{ "slug": "general-proximity", "canonical_name": "General Proximity", "website": "https://generalproximity.bio", "ats": "greenhouse", "top_startup": true, "top_startup_sources": [ "yc" ], "total_active_jobs": 10, "verified_benefits": { "parental_leave_weeks": null, "non_birth_parent_leave_weeks": null, "source_url": null, "verified_count": 0, "last_verified": null }, "awards": null, "jobs": [ { "id": "ddade77d6d1ddc85c35f7bd072540344", "title": "Scientist, Medicinal Chemistry", "employer_name": "General Proximity", "employer_slug": "general-proximity", "location_text": "San Francisco, CA", "country": "US", "employment_type": "unknown", "remote_status": "unspecified", "remote_status_source": null, "remote_status_enriched_at": null, "days_in_office": null, "timezone_overlap_hours": 6, "salary_min": null, "salary_max": null, "salary_min_source": null, "salary_max_source": null, "salary_currency": "UNSPECIFIED", "salary_type": "base", "salary_type_source": null, "salary_type_enriched_at": null, "salary_period": null, "base_salary_min": null, "base_salary_max": null, "salary_disclosed": false, "equity_included": true, "equity_included_source": null, "equity_type": [ "options" ], "k401_match": null, "match_401k_pct": null, "match_401k_pct_source": null, "k401_match_source_url": null, "k401_match_source_fields": [], "k401_contribution_source_url": null, "k401_contribution_source_fields": [], "profit_sharing": false, "bonus_offered": false, "mental_health_support": null, "childcare_subsidy": null, "fertility_family_building_benefits": null, "adoption_assistance_offered": null, "surrogacy_assistance_offered": null, "learning_budget_offered": null, "relocation_assistance": null, "top_startup_sources": [ "yc" ], "posted_at": "2026-05-29T22:15:44.000Z", "apply_url": "https://job-boards.greenhouse.io/generalproximity/jobs/6009487004", "apply_url_verified": false, "ats": "greenhouse", "url_last_checked_alive": null, "removed_at": null, "description_excerpt": "Scientist, Medicinal Chemistry San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking a medicinal chemist to be a member of our Chemistry/Drug Discovery Team. 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Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate mechanistic biologist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced mechanistic biologist to join our Discovery Biology Team. 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Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate computational chemist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced Head of Computational Chemistry to build and lead our computational chemistry, cheminformatics, and molecular design capabilities. This role will drive small-molecule drug discovery programs by providing strategic and practical modeling support, implementing modern", "parental_leave_weeks": null, "non_birth_parent_leave_weeks": null, "parental_leave_weeks_source": null, "non_birth_parent_leave_weeks_source": null, "parental_leave_source_url": null, "pto_days": null, "unlimited_pto": false, "sabbatical_eligible": false, "family_friendly_score": 43, "benefit_verified": false, "benefit_last_verified": null, "hire_states_allowed": [], "state_eligibility_source": null, "state_eligibility_enriched_at": null, "llm_quality_pass_at": null, "seniority": "staff_plus", "years_experience_min": 15, "years_experience_max": null, "role_function": "other", "employer_industry": null, "employer_size": "51-200", "quality_score": 45, "travel_pct": null, "requires_shift": null, "shift_type": "unknown", "shift_type_source": null, "weekend_work": "unknown", "weekend_work_source": null, "relocation_assistance_source": null, "contractor_w2": "unknown", "required_timezone": null, "fertility_family_building_benefits_source": null, "mental_health_support_source": null, "adoption_assistance_offered_source": null, "childcare_subsidy_source": null, "learning_budget_offered_source": null, "surrogacy_assistance_offered_source": null, "cover_letter_required": null, "cover_letter_required_source": null, "assessment_required": null, "assessment_required_source": null, "application_deadline": null, "application_deadline_source": null, "visa_sponsorship": false, "us_citizenship_required": false, "security_clearance": "none", "education_required": "doctorate", "roll_up_count": null, "roll_up_total_locations": null, "explanations": [] }, { "id": "e289573cfb3f753cef610818b9503f63", "title": "Head