Sr. Bioinformatics Scientist – cfDNA Technology Development

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Not verified last checked Jun 13, 2026

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401(k) match

Listed Source: EMPLR_CONTRIB_INCOME_AMT. source Last checked Jun 13, 2026.

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About this role

Sr. Bioinformatics Scientist – cfDNA Technology Development Fremont, CA Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency. Days Onsite: Monday & Tuesday Summary: The Bioinformatics Senior Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Bioinformatics Scientist will be working alongside our clinical evidence generation teams, applying our cell-free solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection. Responsibilities: Design, develop, and build upon our novel cell-free platforms and products, including our NeXT Personal MRD liquid biopsy platform Work cross-functionally to translate collaborative findings into actively developed cutting-edge products Design and execute scientific projects and

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