Head of Discovery

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About this role

Head of Discovery New York HQ 🗽 | Remote The Role Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates. Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible. We're already generating therapies that traditional approaches cannot reach. The hardest problems in both AI and biology are being solved here, and there is room for you to own one. Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator. You are a drug hunter. You own the scientific strategy behind Output's drug discovery programs. You help select targets for our pipeline, evaluate what the models generate, and make the scientific decisions that advance candidates from computational generation to real-world testing. - You will identify and evaluate therapeutic targets, building the scientific rationale for which programs to pursue and why - You will analyze model outputs to assess drug candidates, evaluating biological plausibility, therapeutic potential, and readiness for advancement - You will prioritize candidates and make scientific go/no-go decisions, advancing the strongest compounds through the discovery pipeline - You will manage CRO partnerships for candidate synthesis and biological testing, designing experiments that validate or refine drug design hypotheses - You will work closely with the founders and model team, bringing drug discovery expertise to model evaluation and development priorities - You will stay current

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