of DMPK", "employer_name": "General Proximity", "employer_slug": "general-proximity", "location_text": "San Francisco, CA", "country": "US", "employment_type": "contract", "remote_status": "unspecified", "remote_status_source": null, "remote_status_enriched_at": null, "days_in_office": null, "timezone_overlap_hours": 6, "salary_min": null, "salary_max": null, "salary_min_source": null, "salary_max_source": null, "salary_currency": "UNSPECIFIED", "salary_type": "unknown", "salary_type_source": null, "salary_type_enriched_at": null, "salary_period": null, "base_salary_min": null, "base_salary_max": null, "salary_disclosed": false, "equity_included": true, "equity_included_source": null, "equity_type": [ "options" ], "k401_match": null, "match_401k_pct": null, "match_401k_pct_source": null, "k401_match_source_url": null, "k401_match_source_fields": [], "k401_contribution_source_url": null, "k401_contribution_source_fields": [], "profit_sharing": false, "bonus_offered": false, "mental_health_support": null, "childcare_subsidy": null, "fertility_family_building_benefits": null, "adoption_assistance_offered": null, "surrogacy_assistance_offered": null, "learning_budget_offered": null, "relocation_assistance": null, "top_startup_sources": [ "yc" ], "posted_at": "2026-05-15T21:26:27.000Z", "apply_url": "https://job-boards.greenhouse.io/generalproximity/jobs/5997363004", "apply_url_verified": false, "ats": "greenhouse", "url_last_checked_alive": null, "removed_at": null, "description_excerpt": "Head of DMPK San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate DMPK expert to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced Head of DMPK to lead and shape our drug metabolism and pharmacokinetics function. This is a high-impact leadership role in which you will own the DMPK strategy across our small molecule portfolio, build and", "parental_leave_weeks": null, "non_birth_parent_leave_weeks": null, "parental_leave_weeks_source": null, "non_birth_parent_leave_weeks_source": null, "parental_leave_source_url": null, "pto_days": null, "unlimited_pto": false, "sabbatical_eligible": false, "family_friendly_score": 43, "benefit_verified": false, "benefit_last_verified": null, "hire_states_allowed": [], "state_eligibility_source": null, "state_eligibility_enriched_at": null, "llm_quality_pass_at": null, "seniority": "staff_plus", "years_experience_min": 8, "years_experience_max": 12, "role_function": "other", "employer_industry": null, "employer_size": "51-200", "quality_score": 45, "travel_pct": null, "requires_shift": null, "shift_type": "unknown", "shift_type_source": null, "weekend_work": "unknown", "weekend_work_source": null, "relocation_assistance_source": null, "contractor_w2": "unknown", "required_timezone": null, "fertility_family_building_benefits_source": null, "mental_health_support_source": null, "adoption_assistance_offered_source": null, "childcare_subsidy_source": null, "learning_budget_offered_source": null, "surrogacy_assistance_offered_source": null, "cover_letter_required": null, "cover_letter_required_source": null, "assessment_required": null, "assessment_required_source": null, "application_deadline": null, "application_deadline_source": null, "visa_sponsorship": false, "us_citizenship_required": false, "security_clearance": "none", "education_required": "doctorate", "roll_up_count": null, "roll_up_total_locations": null, "explanations": [] }, { "id": "257aba88f06bb6fe14dd2d6987f01a75", "title": "Scientist II/Senior Scientist, Medicinal Chemistry", "employer_name": "General Proximity", "employer_slug": "general-proximity", "location_text": "San Francisco, CA", "country": "US", "employment_type": "unknown", "remote_status": "unspecified", "remote_status_source": null, "remote_status_enriched_at": null, "days_in_office": null, "timezone_overlap_hours": 6, "salary_min": null, "salary_max": null, "salary_min_source": null, "salary_max_source": null, "salary_currency": "UNSPECIFIED", "salary_type": "unknown", "salary_type_source": null, "salary_type_enriched_at": null, "salary_period": null, "base_salary_min": null, "base_salary_max": null, "salary_disclosed": false, "equity_included": true, "equity_included_source": null, "equity_type": [ "options" ], "k401_match": null, "match_401k_pct": null, "match_401k_pct_source": null, "k401_match_source_url": null, "k401_match_source_fields": [], "k401_contribution_source_url": null, "k401_contribution_source_fields": [], "profit_sharing": false, "bonus_offered": false, "mental_health_support": null, "childcare_subsidy": null, "fertility_family_building_benefits": null, "adoption_assistance_offered": null, "surrogacy_assistance_offered": null, "learning_budget_offered": null, "relocation_assistance": null, "top_startup_sources": [ "yc" ], "posted_at": "2026-04-23T22:08:17.000Z", "apply_url": "https://job-boards.greenhouse.io/generalproximity/jobs/5980552004", "apply_url_verified": false, "ats": "greenhouse", "url_last_checked_alive": null, "removed_at": null, "description_excerpt": "Scientist II/Senior Scientist, Medicinal Chemistry San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an exceptional medicinal chemist to join our Chemistry and Drug Discovery team. This is a rare opportunity to help build a next-generation drug discovery company from the ground up and contribute directly to the", "parental_leave_weeks": null, "non_birth_parent_leave_weeks": null, "parental_leave_weeks_source": null, "non_birth_parent_leave_weeks_source": null, "parental_leave_source_url": null, "pto_days": null, "unlimited_pto": false, "sabbatical_eligible": false, "family_friendly_score": 43, "benefit_verified": false, "benefit_last_verified": null, "hire_states_allowed": [], "state_eligibility_source": null, "state_eligibility_enriched_at": null, "llm_quality_pass_at": null, "seniority": "senior", "years_experience_min": 5, "years_experience_max": 9, "role_function": "data", "employer_industry": null, "employer_size": "51-200", "quality_score": 45, "travel_pct": null, "requires_shift": null, "shift_type": "unknown", "shift_type_source": null, "weekend_work": "unknown", "weekend_work_source": null, "relocation_assistance_source": null, "contractor_w2": "unknown", "required_timezone": null, "fertility_family_building_benefits_source": null, "mental_health_support_source": null, "adoption_assistance_offered_source": null, "childcare_subsidy_source": null, "learning_budget_offered_source": null, "surrogacy_assistance_offered_source": null, "cover_letter_required": null, "cover_letter_required_source": null, "assessment_required": null, "assessment_required_source": null, "application_deadline": null, "application_deadline_source": null, "visa_sponsorship": false, "us_citizenship_required": false, "security_clearance": "none", "education_required": "doctorate", "roll_up_count": null, "roll_up_total_locations": null, "explanations": [] }, { "id": "3394590dc365f178038d0d891124bfa4", "title": "Lab Technician/Operations Manager", "employer_name": "General Proximity", "employer_slug": "general-proximity", "location_text": "San Francisco, CA", "country": "US", "employment_type": "unknown", "remote_status": "unspecified", "remote_status_source": null, "remote_status_enriched_at": null, "days_in_office": null, "timezone_overlap_hours": 6, "salary_min": null, "salary_max": null, "salary_min_source": null, "salary_max_source": null, "salary_currency": "UNSPECIFIED", "salary_type": "base", "salary_type_source": null, "salary_type_enriched_at": null, "salary_period": null, "base_salary_min": null, "base_salary_max": null, "salary_disclosed": false, "equity_included": true, "equity_included_source": null, "equity_type": [ "options" ], "k401_match": null, "match_401k_pct": null, "match_401k_pct_source": null, "k401_match_source_url": null, "k401_match_source_fields": [], "k401_contribution_source_url": null, "k401_contribution_source_fields": [], "profit_sharing": false, "bonus_offered": true, "mental_health_support": null, "childcare_subsidy": null, "fertility_family_building_benefits": null, "adoption_assistance_offered": null, "surrogacy_assistance_offered": null, "learning_budget_offered": null, "relocation_assistance": null, "top_startup_sources": [ "yc" ], "posted_at": "2026-02-18T23:18:34.000Z", "apply_url": "https://job-boards.greenhouse.io/generalproximity/jobs/5807853004", "apply_url_verified": false, "ats": "greenhouse", "url_last_checked_alive": null, "removed_at": null, "description_excerpt": "Lab Technician/Operations Manager San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate Lab Technician / Operations Manager to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced Laboratory Technician / Operations Manager to support our Biology and Platform teams. In this position, you will work at the intersection of lab operations, infrastructure management, and research and development. 