Ionis Pharmaceuticals jobs

Ioniverse (Data & AI) Platform Owner / Enterprise Solutions Architect 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION Click the title to view more details

Senior Research Associate/Senior Scientist, Pharmaceutical Development 2280 Faraday-USA; 2830 Whiptail Ionis Pharmaceuticals seeks an experienced pharmaceutical development scientist to support laboratory experiments, review development data, and author and standardize technical reports for injectable drug products in development. The ideal candidate will be an independent self-starter with experience in analytical, formulation and process support for early and late-stage development of oligonucleotide-based drug products including conjugated with small molecules, peptides and proteins. The successful candidate will be able to perform the following responsibilities with a high degree of independence and attention to detail.

Director, Computational Biology 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION; Remote We are seeking an exceptional computational biologist to lead target identification and multi-omics research efforts. In this role, you will drive the use of high-throughput, transcriptomics, epigenomics, proteomics, and functional genomics data to identify and prioritize novel therapeutic targets. You will bring a strategic, industry-wide perspective on the field - staying ahead of where it is moving and translating that into a differentiated approach which will align with Ionis's RNA-targeting and oligonucleotide platforms. You will lead a team of computational biologists, shape analytical strategy, and partner tightly with biology, human genetics, and drug discovery colleagues to bring forward the next wave of therapeutic targets.

Associate Director, Global Market Insights & Analytics - Cardiovascular 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION Ionis is seeking a market insights and analytics professional to join our rapidly growing Insights & Analytics team. Reporting to the Executive Director, Head of Strategic Market Insights, you will serve as the single point of contact for the Adult Neurology franchise, be responsible for developing and maintaining a deep understanding of the wholistic market perspective and resulting business implications through market research, data analytics, and competitive intelligence, as well as for driving data-backed forecasts. In this role, you will be a cross-functional collaborator with the broader Commercial, Finance, and R&D organizations, partnering at all levels of the business.

Associate Director/Director, Safety Conventions & Quality Standards 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION This position plays a critical lead role in establishing, maintaining, and continuously improving the quality and convention framework that underpins Patient Safety Operations at Ionis. The role is responsible for defining and enforcing case processing conventions, strategizing and executing quality control (QC) programs, trending and analyzing errors, and translating findings into training and procedural improvements. The position ensures that the PS&PV function operates with consistency, regulatory compliance, and a culture of continuous quality improvement across clinical and post-marketing programs.

Senior Clinical Data Manager, Clinical Data Science 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION Click the title to view more details

Associate Director, CMC Technical Services MA 1 Beacon-USA ION; 2280 Faraday-USA; Remote The candidate for Associate Director, CMC Technical Services will be responsible for managing drug product and packaging supply for Ionis commercial products. This individual will support domestic and global launches and be held accountable for managing relationships and project-related issues with the syringe and vial filling, assembly, and/or packaging suppliers. In addition, the CMC Technical Services SME will be contributing to the development of the long-term commercial supply strategy, including optimization of the existing external vendor portfolio to include manufacture, import/export, testing and release. The role includes review of vendor GMP documents (including but not limited to MBRs, specifications, change controls, validation plans).

Senior Scientist, Medicinal Chemistry 2855 Gazelle Ct HQ USA We are seeking a motivated and innovative individual to join our Medicinal Chemistry team as a Senior Scientist. The successful candidate will play a key role in synthesizing ligands or nucleoside monomers, incorporating them into therapeutic oligonucleotides, and performing bioconjugation of oligonucleotides to ligands targeting cell surface receptors. This position offers a unique opportunity to collaborate with cross-functional teams and contribute directly to the research and development of breakthrough therapies that have the potential to transform patients' lives.

Director, DMPK- Pharmacokinetics & Clinical Pharmacology 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION Click the title to view more details

Assistant Director/ Associate Director/ Director, Patient Safety Operations 2855 Gazelle Ct HQ USA; Remote Plays a key lead role in overseeing the multidisciplinary arena of Patient Safety Operations (clinical development and post marketing), supporting the global pharmacovigilance systems and associated processes. Requires close cross-functional collaboration and a deep understanding of interdependent safety data flows as tasks can be assigned as independent projects. Ensures compliance with applicable regulatory requirements and internal procedures while supporting the overall strategy, quality, and efficiency of the Patient Safety and Pharmacovigilance function.

