Senior Principal Programmer

Benefits

Parental leave

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Non-birth-parent leave

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Family-building benefits

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Mental health support

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Salary

$250K-$295K not verified - source not recorded; timestamp not recorded

401(k) match

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Schedule

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Weekend work

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Application

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Deadline

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About this role

Senior Principal Programmer San Francisco, CA or Remote or Hybrid About us: Braveheart Bio is a Bay Area-based biopharmaceutical company pioneering best-in-class therapies for cardiovascular disease. Our lead program is a next-generation myosin inhibitor, licensed from Hengrui Pharma, being developed to transform the treatment of hypertrophic cardiomyopathy (HCM)-the most common inherited cardiac disease. Currently in Phase 3 clinical development in China for the more common obstructive form of HCM, our candidate has demonstrated a compelling clinical profile that may position it as a best-in-class therapy with meaningful differentiation. With a proven leadership team, a strong financial foundation, and a high-value late-stage asset, Braveheart Bio represents an outstanding opportunity for ambitious, mission-driven professionals to make a tangible impact in a high-profile and rapidly evolving therapeutic area. The role: The Senior Principal Programmer will report into the VP, Biometrics and provide strategic and technical leadership for clinical programming activities across clinical development programs. This individual will oversee CRO programming deliverables, support global regulatory submissions, contribute to ongoing study monitoring, and collaborate closely with Biostatistics, Data Management, Clinical Operations, Regulatory, and external vendors to ensure high-quality, compliant, and timely delivery of clinical data outputs. Key responsibilities: - Oversee CRO programming activities, including SDTM, ADaM, TFLs, define.xml, reviewer's guides, and other clinical study or submission deliverables. - Review CRO programming plans, specifications, datasets, outputs, QC documentation, issue logs, and submission packages. - Ensure programming deliverables are accurate, traceable, reproducible, and compliant with CDISC standards and FDA/EMA expectations. - Serve as the internal programming lead

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