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Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate research associate to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. 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Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate chemical biologist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. 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Send us your resume/CV by applying here, and we will add you to our talent pool and reach out once we find a good fit! tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking first-rate scientists to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. 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Initiative,", "parental_leave_weeks": null, "non_birth_parent_leave_weeks": null, "parental_leave_weeks_source": null, "non_birth_parent_leave_weeks_source": null, "parental_leave_source_url": null, "pto_days": null, "unlimited_pto": false, "sabbatical_eligible": false, "family_friendly_score": 43, "benefit_verified": false, "benefit_last_verified": null, "hire_states_allowed": [], "state_eligibility_source": null, "state_eligibility_enriched_at": null, "llm_quality_pass_at": null, "seniority": "mid", "years_experience_min": 3, "years_experience_max": 7, "role_function": "other", "employer_industry": null, "employer_size": "51-200", "quality_score": 45, "travel_pct": null, "requires_shift": null, "shift_type": "unknown", "shift_type_source": null, "weekend_work": "unknown", "weekend_work_source": null, "relocation_assistance_source": null, "contractor_w2": "unknown", "required_timezone": null, "fertility_family_building_benefits_source": null, "mental_health_support_source": null, "adoption_assistance_offered_source": null, "childcare_subsidy_source": null, "learning_budget_offered_source": null, "surrogacy_assistance_offered_source": null, "cover_letter_required": null, "cover_letter_required_source": null, "assessment_required": null, "assessment_required_source": null, "application_deadline": null, "application_deadline_source": null, "visa_sponsorship": false, "us_citizenship_required": false, "security_clearance": "none", "education_required": "none", "roll_up_count": null, "roll_up_total_locations": null, "explanations": [] }, { "id": "ef69498ea995c651221fc4edabf77581", "title": "Principal Scientist, Cancer Biology", "employer_name": "General Proximity", "employer_slug": "general-proximity", "location_text": "San Francisco, CA", "country": "US", "employment_type": "unknown", "remote_status": "unspecified", "remote_status_source": null, "remote_status_enriched_at": null, "days_in_office": null, "timezone_overlap_hours": 6, "salary_min": null, "salary_max": null, "salary_min_source": null, "salary_max_source": null, "salary_currency": "UNSPECIFIED", "salary_type": "base", "salary_type_source": null, "salary_type_enriched_at": null, "salary_period": null, "base_salary_min": null, "base_salary_max": null, "salary_disclosed": false, "equity_included": true, "equity_included_source": null, "equity_type": [ "options" ], "k401_match": null, "match_401k_pct": null, "match_401k_pct_source": null, "k401_match_source_url": null, "k401_match_source_fields": [], "k401_contribution_source_url": null, "k401_contribution_source_fields": [], "profit_sharing": false, "bonus_offered": false, "mental_health_support": null, "childcare_subsidy": null, "fertility_family_building_benefits": null, "adoption_assistance_offered": null, "surrogacy_assistance_offered": null, "learning_budget_offered": null, "relocation_assistance": null, "top_startup_sources": [ "yc" ], "posted_at": "2024-06-07T22:34:19.000Z", "apply_url": "https://job-boards.greenhouse.io/generalproximity/jobs/5199733004", "apply_url_verified": false, "ats": "greenhouse", "url_last_checked_alive": null, "removed_at": null, "description_excerpt": "Principal Scientist, Cancer Biology San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate cancer biologist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \"undruggable\" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. 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Scientist, Medicinal Chemistry at General Proximity - San Francisco, CA - Scientist, Medicinal Chemistry San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking a medicinal chemist to be a member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the

