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PhD with 0-2 years of experience in academic or industry setting, MS with 6+ years of experience or BS with 8+ years of experience - Broad knowledge of genome editing technologies and associated off-target discovery assays - Genomic assay development or deployment experience for off-target discovery, verification and structural variation assessment - Familiarity with NGS workflows and library preparation - Deploying PCR-based off-target verification assays such as rhAmpSeq and Hybrid Capture Sequencing - Developing and deploying unidirectional/ligation-mediated PCR assays - Assay related molecular biology techniques including DNA extraction, nucleic acid quality assessment and primer design - Basic cell biology skills including cell line culture and manipulation techniques (electroporation and transfection) - Strong written and verbal communication skills You are interested in… - Developing and deploying assays for genomic safety assessment for the development of Gene Writer candidates - Developing, deploying and analyzing NGS-based assays for off-target discovery and verification - Examining genome structural variants using optical and molecular methods - Working collaboratively with genomic safety, molecular assay, computational biology and regulatory sciences teams to advance Tessera's therapeutic programs - Contributing to scientific report writing, translating complex experimental findings to support regulatory and research goals About you: You are a rigorous, detail-oriented scientist with expertise in genome editing and genomic safety assessment. 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Director, Head of Program Management at Tessera Therapeutics - Somerville, Massachusetts, United States - Director, Head of Program Management Somerville, Massachusetts, United States Your experience includes… - Bachelor's in life sciences, engineering, business, or a related field with 15 years related experience or Masters with 13 years related experience or PhD with 10 years of related experience - Significant experience in program management, program operations, or cross-functional development teams in a dynamic biotech or pharmaceutical environment - Strong understanding of drug development from research through preclinical development, IND-enabling activities, regulatory submissions, and clinical development. It's a bonus if you have commercial experience. - Demonstrated ability to bridge science and business interests - Excellent written and verbal communication skills - Being well-versed in program management principles, practices, and tools (including Office Timeline, Think-Cell, and Smartsheet/Microsoft Project) - Thriving in a dynamic and rigorous work environment, coaching and mentoring - It's a bonus if you have your Project Management Professional (PMP®) certification or experience in genetic medicines You are interested in… - Building and leading a fit-for-purpose Program Management function that enables strong execution, transparent communication, and effective decision-making across the organization - Guiding and empowering Program Managers to drive the development and management of integrated program plans (including timelines, assumptions, scenarios, risks, critical path, decision maps, goals, and budget drivers) - Establishing and continuously improving program management capabilities, tools, and practices - Partnering with Finance and Corporate Development to prepare for Portfolio Reviews - Facilitating and contributing to the Programs/Portfolio goal setting & tracking, in line with enterprise goals - Systematically monitoring program risks and

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Senior Research Associate, Novel Delivery Technologies (Contract) at Tessera Therapeutics - Somerville, Massachusetts, United States - Senior Research Associate, Novel Delivery Technologies (Contract) Somerville, Massachusetts, United States Sr. Research Associate, Novel Delivery Technologies Your experience includes… - A Bachelor's degree in Chemistry, Chemical Engineering, Bioengineering, or related discipline and 2-4 years of experience, or a Master's degree in these fields with 1-2 years of experience. - Prior experience with either of the following: - Working with lipid nanoparticles (LNPs), including their manufacture and characterization. - Implementing various bioconjugation techniques. - A track record of planning experiments and completing deliverables within specified timelines. - Excellent communication/presentation skills and capability of conveying technical information in a clear and thorough manner. - A strong self-starter with excellent organizational skills and a strong attention to detail. - The ability to work with dynamic teams in a fast-paced, entrepreneurial, and technical setting. - Industrial research experience is preferred. - It's a bonus if you have: - Knowledge of nucleic acid chemistry and biology - Prior experience with various protein characterization techniques - Experience with lipid nanoparticle process scale up/down - Process development and/or analytical development experience You are interested in… - Assisting in the development of an extrahepatic LNP delivery vehicle to support delivery of editing payloads in vivo. - Assisting with experimental design and execution of formulation discovery and platform development activities. - Performing characterization of LNPs to determine size, polydispersity, concentration and encapsulation using established techniques. - Performing characterization of LNPs to determine RNA and protein content. - Executing experimental plans and interpreting the results with guidance from senior

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Senior Research Associate, Foundry (Contract) at Tessera Therapeutics - Somerville, Massachusetts, United States - Senior Research Associate, Foundry (Contract) Somerville, Massachusetts, United States Your experience includes… - BS in Biology, Chemistry, Biochemistry, Biotechnology or related field with 4+ years of industry experience; or MS in these fields with 2+ years of industry experience - Strong foundation in molecular biology techniques and cloning workflows - Expertise in different cloning methodologies such as Gibson, Golden-Gate, and Site-Directed Mutagenesis (SDM) - Execution of end-to-end plasmid workflows including design, assembly, transformation, screening, and sequence verification - Performing plasmid QC (DNA quantification, Sanger sequencing, and residual protein) and maintaining inventory for downstream applications - Proficiency with software tools such as Benchling, Geneious, or similar - Accurate record keeping of experimental data and maintenance of detailed electronic notebooks - Adhere to laboratory safety guidelines, SOPs, and regulatory requirements - Excellent organizational skills, attention to detail, and ability to manage multiple priorities in a fast-paced environment - Ability to work independently as well as part of a collaborative team - Experience with automated liquid handlers and high-throughput workflows is preferred You are interested in… - Contribute to the optimization and continuous improvement of DNA production workflows and processes - Perform DNA assembly, analyze and interpret experimental data, and ensure accurate reporting and documentation - Collaborate with the automation team to develop, optimize, and implement laboratory protocols - Work cross-functionally with R&D, analytical, and bioinformatics teams to support project objectives and timelines - Participate in team meetings and contribute to the planning and execution of new initiatives and projects - Stay current

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Scientist I, Genotox (Contract) at Tessera Therapeutics - Somerville, Massachusetts, United States - Scientist I, Genotox (Contract) Somerville, Massachusetts, United States Your experience includes… - PhD with 0-2 years of experience in academic or industry setting, MS with 6+ years of experience or BS with 8+ years of experience - Broad knowledge of genome editing technologies and associated off-target discovery assays - Genomic assay development or deployment experience for off-target discovery, verification and structural variation assessment - Familiarity with NGS workflows and library preparation - Deploying PCR-based off-target verification assays such as rhAmpSeq and Hybrid Capture Sequencing - Developing and deploying unidirectional/ligation-mediated PCR assays - Assay related molecular biology techniques including DNA extraction, nucleic acid quality assessment and primer design - Basic cell biology skills including cell line culture and manipulation techniques (electroporation and transfection) - Strong written and verbal communication skills You are interested in… - Developing and deploying assays for genomic safety assessment for the development of Gene Writer candidates - Developing, deploying and analyzing NGS-based assays for off-target discovery and verification - Examining genome structural variants using optical and molecular methods - Working collaboratively with genomic safety, molecular assay, computational biology and regulatory sciences teams to advance Tessera's therapeutic programs - Contributing to scientific report writing, translating complex experimental findings to support regulatory and research goals About you: You are a rigorous, detail-oriented scientist with expertise in genome editing and genomic safety assessment. As a Scientist I on our Genomic Safety team, you will design, develop, and deploy cutting-edge assays to characterize the off-target landscape of our Gene Writer therapeutics

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