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Nurix Therapeutics Inc

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  • VP, Medical Affairs – Hematology-Oncology

    Brisbane, CA

    unspecified Salary not disclosed

    VP, Medical Affairs – Hematology-Oncology Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position Overview Nurix Therapeutics is seeking a Vice President, Medical Affairs, Hematology-Oncology to build, expand, and lead a best-in-class Medical Affairs organization supporting the company's transition from a clinical-stage biotechnology company toward commercialization as its hematology-oncology portfolio advances into late-stage clinical development. This executive will provide strategic and operational leadership across the full Medical Affairs function, including medical strategy, field medical, scientific communications, evidence generation, thought leader engagement, medical information, and launch readiness. The role will play a central role in shaping the scientific and medical strategy for Nurix's targeted protein degradation portfolio and helping define the company's external scientific leadership in hematologic malignancies. The role will be a key cross-functional partner to Clinical Development, Commercial, Market Access, Regulatory, Legal, and Compliance as Nurix plans and executes future commercialization activities. This leader will contribute broadly to portfolio strategy, lifecycle planning, and enterprise-level

  • Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK

    Brisbane, CA

    unspecified $93K-$107K

    Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position Nurix Therapeutics is searching for a motivated Research Associate to join our Bioanalytical-In Vitro DMPK team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. We are seeking a highly motivated research associate to characterize the in vitro and in vivo ADME properties of drug candidates. The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments. The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrices (e.g. blood, plasma, tissue, tumor, CSF, etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all in vitro and in vivo studies. The successful candidate will have extensive experience in bioanalytical

  • Vice President of Marketing

    Brisbane, CA

    unspecified Salary not disclosed

    Vice President of Marketing Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position We are seeking a dynamic and experienced Vice President of Marketing with extensive experience launching new hematology / oncology products and incorporating commercial strategy into early development programs. The core objective is to build, lead and execute all aspects of Nurix Therapeutics marketing efforts. This individual will be responsible for developing all marketing strategies and tactical readiness for the commercialization of Nurix Therapeutics assets. In addition, this role will be accountable for driving commercial strategy in support of lifecycle management and our pipeline. Accountable for developing and executing all Global and US Marketing strategies that align with the overall company strategic imperatives. Ensure strategic alignment with cross-functional commercial partners in commercial insights and analytics, market access, and sales in order to produce high quality marketing efforts that achieve company performance objectives - Build and implement the marketing plan including, but not limited

  • SRA Protein Expression

    Brisbane, CA

    unspecified $56-$86/hr

    SRA Protein Expression Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position Summary: Research Associate III - Scientist I Protein Expression Contractor Nurix Therapeutics, Inc. is seeking a detail-oriented and experienced Protein Expression Research Associate Contractor to join the DEL and Protein Sciences team. This individual will work cross functionally with internal stakeholders to plan, coordinate, and execute all operational activities required for analytical scale and preparative scale expression of recombinant proteins in baculovirus and mammalian cell systems. Additionally, they will be responsible for documentation of expression conditions and results in internal databases and electronic lab notebook systems. This is an onsite role. Qualifications - MS or equivalent with 2+ years of relevant experience, or Ph.D. - This position requires 2+ years of experience working with insect cell lines and baculovirus expression of recombinant proteins. Additional experience working with recombinant protein expression in mammalian cells (e.g. HEK293) is a plus. Industry experience preferred with exemplified

  • Scientist II - Structural Biology

    Brisbane, CA

    unspecified Salary not disclosed

    Scientist II - Structural Biology Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position Summary This role is located at the interface of Nurix's DEL driven drug discovery engine and preclinical drug development platform. The strategic impact of this role is the elucidation and communication of small molecule interactions with drug targets to provide mechanistic understanding and guide design of clinical drug candidates. As a member of the early discovery department, you will make key contributions to validation and characterization of novel chemical matter for our targeted protein degradation platform. In addition to that, you will participate in multiple small and agile teams of drug discovery veterans and help achieve discovery and development milestones. Key Responsibilities - Design and execute end-to-end gene-to-structure workflows: construct design, protein engineering, experimental planning, and structure determination - Determine high-resolution structures of protein-ligand and protein complexes using X-ray crystallography and cryo-EM - Own all aspects of sample preparation, data collection,

  • Manager, Analytical Development and Quality Control (Brisbane, CA)

