected growth (BLS Employment Projections)
- +13.7% - Much faster than average
70% above the BLS role benchmark for data and ml aggregate.
Matched to SOC 15-1252 - Data and ML aggregate by role bucket.
Source: U.S. Bureau of Labor Statistics, OEWS, May 2024 and Employment Projections, 2024-2034.
Schedule
- Shift type
- Not verified
- Weekend work
- Not verified
Application
- Cover letter
- Not verified
- Assessment
- Not verified
- Deadline
- Not stated
Where they hire
State eligibility is not yet verified.
About this role
Principal Scientist, Functional Genomics South San Francisco, California, United States About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London. About the Role Xaira is seeking a highly motivated and experienced Principal Scientist to join our Functional Genomics team with a focus on high-throughput perturbation platforms and single-cell genomics technologies. The ideal candidate will bring deep expertise in CRISPR-based screening approaches, perturb-seq, and large-scale functional genomics workflows, with experience generating high-quality datasets to support both therapeutic discovery and AI/ML modeling initiatives. This position offers the opportunity to contribute to cutting-edge efforts at the intersection of functional genomics, machine learning, and disease biology. You will work closely with AI/ML scientists, computational biologists, automation engineers, and disease biology teams to develop scalable perturbation workflows, implement new technologies, and drive high-quality data generation and experimental innovation across multiple therapeutic areas. Key Responsibilities - Lead high-throughput perturbation and functional genomics efforts supporting therapeutic discovery and AI/ML-driven research initiatives - Develop and implement advanced functional genomics technologies, including perturb-seq, CRISPRi/a, and
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