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General Proximity - San Francisco, CA

Posted Sep 17, 2024

Benefits

Parental leave
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Non-birth-parent leave
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Family-building benefits
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Mental health support
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Role

Seniority
Mid From the posting source checked Jun 20, 2026

Schedule

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Weekend work
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Company

Company stage
Seed From the posting source checked Jun 20, 2026
Equity
Offered From the posting source checked Jun 20, 2026

Application

Cover letter
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Deadline
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About this role

Other Positions San Francisco, CA Other Position(s) Interested in working with us but don't see a position that fits? Send us your resume/CV by applying here, and we will add you to our talent pool and reach out once we find a good fit! tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking first-rate scientists to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. About You High Agency. Initiative,

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