    Brisbane, CA

    unspecified $147K-$198K

    Manager, Analytical Development and Quality Control (Brisbane, CA) Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position The Manager, Analytical Development and Quality Control provides strategic and technical leadership for analytical CMC activities across multiple programs, with a strong emphasis on technology transfer and knowledge management. This role ensures successful transfer of analytical methods and associated knowledge to internal teams and external stakeholders, enabling consistent execution across development and manufacturing sites. The position requires deep expertise in analytical method development, validation, transfer, and lifecycle management in alignment with ICH guidelines, along with the ability to interpret data from a range of analytical techniques to support sound technical decision-making. In addition, this role is responsible for establishing and clearly communicating analytical control strategies across cross-functional teams, ensuring alignment and scientific rigor. The Manager drives robust knowledge management practices through high-quality technical writing, documentation, and data governance, including authoring and reviewing validation, transfer, and investigation reports. Strong

  • SRA DNA Encoded Library Technology - (Brisbane, CA)

    Brisbane, CA

    unspecified $102K-$147K

    SRA DNA Encoded Library Technology - (Brisbane, CA) Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Research Associate III/Scientist I, DNA Encoded Library Technology - Nurix Brisbane Position We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix's DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation. Key responsibilities: - Design and validate novel DEL library builds. - Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space. - Construct DEL libraries to support the in-house library production efforts. - Work with external partners to support our DEL synthesis and hit follow up strategies. - Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization. - Contribute to platform automation and technology development efforts. - Present results,

  • Medical Director, Drug Safety

    Brisbane, CA

    unspecified Salary not disclosed

    Medical Director, Drug Safety Brisbane, CA Title: Medical Director, Drug Safety Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position: As a Medical Director, Drug Safety you will play a key role in ensuring the safety of patients in Nurix's clinical trials. You will apply your clinical expertise to evaluate safety data, guide benefit-risk assessments and help shape the pharmacovigilance strategy for Nurix's emerging therapies. You will report to the VP of pharmacovigilance and work closely with colleagues in clinicaldevelopment, regulatory affairs, and clinical research to interpret emerging safety signals, support regulatory submissions, and maintain a strong safety framework during clinical development and transition into the post-marketing phase. Your insights will help inform critical decisions about patient safety, risk management, and the overall development strategy for our products. This role is well suited for a physician who enjoys working at the intersection of non-clinical data, clinical medicine, data interpretation, and drug development, and who wants to have a

  • Senior Clinical Trial Manager ~ Contract Position

    Brisbane, CA

    unspecified Salary not disclosed

    Senior Clinical Trial Manager ~ Contract Position Brisbane, CA Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease Nurix is seeking a Senior Clinical Trial Manager to join the Clinical Operations team. This individual will be responsible for management of global regions and/or clinical programs. They will lead study team, vendors, clinical monitors and clinical sites throughout the life cycle of a clinical trial. This individual will be able to manage clinical regions or trial(s) and have broad involvement in work central to Nurix's strategic goals. They will apply existing technical skills, learn new skills, and play a key role in clinical development of the programs. As an early hire, they'll be influential in championing and developing Nurix's culture. The Senior Clinical Trial Manager is responsible for the successful implementation of a clinical trial, independently, from start-up to close-out. Experience in managing cross-functional teams, vendor oversight, knowledge of applicable regulatory requirements and developing junior staff will be essential to

  • Senior Scientist, Analytical Development and Quality Control (Drug Product)

    Brisbane, CA

    unspecified Salary not disclosed

    Senior Scientist, Analytical Development and Quality Control (Drug Product) Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position Nurix Therapeutics seeks an experienced Senior Scientist to join the Analytical Development and Quality Control group. The Senior Scientist will be responsible for drug product (DP) analytical development, including method development, oversight of method validation at CDMOs, and lifecycle management in support of Nurix's oncology and inflammation & immunology (I&I) programs. This position provides technical oversight of analytical method development, validation, and testing conducted at external CDMO/CRO partners. The Senior Scientist will author analytical development reports and IND/IMPD/NDA sections and support late-phase tech transfer and validation activities. This role will also contribute to analytical development for new drug products and dosage forms. The Senior Scientist will work closely in cross-functional teams to ensure alignment and integration of analytical and QC strategies across development stages. The ideal candidate will have expertise in chromatographic and dissolution method development, stability

  • Scientist, Analytical Development and Quality Control

    Brisbane, CA

    unspecified $143K-$161K

    Scientist, Analytical Development and Quality Control Brisbane, CA Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position Nurix Therapeutics seeks an experienced Scientist to join the Analytical Development and Quality Control group. The Scientist will conduct analytical method development and material characterization studies to inform drug substance and drug product development. They will also provide operational oversight at external CDMO/CTL partners, manage reference standards and impurity markers, collaborate in CMC risk management, and author technical reports. In Nurix's laboratories, the Scientist will characterize material attributes and impurities by high resolution mass spectrometric and multidimensional chromatographic techniques. They will determine impurity structures, characterize material stability, and elucidate mechanisms of degradation. They will employ state of the art QbD approaches to develop and troubleshoot chromatographic test methods to accelerate and derisk QC activities performed externally at CDMOs and CTLs. The Scientist will critically evaluate characterization data and communicate results in multidisciplinary teams. The ideal candidate must have demonstrated expertise

