Principal Machine Learning Scientist

Benefits

Parental leave

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Family-building benefits

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Mental health support

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Verification

Not verified last checked Jun 13, 2026

Salary

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401(k) match

Listed Source: EMPLR_CONTRIB_INCOME_AMT. source Last checked Jun 13, 2026.

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Schedule

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Application

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About this role

Principal Machine Learning Scientist Remote (WFH) At Adaptive, we're Powering the Age of Immune Medicine. Our goal is to harness the power of the adaptive immune system to transform the way diseases are diagnosed and treated. As an Adapter, you'll have the opportunity to make a difference in people's lives. With Adaptive, you'll create a career highlight through collaboration with bright, curious colleagues working at the apex of innovation and application. It's time for your next chapter. Discover your story with Adaptive. Position Overview Adaptive Biotechnologies is seeking a Principal Machine Learning Scientist to lead the development of deep learning models for TCR-pMHC specificity prediction. In this role, you will leverage a large and growing proprietary dataset to design, train, and evaluate models that predict interactions between T cell receptors and peptide-MHC complexes. Your work will focus on developing new approaches that integrate sequence and structural information and rigorously testing their performance in practical settings. You will work closely with computational scientists, immunologists, and machine learning engineers across the organization. The team brings together expertise in immune biology, experimental assay development, and large-scale machine learning, with access to proprietary immune receptor datasets, shared GPU infrastructure, and engineering support for model development and training. This role sits at the intersection of modeling and experimental data generation. As model results highlight gaps in available data or suggest new experimental directions, newly generated datasets can provide additional signal for improving and validating the models. Models developed in this role contribute directly to diagnostic

Read the full description at www.adaptivebiotech.com. FewerJobs shows a source-linked preview and links to the original posting.