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Maze Therapeutics

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  • Senior Medical Director

    South San Francisco, CA

    unspecified $338K-$412K

    Senior Medical Director South San Francisco, CA The Position At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Medical Director to join our Clinical Sciences team and take a central role in pioneering the future of healthcare. As a Senior Medical Director, you'll be at the forefront of translating genetic insights into innovative treatments for patients . Your work will help drive the clinical development programs for game-changing therapies, starting with a small molecule that targets SLC6A19 - a novel therapeutic target for the treatment of chronic kidney disease and phenylketonuria . Maze Therapeutics has an exciting pipeline spanning both rare and common renal, cardiac, and metabolic diseases. In short, you'll play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives. To succeed in this role, you'll need to thrive in a fast-paced, collaborative environment. As a Senior Medical Director for one or more development programs, you will partner closely with cross-functional team members and other technical experts to design, conduct, and interpret the key clinical studies, including first-in-human and proof-of-concept trials. Your contributions will be highly visible and integral to the success of the Maze team. This position reports to the Head of Clinical Development . The Impact You'll Have - Lead the design, execution, and analysis of clinical trials for the SLC6A19 program and other early-stage clinical assets

  • Associate Director, Accounting

    South San Francisco, CA

    unspecified $187K-$229K

    Associate Director, Accounting South San Francisco, CA The Position The Finance team is looking for an Associate Director, Accounting . As the Associate Director, Accounting, you sit at the center of our company's financial integrity and operational execution. You'll lead core accounting operations, including payroll and month-end close, while ensuring accurate and timely financial reporting. With a hands-on mindset, you can balance getting into the details while setting direction, keeping the close moving forward and maintaining financial accuracy through attention to detail. You are a key business owner of internal controls, partnering closely with our auditors and cross-functional teams to design, operate , and continuously strengthen a control environment that can scale with our organization. You proactively identify risks, streamline process , and drive thoughtful improvements that enhance efficiency without sacrificing rigor. You develop and lead a high-performing accounting team, bringing clarity, accountability, and curiosity to everything you do, helping the company grow with confidence. This position reports to the VP , Corporate Controller. The Impact You'll Have - Accounting Operations & Close - oversee day-to-day accounting operations including payroll, general ledger operations, and month-end close activities. Review journal entries, account reconciliations, and supporting schedules. - Payroll Oversight - Partner with People Operations, Accounting team, and third-party payroll provider to ensure accurate , compliant, and timely payroll processing. - SOX 404 & Internal Controls - Own and maintain internal controls compliance for assigned processes, including documentation, risk assessments, control design, testing, and remediation. Serve as liaison with internal and external

  • Senior Director, Talent Acquisition & HRBP

    South San Francisco, CA

    unspecified $270K-$330K

    Senior Director, Talent Acquisition & HRBP South San Francisco, CA The Position We are seeking a Senior Director, Talent Acquisition & HRBP to lead hiring strategy and execution as the company advances its lead program into late ‑ stage development and prepares for continued organizational growth. This role is critical to ensure we attract, assess, and hire the talent required to deliver on our clinical and corporate priorities, while also serving as a strategic people partner to the business. The Senior Director will work closely with executive leadership, functional leaders, and the broader People team to build scalable, high ‑ quality hiring capabilities. Depending on the experience, interest, and capabilities of the individual hired, this role will also include Human Resources Business Partner (HRBP) responsibilities for select functions. The Impact You'll Have Talent Acquisition Strategy - Own and execute a company ‑ wide talent acquisition strategy aligned with late ‑ stage development milestones and growth plans. - Lead, coach, and develop the Talent Acquisition team, including recruiters, coordinators, and other recruiting resources as the organization scales. - Translate business priorities and program timelines into hiring plans and recruiting strategies. - Build proactive pipelines across core biotech talent markets and manage search firms, contractors, and recruiting vendors. - Advise leaders on hiring sequencing, role scoping, and talent tradeoffs as the organization scales. Hiring Execution & Process Excellence - Partner with functional leaders to recruit for critical clinical, scientific, technical, and operational roles. - Ensure hiring processes are efficient, rigorous, inclusive, and