  • Sr. Director, Head of Regulatory & Medical Writing

    Brisbane, California, United States

    unspecified $254K-$289K

    Sr. Director, Head of Regulatory & Medical Writing Brisbane, California, United States Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Job Summary: As a key member of the cross-functional Development Team responsible for providing regulatory writing expertise and leadership to formulate the writing strategy for key regulatory documents for submission. The Sr. Director, Head of Regulatory & Medical Writing will be responsible for providing guidance to the medical and or regulatory writing group (contractors and internal writers) assigned to deliverables and ensuring appropriate work allocation and document preparation.; will also provide review and substantive editing of documents to ensure delivery of high-quality documents. This individual will work effectively with many other functional groups, including with Clinical Scientist(s), Medical Monitors, Regulatory and other functions as applicable, and collaborate with clinical medical writing as applicable to ensure scientific excellence in the execution of clinical trials. The Head of Regulatory Writing will build a medical writing group internally when appropriate. Reporting

  • Senior Director, Regulatory Affairs (Strategy, Hematology Oncology)

    Brisbane, California, United States

    unspecified Salary not disclosed

    Senior Director, Regulatory Affairs (Strategy, Hematology Oncology) Brisbane, California, United States Position Title: Senior Director, Regulatory Affairs (Strategy, Hematology Oncology) Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Job Summary: Nurix Therapeutics, Inc. is seeking a Senior Director Regulatory Affairs (Strategy, Hematology Oncology) to join the Regulatory team. The successful candidate will be a core member of the Regulatory team and will be responsible for helping build and execute on global regulatory strategy, objectives, policies and programs pertaining to development and future marketing of products for guiding and executing upon regulatory strategy of compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities. This includes supporting regulatory activities to enable clinical development plans and studies, working cross-functionally across the organization. Responsibilities: - Provides regulatory strategic direction and support for assigned global development programs/development program activities - Assists Sr. Regulatory Affairs staff with their development program activities and deliverables

  • Vice President, Head of Alliance Management and Program Management ~ Onsite

    Brisbane, CA

    onsite Salary not disclosed

    Vice President, Head of Alliance Management and Program Management ~ Onsite Brisbane, CA Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Vice President, Head of Alliance Management and Program Management Nurix Therapeutics is seeking an accomplished and strategic Vice President, Head of Alliance Management and Program Management to lead both our external collaborations with pharmaceutical partners and the internal coordination of our late stage hematology/oncology program. In addition to leading a high-impact alliance, this role will drive internal program management discipline, ensuring organizational awareness of program priorities, clear accountability for key workstreams, aligned roadmaps across functions, and transparent communication of status and risks to senior leadership. The ideal candidate is a dynamic leader who thrives in complexity, bridges science and business, and delivers executional excellence across partnerships and programs. Key Responsibilities - Alliance Leadership and Strategy - Serve as the primary point of contact between Nurix Therapeutics and its pharmaceutical partners, fostering a transparent, collaborative, and goal-oriented relationship.

  • Associate Director, Computer Systems Assurance (Quality)

    Brisbane, CA

    unspecified $171K-$193K

    Associate Director, Computer Systems Assurance (Quality) Brisbane, CA Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position The Senior Manager / Associate Director, Computer Systems Assurance (CSA) is an important technical and operational leader within the Nurix Quality Systems organization, responsible for owning and advancing Nurix's computer systems assurance program. As a virtual drug developer, Nurix operates through a lean internal infrastructure and relies on a curated ecosystem of Software-as-a-Service (SaaS) and cloud-hosted platforms to support GxP-regulated activities across clinical development, quality operations, manufacturing oversight, and regulatory submissions. This role will serve as the primary subject matter expert and program owner for all CSA and computerized system validation (CSV) activities at Nurix. Reporting to the Vice President / Senior Director, Quality Systems, this individual will establish and maintain Nurix's risk-based CSA framework aligned with current regulatory expectations, including the FDA's 2022 guidance on computer software assurance, GAMP 5 (2nd edition), and applicable 21 CFR Part 11 and Annex

