Ionis Pharmaceuticals jobs

Ioniverse (Data & AI) Platform Owner / Enterprise Solutions Architect 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION Click the title to view more details

Senior Research Associate/Senior Scientist, Pharmaceutical Development 2280 Faraday-USA; 2830 Whiptail Ionis Pharmaceuticals seeks an experienced pharmaceutical development scientist to support laboratory experiments, review development data, and author and standardize technical reports for injectable drug products in development. The ideal candidate will be an independent self-starter with experience in analytical, formulation and process support for early and late-stage development of oligonucleotide-based drug products including conjugated with small molecules, peptides and proteins. The successful candidate will be able to perform the following responsibilities with a high degree of independence and attention to detail.

Director, Computational Biology 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION; Remote We are seeking an exceptional computational biologist to lead target identification and multi-omics research efforts. In this role, you will drive the use of high-throughput, transcriptomics, epigenomics, proteomics, and functional genomics data to identify and prioritize novel therapeutic targets. You will bring a strategic, industry-wide perspective on the field - staying ahead of where it is moving and translating that into a differentiated approach which will align with Ionis's RNA-targeting and oligonucleotide platforms. You will lead a team of computational biologists, shape analytical strategy, and partner tightly with biology, human genetics, and drug discovery colleagues to bring forward the next wave of therapeutic targets.

Research Associate II, Analytical Development & Quality Control (ADQC) 2280 Faraday-USA; 2282 Faraday-USA Seeking an experienced analytical chemist to join our Analytical Development & Quality Control (ADQC) group at the Research Associate II level. The ideal candidate will be familiar with HPLC and other chemistry techniques, possess a strong work ethic and strong technical background, demonstrate excellent oral and written communication skills, and have experience working in a GMP environment. The successful candidate will be able to perform the following responsibilities with a high degree of independence and attention to detail.

Associate Director, CMC Technical Services MA 1 Beacon-USA ION; 2280 Faraday-USA; Remote The candidate for Associate Director, CMC Technical Services will be responsible for managing drug product and packaging supply for Ionis commercial products. This individual will support domestic and global launches and be held accountable for managing relationships and project-related issues with the syringe and vial filling, assembly, and/or packaging suppliers. In addition, the CMC Technical Services SME will be contributing to the development of the long-term commercial supply strategy, including optimization of the existing external vendor portfolio to include manufacture, import/export, testing and release. The role includes review of vendor GMP documents (including but not limited to MBRs, specifications, change controls, validation plans).

Associate Director, Global Market Insights & Analytics - Cardiovascular 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION Ionis is seeking a market insights and analytics professional to join our rapidly growing Insights & Analytics team. Reporting to the Executive Director, Head of Strategic Market Insights, you will serve as the single point of contact for the Adult Neurology franchise, be responsible for developing and maintaining a deep understanding of the wholistic market perspective and resulting business implications through market research, data analytics, and competitive intelligence, as well as for driving data-backed forecasts. In this role, you will be a cross-functional collaborator with the broader Commercial, Finance, and R&D organizations, partnering at all levels of the business.

Associate Director/Director, Safety Conventions & Quality Standards 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION This position plays a critical lead role in establishing, maintaining, and continuously improving the quality and convention framework that underpins Patient Safety Operations at Ionis. The role is responsible for defining and enforcing case processing conventions, strategizing and executing quality control (QC) programs, trending and analyzing errors, and translating findings into training and procedural improvements. The position ensures that the PS&PV function operates with consistency, regulatory compliance, and a culture of continuous quality improvement across clinical and post-marketing programs.

Principal Medical Writer - Regulatory and Medical Writing 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION; Remote The Senior Medical Writer will collaborate with internal teams to lead, write, and manage completion of clinical regulatory documents. This role is for an individual contributor, reporting to the Executive Director (Head) of Regulatory and Medical Writing. This role includes responsibilities throughout the lifecycle of a document including working cross-functionally to interpret source information (including leading data interpretation meetings), leading key messaging meetings, writing content following US and international regulations (including Marketing Application Module 2 summary documents), conducting quality control (QC) reviews, resolving Quality Assurance (QA) audit findings, and working with Regulatory Operations for publishing and submission.

Senior Clinical Data Manager, Clinical Data Science 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION Click the title to view more details

Director, Strategic Market Insights – Tryngolza 2850 Gazelle Ct. Ionis is seeking a market insights team leader with broad strategic and consultative experience to join our rapidly growing Insights and Analytics team. Reporting to the Head of Global Market Insights, you will be responsible for developing and maintaining a deep understanding of the wholistic market perspective and resulting business implications through market research, data analytics, and competitive intelligence, as well as for enabling data-backed forecasts for key programs. In this role, you will collaborate cross-functionally with the broader Commercial, Medical, Finance, and R&D organizations, partnering at all levels of the business.