", "datePosted": "2026-05-29T22:15:44.000Z", "employmentType": "OTHER", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "ddade77d6d1ddc85c35f7bd072540344" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options)", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 36 }, "educationRequirements": "Doctorate", "url": "https://fewerjobs.com/jobs/general-proximity/scientist-medicinal-chemistry-ddade77d" } }, { "@type": "ListItem", "position": 2, "url": "https://fewerjobs.com/jobs/general-proximity/scientist-mechanistic-biology-feda7576", "item": { "@context": "https://schema.org", "@type": "JobPosting", "title": "Scientist, Mechanistic Biology", "description": "

Scientist, Mechanistic Biology at General Proximity - San Francisco, CA - Scientist, Mechanistic Biology San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate mechanistic biologist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced mechanistic biologist to join our Discovery Biology Team. In this position, you will work closely with our Platform and Chemistry Teams to drive mechanistic understanding of our lead compounds and support core drug discovery

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Head of Computational Chemistry at General Proximity - San Francisco, CA - Head of Computational Chemistry San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate computational chemist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced Head of Computational Chemistry to build and lead our computational chemistry, cheminformatics, and molecular design capabilities. This role will drive small-molecule drug discovery programs by providing strategic and practical modeling support, implementing modern

", "datePosted": "2026-05-15T22:06:30.000Z", "employmentType": "OTHER", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "b2ffa920cc6c6fbff1ce5371c11bb9e9" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options)", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 180 }, "educationRequirements": "Doctorate", "url": "https://fewerjobs.com/jobs/general-proximity/head-of-computational-chemistry-b2ffa920" } }, { "@type": "ListItem", "position": 4, "url": "https://fewerjobs.com/jobs/general-proximity/head-of-dmpk-e289573c", "item": { "@context": "https://schema.org", "@type": "JobPosting", "title": "Head of DMPK", "description": "

Head of DMPK at General Proximity - San Francisco, CA - Head of DMPK San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate DMPK expert to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced Head of DMPK to lead and shape our drug metabolism and pharmacokinetics function. This is a high-impact leadership role in which you will own the DMPK strategy across our small molecule portfolio, build and

", "datePosted": "2026-05-15T21:26:27.000Z", "employmentType": "CONTRACTOR", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "e289573cfb3f753cef610818b9503f63" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options)", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 96 }, "educationRequirements": "Doctorate", "url": "https://fewerjobs.com/jobs/general-proximity/head-of-dmpk-e289573c" } }, { "@type": "ListItem", "position": 5, "url": "https://fewerjobs.com/jobs/general-proximity/scientist-ii-senior-scientist-medicinal-chemistry-257aba88", "item": { "@context": "https://schema.org", "@type": "JobPosting", "title": "Scientist II/Senior Scientist, Medicinal Chemistry", "description": "

Scientist II/Senior Scientist, Medicinal Chemistry at General Proximity - San Francisco, CA - Scientist II/Senior Scientist, Medicinal Chemistry San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an exceptional medicinal chemist to join our Chemistry and Drug Discovery team. This is a rare opportunity to help build a next-generation drug discovery company from the ground up and contribute directly to the

", "datePosted": "2026-04-23T22:08:17.000Z", "employmentType": "OTHER", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "257aba88f06bb6fe14dd2d6987f01a75" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options)", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 60 }, "educationRequirements": "Doctorate", "url": "https://fewerjobs.com/jobs/general-proximity/scientist-ii-senior-scientist-medicinal-chemistry-257aba88" } }, { "@type": "ListItem", "position": 6, "url": "https://fewerjobs.com/jobs/general-proximity/lab-technician-operations-manager-3394590d", "item": { "@context": "https://schema.org", "@type": "JobPosting", "title": "Lab Technician/Operations Manager", "description": "

Lab Technician/Operations Manager at General Proximity - San Francisco, CA - Lab Technician/Operations Manager San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate Lab Technician / Operations Manager to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced Laboratory Technician / Operations Manager to support our Biology and Platform teams. In this position, you will work at the intersection of lab operations, infrastructure management, and research and development. This

", "datePosted": "2026-02-18T23:18:34.000Z", "employmentType": "OTHER", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "3394590dc365f178038d0d891124bfa4" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options); Bonus", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 24 }, "educationRequirements": "no requirements", "url": "https://fewerjobs.com/jobs/general-proximity/lab-technician-operations-manager-3394590d" } }, { "@type": "ListItem", "position": 7, "url": "https://fewerjobs.com/jobs/general-proximity/research-associate-drug-discovery-d5c0ce0e", "item": { "@context": "https://schema.org", "@type": "JobPosting", "title": "Research Associate, Drug Discovery", "description": "