  • Director, Regulatory Affairs

    Brisbane, California, United States

    unspecified Salary not disclosed

    Director, Regulatory Affairs Brisbane, California, United States Position Title: Director, Regulatory Affairs (Strategy, Immunology and Inflammation) Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Nurix Therapeutics, Inc. is seeking a Director, Regulatory Affairs (Strategy, I&I) to join the Regulatory team. The successful candidate will be a core member of the Regulatory team and will serve as the global regulatory lead (GRL) for the immunology and inflation therapeutic area. This role will be responsible for developing the global regulatory strategy in collaboration with key internal stakeholders, as well as tactical implementation of that strategy guiding and executing compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities. This position works cross-functionally with regulatory affairs and clinical development organizations to facilitate the completion of regulatory filing documentation according to company timelines. It also ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as required. This position is

  • Biosample Manager

    Brisbane, CA

    unspecified Salary not disclosed

    Biosample Manager Brisbane, CA Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease. Position: Biosample Manager Nurix Therapeutics, Inc. is seeking a Biosample Manager to join the Clinical Operations team. This is an onsite role. This individual will work cross functionally, with both internal and external stakeholders, to plan, coordinate, and oversee all operational activities required to manage the lifecycle of the clinical biosamples and support translational research. Responsibilities: Study Management - Provide guidance during protocol and informed consent form development to ensure logistical feasibility of biosample handling, alignment with planned analyses and ICH/GCP compliance - Participate in the CRF development process to ensure that biosample information is appropriately captured for sample tracking and reconciliation purposes - Serve as the functional lead as a member of the Clinical Study Teams and provide regular biosample metrics/trends and status updates - Partner with cross-functional teams to ensure timely delivery of biosample data to meet publication and study goals Biosample and Vendor

  • Senior Manager, Quality Operations

    Brisbane, CA

    unspecified $138K-$156K

    Senior Manager, Quality Operations Brisbane, CA Senior Manager, Quality Operations Nurix Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation therapeutics. Leveraging our proprietary DELigase platform, we design small molecules that harness the body's own protein disposal system to selectively eliminate disease-causing proteins. Our pipeline spans oncology and immune-mediated diseases, and our team is united by a commitment to scientific excellence and meaningful impact for patients. We are a team of scientists, innovators, and problem-solvers committed to improving patient lives. We value integrity in everything we do - from the bench to the boardroom - and we foster an environment where every voice is heard and every contribution matters. Position The Senior Manager, Quality Operations is an important operational and technical contributor within the Nurix Quality organization, responsible for supporting the quality operations and GMP compliance activities that underpin Nurix's clinical development programs. This role will partner closely with CMC teams, CDMOs, and internal stakeholders to ensure quality oversight across drug manufacturing, laboratory operations, auditing, and inspection readiness. Reporting to the Senior Director, Quality, the Senior Manager will execute essential quality systems activities including deviation management, change control, CAPA, batch record review, and audit support. This individual will demonstrate strong independent judgment, meticulous attention to detail, and the ability to collaborate effectively across functions in a dynamic, early to late clinical-stage environment where quality and program timelines are closely intertwined Responsibilities Drug Manufacturing Quality Operations - Execute and support quality systems operations

  • Senior Manager, Regulatory Operations

    Brisbane, CA

    unspecified Salary not disclosed

    Senior Manager, Regulatory Operations Brisbane, CA Company: Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase (BTK), a B-cell signaling protein, and an inhibitor of Casitas B-lineage lymphoma proto-oncogene-B (CBL-B), an E3 ligase that regulates T cell activation. Nurix is also progressing multiple programs through partnership, including an IRAK4 degrader in Phase 1 in partnership with Gilead and a STAT6 degrader in IND enabling studies with Sanofi. Multiple additional wholly owned and partnered programs are at various stages of preclinical development. Position: Reporting to the Director, Regulatory Affairs Project Management and Operations, the Senior Manager, Regulatory Operations provides key support to the Nurix Regulatory Affairs department. This position has responsibility for entry-level coordination, review, assembly and archival of regulatory submissions in Veeva RIMS and documents for health authorities (US FDA and global equivalents). The Senior Manager, Regulatory Operations will provide support for

  • Associate Director, Quantitative Pharmacology and Pharmacometrics

    Brisbane, CA

    unspecified Salary not disclosed

    Associate Director, Quantitative Pharmacology and Pharmacometrics Brisbane, CA Associate Director, Quantitative Pharmacology and Pharmacometrics Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Position The Associate Director in the Clinical Pharmacology group will contribute to pharmacometric efforts across early and late-stage programs. As an early member of the Clinical Pharmacology group, you will have an opportunity to influence the direction of the clinical pharmacology group at Nurix. The successful applicant shall be proficient in developing and executing PK/PD modeling and simulation activities, such as but not limited to population PK/PD modeling, physiologically-based PK (PBPK) modeling and quantitative systems pharmacology (QSP) modeling. This includes data analysis and interpretation and presentation of findings to optimize doses, dosage regimens and study designs. The candidate will also