Director, DMPK- Pharmacokinetics & Clinical Pharmacology 2855 Gazelle Ct HQ USA; MA 1 Beacon-USA ION Click the title to view more details

Senior Scientist, Medicinal Chemistry 2855 Gazelle Ct HQ USA We are seeking a motivated and innovative individual to join our Medicinal Chemistry team as a Senior Scientist. The successful candidate will play a key role in synthesizing ligands or nucleoside monomers, incorporating them into therapeutic oligonucleotides, and performing bioconjugation of oligonucleotides to ligands targeting cell surface receptors. This position offers a unique opportunity to collaborate with cross-functional teams and contribute directly to the research and development of breakthrough therapies that have the potential to transform patients' lives.

Assistant Director/ Associate Director/ Director, Patient Safety Operations 2855 Gazelle Ct HQ USA; Remote Plays a key lead role in overseeing the multidisciplinary arena of Patient Safety Operations (clinical development and post marketing), supporting the global pharmacovigilance systems and associated processes. Requires close cross-functional collaboration and a deep understanding of interdependent safety data flows as tasks can be assigned as independent projects. Ensures compliance with applicable regulatory requirements and internal procedures while supporting the overall strategy, quality, and efficiency of the Patient Safety and Pharmacovigilance function.

Senior Scientist, Formulation and Delivery Sciences 2855 Gazelle Ct HQ USA Click the title to view more details

Director, Drug Safety Surveillance (PV Scientist) Remote The Associate Director/Director of Drug Safety Surveillance (PV Scientist) provides safety science and pharmacovigilance support to assigned molecules within Ionis portfolio. Major areas of responsibilities include ensuring high quality of aggregate report production, development of risk management documents in collaboration with Drug Safety Physicians, safety review meeting coordination, signal detection activities as well as evaluating emerging safety data from all sources, identifying and managing safety signal(s), authoring key sections of periodic safety reports and other PV documents, and providing safety support for clinical development. This position will report to the Executive Director of Drug Safety Surveillance within Drug Safety/PV.

Research Associate, Neurology 2855 Gazelle Ct HQ USA We are seeking a motivated and skilled individual to join our Neurology Research group and participate in drug discovery for rare and severe disorders with high unmet medical need. Key responsibilities include administration of antisense oligonucleotides (ASOs), tissue sample processing, data collection, and analysis. The successful candidate will have demonstrated aptitude for laboratory work with a strong commitment to the scientific process and will be capable of working independently in a fast-paced environment.

Temporary Research Associate / Scientist 2855 Gazelle Ct HQ USA We are seeking a highly motivated and skilled research associate or scientist to join our medicinal chemistry team. Experience with oligonucleotide chemistry is highly preferred. The successful candidate will play a key role in the development and optimization of oligonucleotide conjugates to enable targeted delivery of nucleic acid therapeutics.

Clinical Account Specialist (CAS), NW Phoenix, AZ Remote; AZ Arizona - USA, ION Click the title to view more details

Assistant Director, Trade Compliance & Logistics 2850 Gazelle Ct.; Remote Click the title to view more details

Director of Clinical Strategic Sourcing 2855 Gazelle Ct HQ USA The primary responsibility of this role is to lead the strategic sourcing and procurement activities for Clinical Development, ensuring alignment with long-term organizational goals. This role will play a critical part in developing and optimizing procurement processes, strengthening supplier partnerships, and ensuring that the Clinical Development suppliers secure high-quality services at the best overall value. Effective category management within Clinical Development is expected to significantly contribute to the organization's operational excellence and overall success.

Assistant Director, Drug Safety Surveillance 2855 Gazelle Ct HQ USA Click the title to view more details

Computational Biology Post Doctorate Fellow, Biomarker Department 2855 Gazelle Ct HQ USA Click the title to view more details

Vice President, Clinical Development – Cardiovascular 2855 Gazelle Ct HQ USA The Vice President, Clinical Development - Cardiovascular is a board-certified cardiologist (M.D.) with deep expertise in lipid disorders and cardiometabolic disease who is responsible for defining and driving the clinical development strategy for Ionis' cardiovascular portfolio, including Phase 4 and post-marketing programs. This is a hands-on, working VP role that combines strategic leadership with active ownership of key studies and deliverables and plays a critical role in enterprise-level development and portfolio decisions.

Director, US Value & Access Remote Click the title to view more details