  • Senior Director, Pharmaceutical Development

    South San Francisco, CA

    unspecified $257K-$315K

    Senior Director, Pharmaceutical Development South San Francisco, CA The Opportunity As Senior Director of Pharmaceutical Development, you lead all small molecule drug product activities and serve as a technical expert overseeing processes at CDMOs. You guide formulation and process development, manage scaleups, and proactively identify risks, gaps, and solutions across CMC. You'll dig into process and analytical data to resolve key challenges and advise on the best path forward. You bring strong cGMP expertise, support regulatory submissions, and collaborate across research, development, and technical operations. You coach teams for excellence, fuel intellectual curiosity, and champion inclusive, impactful leadership. This position reports to Vice President, Technical Operations. The Impact You'll Have - Lead small molecule drug product formulation, process development, and manufacturing activities with external CDMOs. - Ensure drug products meet quality, cost, time, safety, and operational goals. - Evaluate CDMO capabilities and recommend approaches for development and manufacturing. - Drive formulation, process development, scaleup, and tech transfer from initiation through regulatory approval. - Shape and optimize CMC strategy, project plans, and execution. - Monitor daily CMC activities, resolve challenges, and ensure cGMP compliance. - Ensure CDMO processes meet needs across formulation development, tox studies, clinical trials, and commercial launch. - Assess and implement new methods, tools, and technologies that elevate program success. - Analyze scientific data, review batch documentation, and contribute to regulatory filings (IND/IMPD/CTA/NDA). - Review and approve master and executed batch records; lead process improvements and drive solutions. - Lead technical investigations, identify root causes, and implement corrective

  • Director, Statistical Programming

    South San Francisco, CA

    unspecified $279K-$279K

    Director, Statistical Programming South San Francisco, CA The Opportunity Maze is looking for a Director of Statistical Progr ammi ng , who will help shap e the data foundation of our clinical development programs . In thi s role y ou'll collaborate closely with colleagues across Biostatistics, Clinical Data Management, Clinical Operations, and Regulatory Affairs, and oversee external vendors to keep our studies rigorous, high-quality, and ready for regulatory review . You'll report to the Vice President of Biometrics and lead the stra tegy and day-to-day execution of statistical programmi ng across multiple clinical studies . You r leadership will ensure we deliver reliable, efficient , and regulatory-c ompliant programming outputs that drive smarter decisions and ad vance our therapeutic programs. The Impact You'll Have - Define and implement statistical programming strategy , standards, and best practices across development programs . - Lead the design, development, validation , and maintenance of SAS macros, scripts, and applications supporting clinical data analysis, reporting, and regulatory deliverables (e.g., SDTM, ADaM datasets, TLFs) . - Ensure programming infrastructure is robust , scalable, and compliant with regulatory standards (e.g., FDA 21 CFR Part 11, GxP ), and supports reproducibility and audit readiness . - Drive automation and standardization of programming workflows to improve efficiency and consistency across studies . - Partner closely with Biostatistics, Clinical Data Management, Regulatory Affairs , and IT to define programming requirements, align on analysis/reporting deliverables, and ensure data integrity . - Represent the statistical programming function in cross-functional meetings and

