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Integrated Safety Analysis (ISA) Engineer

General Matter - Los Angeles, CA

Posted Apr 9, 2026

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About this role

Integrated Safety Analysis (ISA) Engineer Los Angeles, CA About the Company General Matter is enriching uranium in America. Our goal is to design, build, and operate the world's lowest-cost enrichment services in the United States. Our mission is to restore America's ability to produce nuclear fuel-fuel that will power AI, advanced manufacturing, critical industries, and the next generation of nuclear reactors. Ultimately, our work will help power national ambitions and enable a high-energy society. We were incubated by Founders Fund, like Anduril and Palantir before us, and are backed by top-tier investors. Our lean, world-class team of engineers and operators is applying a first-principles approach to solving the problem of nuclear fuel production. We are a mission-driven company with a culture of urgency, accountability, and transparency. Help us build a high-energy society by making the cleanest, safest form of baseload energy the most affordable. About This Role We are seeking a highly skilled Integrated Safety Analysis (ISA) Engineer to support the design, licensing, and operation of a new Nuclear Regulatory Commission (NRC)-licensed fuel enrichment facility regulated under 10 CFR Part 70. In this role, you will be a key contributor to ensuring that plant processes meet regulatory requirements for nuclear criticality safety, chemical safety, fire protection, and overall facility risk management. The ideal candidate has experience working in nuclear or high-hazard industries, strong analytical skills, and a deep understanding of risk-informed safety methodologies. Responsibilities - Lead and support development of Integrated Safety Analyses (ISAs) in accordance with 10 CFR Part

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