Research Associate, Drug Discovery at General Proximity - San Francisco, CA - Research Associate, Drug Discovery San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate research associate to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced Research Associate to be a key member of our Platform/Drug Discovery Team. In this position, you will work in close conjunction with our Biology Team in the development of our core drug discovery

", "datePosted": "2025-09-26T21:42:08.000Z", "employmentType": "OTHER", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "d5c0ce0e3cc18b6d80a6587451c41a68" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options)", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 36 }, "educationRequirements": "no requirements", "url": "https://fewerjobs.com/jobs/general-proximity/research-associate-drug-discovery-d5c0ce0e" } }, { "@type": "ListItem", "position": 8, "url": "https://fewerjobs.com/jobs/general-proximity/scientist-sr-scientist-chemical-biology-fe511f04", "item": { "@context": "https://schema.org", "@type": "JobPosting", "title": "Scientist/Sr. Scientist, Chemical Biology", "description": "

Scientist/Sr. Scientist, Chemical Biology at General Proximity - San Francisco, CA - Scientist/Sr. Scientist, Chemical Biology San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate chemical biologist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced chemical biologist with medicinal chemistry training to be a founding member of our Chemistry/Drug Discovery Team . In this position, you will work with both our Chemistry and Platform Teams in the development

", "datePosted": "2025-09-26T19:27:14.000Z", "employmentType": "OTHER", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "fe511f04ab437ef72f9d4ac848bb5b76" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options)", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 60 }, "educationRequirements": "Doctorate", "url": "https://fewerjobs.com/jobs/general-proximity/scientist-sr-scientist-chemical-biology-fe511f04" } }, { "@type": "ListItem", "position": 9, "url": "https://fewerjobs.com/jobs/general-proximity/other-positions-20439f0c", "item": { "@context": "https://schema.org", "@type": "JobPosting", "title": "Other Positions", "description": "

Other Positions at General Proximity - San Francisco, CA - Other Positions San Francisco, CA Other Position(s) Interested in working with us but don't see a position that fits? Send us your resume/CV by applying here, and we will add you to our talent pool and reach out once we find a good fit! tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking first-rate scientists to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. About You High Agency. Initiative,

", "datePosted": "2024-09-17T20:52:45.000Z", "employmentType": "OTHER", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "20439f0ce5d1b708ebdbaf46654cf305" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options)", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 36 }, "educationRequirements": "no requirements", "url": "https://fewerjobs.com/jobs/general-proximity/other-positions-20439f0c" } }, { "@type": "ListItem", "position": 10, "url": "https://fewerjobs.com/jobs/general-proximity/principal-scientist-cancer-biology-ef69498e", "item": { "@context": "https://schema.org", "@type": "JobPosting", "title": "Principal Scientist, Cancer Biology", "description": "

Principal Scientist, Cancer Biology at General Proximity - San Francisco, CA - Principal Scientist, Cancer Biology San Francisco, CA tl;dr General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate cancer biologist to help us pioneer this uncharted frontier of drug discovery. Our Story A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition [1] , but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[ 2 , 3 , 4 ], and our technology holds the same promise. The Position We are seeking an experienced cancer biologist to help lead our Biology Team. In this position, you will help lead and manage our Biology Team and work closely with our Platform Team in the development of our core

", "datePosted": "2024-06-07T22:34:19.000Z", "employmentType": "OTHER", "identifier": { "@type": "PropertyValue", "name": "General Proximity", "value": "ef69498ea995c651221fc4edabf77581" }, "hiringOrganization": { "@type": "Organization", "name": "General Proximity" }, "jobLocation": { "@type": "Place", "address": { "@type": "PostalAddress", "addressCountry": "US", "addressLocality": "San Francisco" } }, "directApply": false, "incentiveCompensation": "Equity (Options)", "experienceRequirements": { "@type": "OccupationalExperienceRequirements", "monthsOfExperience": 96 }, "educationRequirements": "Doctorate", "url": "https://fewerjobs.com/jobs/general-proximity/principal-scientist-cancer-biology-ef69498e" } } ] } ] }