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Keros Therapeutics Inc

7 open roles indexed with location, benefit, and apply-link signals where available.

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  • Contract Process Development Associate II

    Lexington, Massachusetts, United States

    unspecified Salary not disclosed

    Contract Process Development Associate II Lexington, Massachusetts, United States At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. This role is responsible for providing overall support in early stages of process development and acting as an interface with the Research and CMC organizations. This person will be responsible for executing and developing stage appropriate downstream processes for novel protein therapeutics. Developing downstream purification processes for expression scales that range from shake flasks to pilot scale bioreactors. Theis person will also be involved in providing and analyzing data and relevant information for reports supporting tech transfer activities for external manufacturing. Responsibilities: - Hands-on execution, and optimization of protein purification processes including primary recovery unit operations (centrifugation, homogenization, flocculation, tangential-flow filtration (TFF), and depth filtration), chromatography (ion-exchange, affinity, hydrophobic interaction), and pre-formulation (TFF, dialysis) - Generate and analyze process and analytical data supporting key documents such as development reports, regulatory submissions, and technology transfer packages - Execute routine scale

  • Senior Research Associate I, Bioanalytical

    Lexington, Massachusetts, United States

    unspecified $74K-$99K

    Senior Research Associate I, Bioanalytical Lexington, Massachusetts, United States At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Job Summary: Keros is seeking a Senior Research Associate with working knowledge of large molecule/ biologics bioanalytical techniques and laboratory skills. This person will develop and perform bioanalytical methods for programs in preclinical and clinical development, document the methods used, interpret, and summarize the data collected. This role will report into the Bioanalytical Scientist and will be responsible for activities related to the development, qualification and bio-analysis for non-regulated methods and samples in support of drug candidate development. This individual will have the opportunity to directly contribute to the bioanalytical assay development for platform and therapeutic areas, and work in a fast-paced environment as part of a highly collaborative team. This is a full-time laboratory position based in Lexington, MA. Primary Responsibilities: - Design, develop, optimize, and execute bioanalytical assays to support nonclinical studies, including PK, PD, biomarker, and

  • Director, Regulatory Operations

    Lexington, MA (Hybrid)

    hybrid $206K-$227K

    Director, Regulatory Operations Lexington, MA (Hybrid) At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Job Summary: Reporting to the Head Regulatory Affairs, the Director of Regulatory Operations will be responsible for establishing the Regulatory Operations role at Keros. This individual will leverage their extensive knowledge of Regulatory Operations to support Keros' growing regulatory needs including inhouse publishing as well as working with multiple external vendors. Primary Responsibilities: - Oversee all Regulatory Operations deliverables, including management of Health Authority correspondence/submission archives, business administration of the Veeva Vault Regulatory Information Management system, submission management, and training of associated business processes - Implement training strategies, develop training materials, and lead training delivery for effective adoption of Vault RIM - Manage user groups and workflows and create and maintain archives of Health Authority interactions - Develop, manage, and distribute reports, dashboards, and templates to meet user needs - Contribute to the writing, review, and implementation of standards and procedures related

  • Contract Research Associate II, Protein Science

    Lexington, Massachusetts, United States

    unspecified Salary not disclosed

    Contract Research Associate II, Protein Science Lexington, Massachusetts, United States At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Keros Therapeutics is seeking a highly motivated and collaborative individual to join our protein biochemistry group within our Research Department. Our group exploits multidisciplinary approaches in protein sciences and protein engineering, to better the understanding of the biochemical, biophysical, and structural functional properties of the biomolecules within the TGF-β superfamily that drive the signaling pathway. Our efforts greatly contribute to advance innovative research and drug discovery and heavily support our discovery pipeline. You will have the opportunity to learn about and contribute to early-stage drug discovery from a protein chemistry perspective as well as through internal and external collaboration with other departments. You will play an important role supporting in vivo and in vitro studies crucial for the progress of our therapeutic research programs by generating high-quality proteins and other reagents in this hands-on laboratory position. The successful

  • Medical Director

    Lexington, MA (Hybrid)

    hybrid $248K-$310K

    Medical Director Lexington, MA (Hybrid) At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Job Summary: Keros is searching for a Medical Director to drive clinical development of assets in its pipeline. The ideal candidate will be a physician or medical provider with therapeutic area expertise, medical monitoring experience, and a general understanding of clinical drug development within the biopharmaceutical industry. The role requires medical and scientific oversight along with hands-on participation in all aspects of clinical trial execution, ensuring the safety of trial participants and the scientific integrity of the data collected. The Medical Director will also lead and participate in teleconferences with study Investigators, advisory meetings with key opinion leaders (KOLs), and interactions with Health Authorities, as indicated. A genuine interest in learning and understanding the science supporting the pipeline, an ability to work collaboratively in a highly matrixed multidisciplinary team setting, and a commitment to developing new treatments for patients in need are critical

  • Research Associate Co-Op, In Vitro Pharmacology

    Lexington, Massachusetts, United States

    unspecified Salary not disclosed

    Research Associate Co-Op, In Vitro Pharmacology Lexington, Massachusetts, United States At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Job Summary We are seeking a highly motivated Biology/Biochemistry Major Co-op to join our In Vitro Pharmacology team for a 6-month Research Associate position. As a co-op student, you will have the opportunity to collaborate with our experienced scientists and researchers, gaining valuable insights into the field of cell/molecular biology, and contributing to our ongoing drug discovery projects. Primary Responsibilities - Maintain and culture multiple cell lines - Participate in protocol development and optimization of cellular assays - Conduct reporter assays to assess cellular signaling events - Regularly perform gene expression, protein detection analysis - Maintain accurate and detailed laboratory records - Collaborate with team members on research projects Core Competencies (Required Skills) - Previous training in cell/molecular biology laboratory skills and familiarity with cell culture techniques Preferred Skills - Excellent attention to detail and organizational skills -

  • Join our Talent Community

    Lexington, Massachusetts, United States

    unspecified Salary not disclosed

    Join our Talent Community Lexington, Massachusetts, United States At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients. Don't see a job posting that fits your background? That's OK. Please apply below to be considered for future opportunities. Our Diversity, Equity & Inclusion Mission Statement: Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members. Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law. Recruitment & Staffing Agencies: Keros Therapeutics does not accept unsolicited resumes from any source other than the candidate directly. Any