  • Clinical Trial Manager, CKD

    South San Francisco, CA

    unspecified $143K-$175K

    Clinical Trial Manager, CKD South San Francisco, CA The Opportunity At Maze Therapeutics, we believe that precision medicine has the power to transform the lives of patients with both common and rare diseases. As a Clinical Trial Manager (CTM) at Maze Therapeutics, you'll play a hands-on role in co-leading and driving the execution of our Chronic Kidney Disease (CKD) clinical trials. You'll have the opportunity to contribute to mid to late -stage clinical studies, work cross-functionally with internal teams and external partners, and ensure trials run efficiently and with the highest quality standards. If you enjoy rolling up your sleeves, collaborating across teams, and bringing innovative medicines to patients, this role could be the perfect fit for you. The Impact You'll Have - Steer the execution of one or more of our Phase 2 CKD clinical trials; from protocol development to achievement of corporate and study milestones such as first patient in, interim analysis, database lock, and study report completion. - Manage external vendors including CROs, additional key vendors, and global investigative sites. - Ensure adherence to study protocols, SOPs , ICH GCP guidelines by overseeing monitoring activities at investigative sites. - Coordinate the development of study materials such as CRFs, ICFs , patient diaries. - Act as the voice of Clinical Operations on cross-functional teams, including the Study Execution Team (SET). - Partner with Clinical Operations and Clinical Science Team to engage with therapeutic area KOLs and Investigators. What We're Looking For - A degree in a scientific discipline

  • Director, Biostatistics

    South San Francisco, CA

    unspecified $228K-$280K

    Director, Biostatistics South San Francisco, CA The Position As the Director, Biostatistics, you will play an important role in shaping and supporting the clinical development of Maze's therapeutic programs. You will partner closely with Clinical Science, Regulatory Affairs, Clinical Pharmacology, Development Science, and Translational Science to ensure our clinical studies are robust, data-driven, and impactful. In this role, you'll oversee biostatistical strategy and execution, from study design through regulatory submissions, balancing hands-on expertise with strategic leadership. You will also represent Biostatistics on clinical study teams, guide interpretation of complex data, and oversee CRO partners to ensure high-quality statistical deliverables. The position will report to the Vice President, Biometrics. The Impact You'll Have - Serve as the biostatistics lead for clinical studies, providing expert input on study design, endpoints, and statistical strategy - Oversee and contribute to completion of all technical and operational statistical activities for a group of clinical trials. Ensure development and review of statistical analysis plans (SAPs), including complex and innovative methodologies - Collaborate with cross-functional partners in protocol development, study design discussions, and data interpretation - Partner with Statistical Programming to generate and validate analyses for internal use, publications, and regulatory submissions - Oversee CRO execution of statistical tasks: managing timelines, quality, and analytical approaches - Represent biostatistics in regulatory interactions (FDA, EMA, PMDA, etc.), contributing to briefing documents, meeting preparation, and responses to agency questions - Contribute to clinical study reports (CSRs), integrated summaries (ISS/ISE), and regulatory submissions (NDA/BLA/MAA) - Apply advanced statistical techniques to explore,

  • Associate Director, Regulatory Affairs

    South San Francisco, CA

    unspecified Salary not disclosed

    Associate Director, Regulatory Affairs South San Francisco, CA The Opportunity: Join Maze Therapeutics as an Associate Director, Regulatory Affairs , where you will play a critical role in advancing our clinical-stage programs by providing regulatory expertise and executional leadership. As a key member of the development team, you will collaborate with cross-functional teams to manage and support global regulatory activities. Reporting to the Senior Director of Regulatory Affairs, you will be responsible for preparing regulatory submissions, facilitating interactions with Health Authorities, and ensuring successful execution of regulatory plans. The Impact You'll Have : - Represent Regulatory Affairs for assigned programs, providing regulatory leadership and guidance, identifying regulatory risks and developing mitigation strategies, and leading the execution of regulatory plans. - Contribute to the development and implementation of regulatory strategies for assigned programs in alignment with corporate objectives and regulatory requirements. - Conduct regulatory research to provide recommendations for various regulatory scenarios, proactively identify risks, and inform regulatory strategies. - Plan and manage regulatory activities across clinical, nonclinical, and CMC functions to enable timely and efficient program advancement. - Lead the preparation and maintenance of regulatory submissions, including INDs/CTAs, periodic reports, expedited program requests, and Health Authority responses. - Provide regulatory input on key development documents, including clinical protocols, statistical analysis plans, and clinical/nonclinical study reports, to ensure alignment with regulatory expectations. - Support the planning, preparation, and execution of Health Authority interactions by contributing to meeting strategy, drafting briefing documents, and coordinating responses. - Collaborate with cross-functional teams and external