Director, Strategic Market Insights – Tryngolza 2850 Gazelle Ct. Ionis is seeking a market insights team leader with broad strategic and consultative experience to join our rapidly growing Insights and Analytics team. Reporting to the Head of Global Market Insights, you will be responsible for developing and maintaining a deep understanding of the wholistic market perspective and resulting business implications through market research, data analytics, and competitive intelligence, as well as for enabling data-backed forecasts for key programs. In this role, you will collaborate cross-functionally with the broader Commercial, Medical, Finance, and R&D organizations, partnering at all levels of the business.

Senior Scientist, Formulation and Delivery Sciences 2855 Gazelle Ct HQ USA Click the title to view more details

Director, Drug Safety Surveillance (PV Scientist) Remote The Associate Director/Director of Drug Safety Surveillance (PV Scientist) provides safety science and pharmacovigilance support to assigned molecules within Ionis portfolio. Major areas of responsibilities include ensuring high quality of aggregate report production, development of risk management documents in collaboration with Drug Safety Physicians, safety review meeting coordination, signal detection activities as well as evaluating emerging safety data from all sources, identifying and managing safety signal(s), authoring key sections of periodic safety reports and other PV documents, and providing safety support for clinical development. This position will report to the Executive Director of Drug Safety Surveillance within Drug Safety/PV.

Research Associate, Neurology 2855 Gazelle Ct HQ USA We are seeking a motivated and skilled individual to join our Neurology Research group and participate in drug discovery for rare and severe disorders with high unmet medical need. Key responsibilities include administration of antisense oligonucleotides (ASOs), tissue sample processing, data collection, and analysis. The successful candidate will have demonstrated aptitude for laboratory work with a strong commitment to the scientific process and will be capable of working independently in a fast-paced environment.

Temporary Research Associate / Scientist 2855 Gazelle Ct HQ USA We are seeking a highly motivated and skilled research associate or scientist to join our medicinal chemistry team. Experience with oligonucleotide chemistry is highly preferred. The successful candidate will play a key role in the development and optimization of oligonucleotide conjugates to enable targeted delivery of nucleic acid therapeutics.

Assistant Director, Trade Compliance & Logistics 2850 Gazelle Ct.; Remote Click the title to view more details

Clinical Account Specialist (CAS), NW Phoenix, AZ Remote; AZ Arizona - USA, ION Click the title to view more details

Assistant Director, Drug Safety Surveillance 2855 Gazelle Ct HQ USA Click the title to view more details

Director, US Value & Access Remote Click the title to view more details

Executive Director, US Value & Access Remote The Executive Director, Value & Access serves as the senior U.S. enterprise leader accountable for defining and advancing U.S. payer access, reimbursement, and value strategy across Ionis' commercial portfolio. This role shapes enterprise access strategy to ensure optimal patient access, sustainable coverage, and long-term value realization for Ionis therapies. As a second-line leader, the Executive Director sets the strategic vision, operating model, and performance standards for the U.S. Value & Access function, leading Director-level leaders and building a high-performing, scalable organization. This individual will play a critical role in influencing enterprise decision-making by integrating payer insights into brand strategy, evidence planning, and lifecycle management.

Computational Biology Post Doctorate Fellow, Biomarker Department 2855 Gazelle Ct HQ USA Click the title to view more details

Vice President, Clinical Development – Cardiovascular 2855 Gazelle Ct HQ USA The Vice President, Clinical Development - Cardiovascular is a board-certified cardiologist (M.D.) with deep expertise in lipid disorders and cardiometabolic disease who is responsible for defining and driving the clinical development strategy for Ionis' cardiovascular portfolio, including Phase 4 and post-marketing programs. This is a hands-on, working VP role that combines strategic leadership with active ownership of key studies and deliverables and plays a critical role in enterprise-level development and portfolio decisions.

Temp Toxicology Operations Associate 2855 Gazelle Ct HQ USA We are seeking a highly organized and detail-oriented professional to join our Toxicology team as a Study Coordinator. In this cross-functional role, you will serve as the primary liaison between Ionis, our contract research organizations (CROs), and various internal teams. At Ionis, we are committed to fostering a diverse and inclusive workplace where all individuals are valued, respected, and empowered to contribute their unique perspectives.

Post Doctorate Fellow, Discovering Receptors That Enable Targeted Oligonucleotide Delivery to Immune Cells 2855 Gazelle Ct HQ USA We are seeking a highly motivated and highly productive Post Doctorate Fellow to contribute to advancing targeted RNA-therapeutics delivery to immune cells. This role offers a unique opportunity to gain deep research experience in a fast-paced industry environment while making a meaningful contribution to the development of next-generation RNA medicines.